Enantioselective Copper-Catalyzed Defluoroalkylation Using Arylboronate-Activated Alkyl Grignard Reagents

A copper-catalyzed system has been introduced for the enantioselective defluoroalkylation of linear 1-(trifluoromethyl)­alkenes through C–F activation to synthesize various <i>gem</i>-difluoroalkenes as carbonyl mimics. For the first time, arylboronate-activated alkyl Grignard reagents were uncovered in this cross-coupling reaction. Mechanistic studies confirmed that the tetraorganoborate complexes generated in situ were the key reactive species for this transformation

<i>S</i>‑(Methyl‑<i>d</i>_<i>3</i>) Arylsulfonothioates: A Family of Robust, Shelf-Stable, and Easily Scalable Reagents for Direct Trideuteromethylthiolation

A family of electrophilic deuterated methylthiolating reagents, S-(methyl-d3) arylsulfonothioates, was developed in two or three steps from cheap d4-MeOH in high yields. S-(Methyl-d3) arylsulfonothioates represent a kind of powerful deuterated methylthiolating reagent and allow modular trideuteromethylthiolation with a variety of nucleophiles or electrophiles including aryl(hetero) iodides, boronic acids esters, terminal alkynes, diazonium salts, β-ketoester, and oxindole under mild reaction conditions. A structure–reactivity research (SAR) study was conducted and provided a new avenue for the development of deuterated methylthiolating reagents and efficient methodology for trideuteromethylthiolation

Additional file 1 of Genomics insights into flowering and floral pattern formation: regional duplication and seasonal pattern of gene expression in Camellia

Additional file 1: Fig. S1. The karyotyping and Kmer-based analyses of the cjaND genome. Fig. S2. The Hi-C heatmap shows the interaction of the chromosome. Fig. S3. The segregation patterns of the genetic makers. Fig. S4. The evolution and expression pattern of CjAGs. Fig. S5. Co-expression network analysis of CjAG1 and CjAG2. Fig. S6. Identification of annual rhythmic genes in C. japonica. Fig. S7. Identification of annual rhythmic genes in C. azalea. Fig. S8. The relationship of co-expression module of common rhythmic genes. Fig. S9. The seasonal expression genes participating in different pathways in C. japonica and C. azalea. Fig. S10. Identification of FT genes from C. japonica and C. azalea