The prognostic value of postoperative radiotherapy in right tumor for lung related death: based on SEER database and real-world data

BackgroundPostoperative radiotherapy (PORT) is a therapeutic strategy for patients with non-small cell lung cancer (NSCLC). Nevertheless, some studies suggesting PORT does not improve overall survival (OS) including Lung ART phase III trial. The role of PORT and high-risk groups need to be confirmed.MethodsPatients from the Surveillance, Epidemiology, and End Results program (SEER) from 2004 to 2015 were eligible. Aged ≥18 years with stage IIIA-N2 NSCLC, accepted PORT or not were considered for the study. Cox regression analyses and multivariate competing risk model were performed. Propensity score matching (PSM) was conducted. Data from a single-center study in China were used for validation.ResultsIn all patients with IIIA-N2 NSCLC, death from respiratory illness increased year by year, with right lung-related deaths accounting for the main proportion. In SEER database, PORT was detrimental for OS after PSM (hazard ratio [HR], 1.088; 95% CI, 1.088–1.174; P = 0.031), with a same trend for death from the lungs (HR, 1.13; 95% CI, 1.04–1.22; P = 0.005). Right tumor receiving PORT were prone to death from lung disease(HR, 1.14; 95% CI, 1.02–1.27; P = 0.018). In China single-center cohort, PORT was significantly correlated with deteriorated OS (HR 1.356; 95% CI 1.127–1.632; P <0.01), especially in the right laterality (HR 1.365; 95% CI 1.062–1.755; P = 0.015).ConclusionsPORT was a risk factor for stage IIIA-N2 NSCLC patients, particularly with characters of right laterality, male sex, age ≥65 years, and advanced tumor stage. These patients are more likely to death from lung disease after PORT

Petrogenesis and Tectonic Significance of the ~276 Ma Baixintan Ni-Cu Ore-Bearing Mafic-Ultramafic Intrusion in the Eastern Tianshan Orogenic Belt, NW China

The Baixintan mafic-ultramafic intrusion in the Dananhu-Tousuquan arc of the Eastern Tianshan orogenic belt is composed of lherzolite, olivine gabbro, and gabbro. Olivine gabbros contain zircon grains with a U-Pb age of 276.8 ± 1.1 Ma, similar to the ages of other Early Permian Ni-Cu ore-bearing intrusions in the region. The alkaline-silica diagrams, AFM diagram, together with the Ni/Cu-Pd/Ir diagram, indicate that the parental magmas for the Baixintan intrusion were likely high-Mg tholeiitic basaltic in composition. The Cu/Pd ratios, the relatively depleted PGEs and the correlations between them demonstrate that the parental magmas had already experienced sulfide segregation. The lower CaO content in pyroxenites compared with the Duke Island Alaskan-type intrusion and the composition of spinels imply that Baixintan is not an Alaskan-type intrusion. By comparing the Baixintan intrusion with other specific mafic-ultramafic intrusions, this paper considers that the mantle source of the Baixintan intrusion is metasomatized by subduction slab-derived fluids’ components, which gives rise to the negative anomalies of Nb, Ti, and Ta elements. Nb/Yb-Th/Yb, Nb/Yb-TiO2/Yb, and ThN-NbN plots show that the Baixintan intrusion was emplaced in a back-arc spreading environment and may be related to a mantle plume

Dual effect of radiotherapy related concomitant cardiovascular diseases in non‐small cell lung cancer

Abstract Background Nowadays, cancer and cardiac diseases are two of the most causes of death, so cancer treatment‐related cardiac death cannot be ignored. For lung cancer, chest radiotherapy (RT) is essential, but the related cardiotoxicity has not been fully studied. Methods We reviewed the data of 11,455 patients with non‐small cell lung cancer (NSCLC) from the Surveillance, Epidemiology, and End Results database from 2001 to 2015. The change trend for concomitant cardiovascular diseases (CVD)‐specific death was calculated and graphically demonstrated. Univariate and multivariate analyses for survival were performed using Cox risk regression model. Results In our analysis, the overall incidence and mortality from NSCLC declined, but CVD‐specific death increased. Both chemoradiotherapy and radiotherapy alone played a significant role in CVD‐specific death. Analyzed longitudinally from diagnosis, we found that the effect of RT in CVD‐specific death increased continuously over the third years and the hazard ratio for CVD‐specific death was 1.386 times between RT and non‐RT group (HR = 1.386, 95% CI 1.322–1.452; p < 0.0001). On the other hand, RT played a protective role in CVD‐specific death before the second years, especially in recent years from 2013 to 2015 (HR = 0.843, 95% CI 0.740–0.959; p = 0.009). Conclusions Although the mortality from NSCLC decreased, but radiotherapy‐related CVD‐specific mortality cannot be ignored. In the long‐term over 3 years, RT significantly promoted CVD‐specific death. However, RT turned to be a protective role in the short‐term within 2 years. In clinical practice, we need to comprehensively consider the dual effects of radiotherapy on the side effect of heart

Image_1_Postoperative radiotherapy might be a risk factor for second primary lung cancer: A population-based study.tif

BackgroundSurgery is the main curative therapeutic strategy for patients with initial primary lung cancer (IPLC). Most international guidelines recommend regular follow-ups after discharge to monitor patients for tumor recurrence and metastasis. As the overall survival (OS) in patients with lung cancer improves, their risk of secondary primary lung cancer (SPLC) increases. Previous studies on such patients lack separate assessment of different survival outcomes and evaluation of high-risk factors for SPLC. Therefore, we aimed to determine the correlation between high-risk factors and causes of death in patients with SPLC, based on the Surveillance, Epidemiology, and End Results (SEER) database.MethodsWe screened the SEER database for patients with IPLC and SPLC from 2004 to 2015 and included only patients who underwent surgery since the IPLC and in whom the cancer was pathologically verified of an International Classification of Diseases grade of 0-3 and to be non-small-cell lung cancer. The standardized incidence ratio (SIR) was calculated between variables and SPLC. Multivariable Cox proportional-hazards regression analyses were conducted to calculate the correlation of different variables with overall survival (OS) and cancer-specific survival (CSS). A competing-risk model was conducted for SPLC. The effect of baseline bias on survival outcomes by performing propensity score matching analysis in a 1: 6 ratio (SPLC: IPLC).ResultsFor patients aged 0-49 years, the overall SIR was higher in older patients, reaching a maximum of 27.74 in those aged 40-49 years, and at 11.63 in patients aged 50-59 years. The overall SIR was higher for patients who were more recently diagnosed with IPLC and increased with time after diagnosis. Male sex, SPLC (hazard ratio, 1.6173; 95% confidence interval, 1.5505-1.6869; P ConclusionsPostoperative radiotherapy is a risk factor for second primary lung cancer and detrimental to overall and cancer-specific survival in patients who had initial primary lung cancer. These data support the need for life-long follow-up of patients who undergo treatment for IPLC to screen for SPLC.</p

Optimization of Fermentation Process for New Anti-Inflammatory Glycosylceramide Metabolite from <i>Aspergillus</i> sp.

A novel ceramide compound, named Aspercerebroside A (AcA), was successfully isolated from the ethyl acetate layer of the marine symbiotic fungus Aspergillus sp. AcA exhibited notable anti-inflammatory activity by effectively inhibiting the production of nitric oxide (NO) in RAW 264.7 cells at concentrations of 30 μg/mL and 40 μg/mL, offering a promising avenue for the treatment of inflammatory diseases. To optimize the yield of glycosylceramide (AcA), a series of techniques, including single-factor experiments, orthogonal experiments, and response surface optimization, were systematically employed to fine-tune the composition of the fermentation medium. Initially, the optimal carbon source (sucrose), nitrogen source (yeast extract powder), and the most suitable medium salinity (14 ppt) were identified through single-factor experiments. Subsequently, orthogonal experiments, employing an orthogonal table for planning and analyzing multifactor experiments, were conducted. Finally, a mathematical model, established using a Box–Behnken design, comprehensively analyzed the interactions between the various factors to determine the optimal composition of the fermentation medium. According to the model’s prediction, when the sucrose concentration was set at 37.47 g/L, yeast extract powder concentration at 19.66 g/L, and medium salinity at 13.31 ppt, the predicted concentration of glycosylceramide was 171.084 μg/mL. The experimental results confirmed the model’s accuracy, with the actual average concentration of glycosylceramide under these conditions measured at 171.670 μg/mL, aligning closely with the predicted value