Helping Students Learn through Students Feedback Literacy Method

Feedback is the critical element to improve students’ learning quality. During the ten years, many papers have focused on the students’ feedback literacy (SFL) and teachers’ feedback literacy (TFL). This article aims to systematize the core research concept of different teams and suggest strategies for training SFL. For the qualitative method, the researchers interviewed 26 teachers from two vocational colleges in China. For the quantitative method, the authors analyzed 523 students’ data and questionnaires to determine whether there is significant difference between them. Although there is no significant difference the two college between the south and north part of China, using feedback effectively is an important life skill required to function effectively in the workplace and relationships. We summarize crucial ideas about designing effective feedback strategies throughout the paper. With this in mind, we invite readers to consider what small changes you would make to your practice and how you would share your learning with your colleagues and students.

Case report: Clinical complete response in advanced ALK-positive lung squamous cell carcinoma: a case study of successful anti-PD-1 immunotherapy post ALK-TKIs failure

In patients with advanced lung adenocarcinoma (LADC) harboring the echinoderm microtubule-associated protein-like 4 (EML4) -anaplastic lymphoma kinase (ALK) rearrangement, targeted therapy typically demonstrates superior efficacy as an initial treatment compared to chemotherapy. Following resistance to ALK-tyrosine kinase inhibitors (TKIs), regimens incorporating platinum-based dual agents or combined with bevacizumab often show effectiveness. However, therapeutic alternatives become constrained after resistance develops to both TKIs and platinum-based therapies. Given that the majority of ALK-positive non-small cell lung carcinomas (NSCLC) are LADC, the benefits of TKIs for patients with ALK-positive lung squamous cell carcinoma (LSCC) and the optimal treatment strategy for these patients remain a subject of debate. In this case study, we report on a patient with advanced LSCC, in whom the EML4-ALK rearrangement was identified via ARMS-PCR (Amplification Refractory Mutation System-Polymerase Chain Reaction). The patient underwent oral treatment with crizotinib and alectinib, showing effectiveness in both first-line and second-line ALK-TKI therapies, albeit with limited progression-free survival (PFS). Subsequent resistance to second-generation TKI was followed by the detection of tumors in the left neck region via computed tomography (CT). Biopsy pathology revealed non-squamous cell carcinoma, and subsequent treatment with platinum-based double-drug therapy proved ineffective. Further analysis through next-generation sequencing (NGS) indicated ALK negativity but a high expression of programmed death-ligand 1 (PD-L1). Immunotherapy was then initiated, resulting in a PFS of over 29 months and clinical complete remission (cCR). This case underscores the potential benefit of ALK-TKIs in patients with ALK-positive LSCC. Resistance to second-generation TKIs may lead to ALK negativity and histological transformation, highlighting the necessity of repeated biopsies post-TKI resistance for informed treatment decision-making. As of November 2023, imaging studies continue to indicate cCR in the patient, with a survival time exceeding 47 months

Habitual night sleep duration is associated with general obesity and visceral obesity among Chinese women, independent of sleep quality

PurposeResearch on the relationship between sleep duration and obesity defined using multiple anthropometric and bioelectrical indices in women remains scarce. We aimed to explore the association between sleep duration and body mass index (BMI), waist-hip ratio (WHR), body fat percentage (PBF) and visceral fat area (VFA) among females.MethodsWe recruited women for medical examination using multistage cluster sampling. Sleep was assessed using Pittsburgh Sleep Quality Index (PSQI) and sleep duration was categorized into short (<7 h), optimal (7 <9 h) and long sleep (≥ 9 h). Weight and height were measured using a calibrated stadiometer. Waist circumference was manually measured. PBF, and VFA were estimated by bioelectrical impedance analysis. Data on sociodemographic characteristics and lifestyle factors were also collected and included in the logistic regression models to explore the independent association between sleep duration and obesity defined by different indices.ResultsA total of 7,763 women with a mean age of 42.6 ± 13.5 years were included. The percentage of women reporting short and long sleep was 10.3 and 13.4% respectively. The mean BMI, WHR, PBF and VFA were 23.07 ± 3.30 kg/m2, 0.78 ± 0.06, 32.23 ± 6.08% and 91.64 ± 35.97cm2, respectively. Short sleep was independently associated with 35% (95% CI: 1.05–1.75) increased odds of general obesity (BMI ≥ 28 kg/cm2), and long sleep was associated with 18% (95% CI: 1.01–1.37) increased odds of visceral obesity (VFA > 100 cm2). No association was observed between sleep deprivation or excessive sleep and high WHR or high PBF.ConclusionIn women, short sleep was associated with an increased odds of general obesity, whereas long sleep was associated with an increased odds of visceral obesity. Longitudinal observations are needed to confirm this cross-sectional relationship

Prevalence of hyperuricemia and the population attributable fraction of modifiable risk factors: Evidence from a general population cohort in China

Data on updated hyperuricemia prevalence in Beijing-Tianjin-Hebei (BTH) region in China, which is one of the world-class urban agglomerations, is sparse. Overweight/obesity, alcohol consumption, smoking and sedentary behavior are modifiable risk factors (MRFs) for elevated serum uric acid (SUA), but their population attributable fractions (PAFs) for hyperuricemia is still unclear. Using baseline data from the BTH Physical Examination General Population Cohort, we calculated the crude- and adjusted-prevalence of hyperuricemia based on the 30,158 participants aged 18–80 years. Hyperuricemia was defined as SUA >420 μmol/L in men and >360 μmol/L in women, or currently use of uric acid lowering drugs. Overweight/obesity, alcohol consumption, smoking and sedentary behavior were considered as MRFs and their adjusted PAFs were estimated. The prevalence of hyperuricemia was 19.37%, 27.72% in men and 10.69% in women. The PAFs and 95% confidence intervals for overweight, obesity were 16.25% (14.26–18.25%) and 12.08% (11.40–12.77%) in men, 13.95% (12.31–15.59%) and 6.35% (5.97–6.74%) in women, respectively. Alcohol consumption can explain 4.64% (2.72–6.56%) hyperuricemia cases in men, but with no statistical significance in women. Cigarette smoking contributed to 3.15% (1.09–5.21%) cases in men, but a much lower fraction in women (0.85%, 0.49–1.22%). Compared with sedentary time <2 h per day, the PAFs of 2–4 h, 4–6 h, and more than 6 h per day were 3.14% (1.34–4.93%), 6.72% (4.44–8.99%) and 8.04% (4.95–11.13%) in men, respectively. Sedentary time was not found to be associated with hyperuricemia in women. These findings concluded that hyperuricemia is prevalent in this representative Chinese adult general population with substantial sex difference. Four MRFs (overweight/obesity, alcohol consumption, cigarette smoking and sedentary behavior) accounted for a notable proportion of hyperuricemia cases. The PAF estimations enable the exploration of the expected proportion of hyperuricemia cases that could be prevented if the MRFs were removed, which warrants the public health significance of life-style intervention

Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers.

Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for inducing clinical regressions by targeting tumor-associated antigens (TAA). To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we performed tandem mass spectrometry analysis of HLA class I-bound peptides from 35 PDAC patient tumors. This identified a shared HLA-A*0101 restricted peptide derived from co-transcriptional activator Vestigial-like 1 (VGLL1) as a putative TAA demonstrating overexpression in multiple tumor types and low or absent expression in essential normal tissues. Here we show that VGLL1-specific CTLs expanded from the blood of a PDAC patient could recognize and kill in an antigen-specific manner a majority of HLA-A*0101 allogeneic tumor cell lines derived not only from PDAC, but also bladder, ovarian, gastric, lung, and basal-like breast cancers. Gene expression profiling reveals VGLL1 as a member of a unique group of cancer-placenta antigens (CPA) that may constitute immunotherapeutic targets for patients with multiple cancer types

PID Controller Design for UPS Three-Phase Inverters Considering Magnetic Coupling

In three-phase inverters used in uninterruptible power supplies (UPSs), three-limb inductors and three-limb transformers are commonly used in consideration of cost and size. However, magnetic coupling exists between the three phases of the inverter, which can result in complex models. When instantaneous feedback control strategies are introduced to achieve high quality output waveforms, the transient analysis of the closed-loop inverters becomes difficult. In this paper, the phenomenon of magnetic coupling in three-phase inverters due to three-limb inductors and three-limb transformers is analyzed. A decoupled dynamic model is derived based on the instantaneous symmetrical components transformation, which comprises three decoupled equivalent circuits of instantaneous symmetrical components. Analyses based on this model indicate that magnetic coupling may have a significant impact on the performance of three-phase inverters under unbalanced load conditions and transient responses. For three-phase inverters in UPSs with Proportional-Integral-Differential (PID) closed-loop control strategies, the interactive influence between instantaneous closed-loop regulation and magnetic coupling is researched. Finally, a method of reliability analysis and PID controller design for inverters with magnetic coupling is derived. Simulation and experiment results validate the model and conclusions

The effectiveness of government stock purchase during market crash: Evidence from China

During the Chinese stock market crash in 2015, the Chinese government formed a “national team” to directly purchase stocks of more than 1000 firms. We find that the national team\u27s interventions lower the stock price crash risk for these firms; however, they also increase stock price synchronicity, transaction cost and decrease idiosyncratic information. The stabilizing role of the “national team” disappears in the long run after the crisis period. Firms with more noise traders and a lower level of investor confidence benefit more from the national team ownership, consistent with the conjecture that the national team improves market liquidity and investor confidence

Detection and Classification of Pole-like Landmarks for Domain-invariant 3D Point Cloud Map Matching

In 3D point cloud-based visual self-localization, pole landmarks have a great potential as landmarks for accurate and reliable localization due to their long-term stability under seasonal and weather changes. In this study, we aim to explore the use of recently developed deep learning models for pole classification in the context of pole landmark-based self-localization. Specifically, the proposed scheme consists of two main modules: pole map matching and pole class matching. In the former module, local pole map is constructed and its configuration is compared against a precomputed global pole map. An efficient RANSAC map matching is employed to achieve a good tradeoff between computational efficiency and accuracy. In the latter pole class matching module, the local and global poles paired by the RANSAC map-matching are further compared by means of pole attribute class. To this end, a predefined set of pseudo pole classes is learned via k-means clustering in a self-supervised manner. Experiments using publicly available NCLT dataset showed that the pole-like landmark classification method has an improved effect on the visual self-localization system compared with the baseline method.Comment: 4 pages, 3 figures, 1 table, draft version of a manuscript submitted to ICIVC202

Spatial and Temporal Dynamics of Wetlands in Guangdong-Hong Kong-Macao Greater Bay Area from 1976 to 2019

Wetland ecosystems contain rich natural resources and vital ecological functions, and the investigation of spatial and temporal evolution characteristics of wetlands and their driving factors is critical for the management and conservation of wetlands. This study aimed to explore the spatial and temporal dynamics of wetlands in the Guangdong–Hong Kong–Macao Greater Bay Area (GBA) from 1976 to 2019 using multi-source remote sensing data (DISP KH-9, Landsat, and GaoFen-1), combing with the object-based classification method and landscape invasion index, and further analyze the driving forces affecting the spatial and temporal evolution of wetlands. The results showed that: (1) The total area of wetlands in the GBA showed a trend to first increase and then stabilize from 1976 to 2019. (2) The rapid development of aquaculture led to a continuous increase in aquaculture ponds and offshore aquaculture and a flat change in the middle and late stages, the area of mangroves declined substantially before 2000 and has gradually recovered since then, the invasion of various types of wetlands by built-up land is increasing, and wetlands are becoming increasingly fragmented. (3) The wetland changes in the GBA are the result of a combination of natural factors and human activities. Environmental conditions represent the basis for wetland dynamics, while the population, socio-economics, and policies are important drivers of wetland evolution. The findings will be beneficial to the understanding of wetland dynamic changes in the GBA over the past 40 years, and helpful to the scientific management and sustainable development of wetlands