Pattern of fall injuries in Pakistan: the Pakistan National Emergency Department Surveillance (Pak-NEDS) study.

Background: We aimed to analyse the frequency and patterns of fall-related injuries presenting to the emergency departments (EDs) across Pakistan.Methods: Pakistan National Emergency Departments surveillance system collected data from November 2010 to March 2011 on a 24/7 basis using a standardized tool in seven major EDs (five public and two private hospitals) in six major cities of Pakistan. For all patients presenting with fall-related injuries, we analysed data by intent with focus on unintentional falls. Simple frequencies were run for basic patient demographics, mechanism of falls, outcomes of fall injuries, mode of arrival to ED, investigations, and procedures with outcomes.Results: There were 3335 fall-related injuries. In cases where intent was available, two-thirds (n = 1186, 65.3%) of fall injuries were unintentional. Among unintentional fall patients presenting to EDs, the majority (76.9%) were males and between 15-44 years of age (69%). The majority of the unintentional falls (n = 671, 56.6%) were due to slipping, followed by fall from height (n = 338, 28.5%). About two-thirds (n = 675, 66.6%) of fall injuries involved extremities, followed by head/neck (n = 257, 25.4%) and face (n = 99, 9.8%). Most of the patients were discharged from the hospital (n = 1059, 89.3%). There were 17 (1.3%) deaths among unintentional fall cases.Conclusion: Falls are an important cause of injury-related visits to EDs in Pakistan. Most of the fall injury patients were men and in a productive age group. Fall injuries pose a burden on the healthcare system, especially emergency services, and future studies should therefore focus on safety measures at home and in workplaces to reduce this burden

Phytochemical screening and antibacterial activity of different fractions of Operculina turpethum root and leaf

ABSTRACT In Bangladesh, the herb Operculina turpethum is used for otitis media, suppurative sores, burns, conjunctivitis and skin diseases (eczema, abscesses, acne, scabies and warts) although the compounds responsible for the medicinal properties have not been identified. The present study has been undertaken for antibacterial activity of the ethanol, ether and chloroform extract of O. turpethum root and leaf. Antibacterial activity has been investigated against Shigella boydii, Shigella flese, Shigella dysenteriae, Escherichia coli, Proteus vulgaris, Salmonella typhi, Hafnia alvei, Staphylococcus epidermidis, Streptococcus pyogenes, Staphylococcus aureus, Enterococcus faecalis by disc diffusion and broth macro-dilution assay. The zone of inhibition has been observed with almost all bacteria with some exceptions. Minimum inhibitory concentrations (MIC) of the extracts were found to be significant

The Frequency Of Body Dysmorphic Disorder In Female University Students

Background: Body dysmorphic disorder (BDD), once known as dysmorphophobia, is a mental disorder in which the person afflicted is engrossed with an imagined imperfection in their appearance that is actually normal or is very minor. Methods: The cross-sectional study was conducted in Karachi at Ziauddin University targeting female students between the ages of 17– 25, using an adapted questionnaire which was used to diagnose BDD and determine the role of media in influencing their self-image. Results: Out of the 180 students included in this study, at least 9.4% were highly concerned about one or more than one physical attributes, while 2.8% showed extreme concern. 6.1% met the DSM-V criteria for BDD. The most frequent foci of concern were: Being too fat or too thin (35%), skin (24.4%), hair (15%), teeth (14%) and nose (14%). 24.4% of the students got sad/angry/depressed because of their appearance .The study also showed that 42% of the subjects spent 1-2 hours watching television every day, and 13.9% watching 3-7 hours of television per day. 46.7% also regularly visit entertainment/beauty websites or read entertainment magazines. 22.8% were extremely satisfied with their appearance, as opposed to 4.4% which were extremely dissatisfied. Conclusion: Our results show that BDD is widespread amongst female college students. The body features of concern were recognized and the influence that media, either through the use of beauty magazines or television/movies on self-image was estimated. Key Words: Body Dysmorphic disorder (BDD), Females, Frequency, Risk factor

Lawsonia Inermis Markedly Improves Cognitive Functions in Animal Models and Modulate Oxidative Stress Markers in the Brain

Background and Objective: Medicinal plants represent an important source of alternative medicine for the management of various diseases. The present study was undertaken to assess the potential of Lawsonia inermis ethanol (Li.Et) and chloroform (Li.Chf) extracts as memory-enhancing agents in experimental animals. Materials and Methods: Li.Et and Li.Chf were phytochemically characterized via gas chromatography-mass spectroscopy (GC-MS). Samples were tested for nootropic potentials at doses of 25, 50, 100, 200 mg/kg (per oral in experimental animals (p.o.)). Swiss albino mice of either sex (n = 210) were divided into 21 × 10 groups for each animal model. Memory-enhancing potentials of the samples were assessed using two methods including “without inducing amnesia” and “induction of amnesia” by administration of diazepam (1 mg/kg, intraperitoneally. Piracetam at 400 mg/kg (i.p.) was used as positive control. Cognitive behavioral models including elevated plus maze (EPM) and the passive shock avoidance (PSA) paradigm were used. Biochemical markers of oxidative stress such as glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) levels were analyzed in the brain tissue of treated mice. Results: In 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals scavenging assay, Li.Et and Li.Chf exhibited 70.98 ± 1.56 and 66.99 ± 1.76% inhibitions respectively at 1.28 mg/mL concentration. GCMS results revealed the presence of important phytochemicals. Both samples (Li.Et and Li.Chf) at 25 mg/kg (p.o.) dose significantly (p < 0.05) improved learning and memory as indicated by decline in transfer latency and increase in step down latency in EPM and PSA models respectively. Li.Et and Li.Chf at 25 mg/kg (p.o.) showed considerable increase in GSH (2.75 ± 0.018 ***), SOD (2.61 ± 0.059 ***) and CAT (2.71 ± 0.049 ***) levels as compared to positive and negative control groups. Conclusions: This study provides the preliminary clue that L. inermis may be a potential source of memory-enhancing and anti-oxidant compounds and thus warrant further studies

Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice

Inhibin is a molecule that belongs to peptide hormones and is excreted through pituitary gonadotropins stimulation action on the granulosa cells of the ovaries. However, the differential regulation of inhibin and follicle-stimulating hormone (FSH) on granulosa cell tumor growth in mice inhibin-deficient females is not yet well understood. The objective of this study was to evaluate the role of inhibin and FSH on the granulosa cells of ovarian follicles at the premature antral stage. This study stimulated immature wild-type (WT) and Inhibin-α knockout (Inha−/−) female mice with human chorionic gonadotropin (hCG) and examined hCG-induced gene expression changes in granulosa cells. Also, screening of differentially expressed genes (DEGs) was performed in the two groups under study. In addition, related modules to external traits and key gene drivers were determined through Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm. The results identified a number of 1074 and 931 DEGs and 343 overlapping DEGs (ODEGs) were shared in the two groups. Some 341 ODEGs had high relevance and consistent expression direction, with a significant correlation coefficient (r2 = 0.9145). Additionally, the gene co-expression network of selected 153 genes showed 122 nodes enriched to 21 GO biological processes (BP) and reproduction and 3 genes related to genomic pathways. By using principal component analysis (PCA), the 14 genes in the regulatory network were fixed and the cumulative proportion of fitted top three principal components was 94.64%. In conclusion, this study revealed the novelty of using ODEGs for investigating the inhibin and FSH hormone pathways that might open the way toward gene therapy for granulosa cell tumors. Also, these genes could be used as biomarkers for tracking the changes in inhibin and FSH hormone from the changes in the nutrition pattern

Internet of Things as Intimating for Pregnant Women’s Healthcare: An Impending Privacy Issues

Ingeniously, the innovations are taking place in current medical era, where IoT is a key and its related technology plays a dynamic role in pregnant women care taking inside hospital and outside. IoT ensure the effective and efficient care of pregnant women in any environment because intelligent tiny devices like RF-Tags, sensors are attached with pregnant women, and all the activities of pregnant women can be monitored by professional medical staff from anywhere and anytime. The usage of these advanced technologies in pregnant women care environment, absolutely eradicates the pregnancy complications and harmful incidents, but also raises privacy, religious, ethical, legal and social issues. The purpose of this paper is to discuss the usage of IoT in pregnant women healthcare environments and articulates endorsements to promote research then can guarantee that the pregnant women’s privacy is preserved. DOI : http://dx.doi.org/10.11591/telkomnika.v12i6.422

Toward Efficient Land Cover Mapping: An Overview of the National Land Representation System and Land Cover Map 2015 of Bangladesh

In response to prevailing classification inconsistency between land cover maps, developed by different organizations in different times at different scales, an object-based National Land Representation System (NLRS) for Bangladesh has been developed. The process, which began in 2013 and was completed in 2016, brought together several national organizations and involved an extensive process of consultation, data collection, translation, and analysis of existing land cover/use classification systems. The process focused on the interpretation of three legends from historic national land cover/use maps. Field inventory data were collected from over 1000 sites across the country to assist the process of land characterization and the development of a dynamic and representative overview of land cover and land use in Bangladesh. The system has been applied to the development of a wall-to-wall national land cover map for the year 2015. In this article, the methodological process and results of NLRS formulation and land cover map 2015 are presented. We also provide examples of how this interoperable system and the land cover dataset are being used for variety of applications including national forest resources assessment, estimation of REDD+ activity data, integration of biophysical and socioeconomic information, and semantic similarity assessment