Effect of pore structure on slippage effect in unsaturated tight formation using pore network model

ACKNOWLEDGMENTS We acknowledge the Beijing Natural Science Foundation of China (No. 2204093), Science Foundation of China University of Petroleum, Beijing (No.2462018YJRC033) and financial support from China Scholarship Council ((No. 201906440134)Peer reviewedPostprin

Pore network modeling of thin water film and its influence on relative permeability curves in tight formations

Acknowledgments We acknowledge the Beijing Natural Science Foundation of China (No. 2204093), Science Foundation of China University of Petroleum, Beijing (No.2462018YJRC033) and financial support from China Scholarship Council ((No. 201906440134). Dr. Yingfang Zhou would like to acknowledge the support from State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Southwest Petroleum University), PLN201602.Peer reviewedPostprin

Examining the generalizability of research findings from archival data

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples

Selective applications of excisional surgical treatments of cervical precancers

Cervical precancers encompass high-grade squamous intraepithelial lesion and adenocarcinoma in situ. Treatment of precancerous lesions can reduce cervical cancer mortality and prevent the development of invasive cervical cancer. The choice of treatment regimen needs to follow the principle of individualization and should be based on a combination of factors, including the patient's age, fertility requirements, pregnancy status, pathological type, type of colposcopic transformation zone, patient's follow-up conditions, and the experience of the treating provider. This article presents an opinion regarding the appropriate indications for excisional surgery and total hysterectomy in the management of precancerous lesions of the cervix, with the aim of establishing standardized therapeutic approaches for the treatment of precancerous lesions of the cervix

Fuzzy Inference Full Implication Method Based on Single Valued Neutrosophic t-Representable t-Norm

As a generalization of intuitionistic fuzzy sets, single-valued neutrosophic sets have certain advantages for solving indeterminate and inconsistent information. In this paper, we study the fuzzy inference full implication method based on a single-valued neutrosophic t-representable t-norm. Firstly, single-valued neutrosophic fuzzy inference triple I principles for fuzzy modus ponens and fuzzy modus tollens are shown. Then, single-valued neutrosophic ℛ-type triple I solutions for fuzzy modus ponens and fuzzy modus tollens are given. Finally, the robustness of the full implication of the triple I method based on a left-continuous single-valued neutrosophic t-representable t-norm is investigated. As a special case in the main results, the sensitivities of full implication triple I solutions, based on three special single-valued neutrosophic t-representable t-norms, are given

The relationship between morphology changes and antioxidant enzymes activity during somatic embryogenesis of long-term-maintained callus of Zoysia matrella (L.) Merr.

A callus line of manila grass [Zoysia matrella (L.) Merr.] has been maintained for 8 years in our laboratory. The present study investigated changes in ultrastructure and antioxidant enzyme activity during regeneration of the callus and examined the correlation between these changes and regeneration ability. The changes in fresh weight and diameter of the callus over time could be described by a sigmoidal growth curve with different stages. Electron microscopy revealed small embryonic callus cells, isodiametric in shape, with large, obvious nuclei, and dense cytoplasm. The cellular structures and morphology changed dramatically as regeneration proceeded. Of particular note was the formation of folded scutellum-like embryos at 14 d, which might be the turning point for morphological differentiation. Catalase (CAT) and peroxidase (POD) activities were the lowest at 14 d, the same time when superoxide dismutase (SOD) activity was highest. Thus, we speculate that the formation of the scutellum-like structures is associated with higher activity of SOD and lower activities of CAT and POD.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

The regeneration of bone and tooth tissues, and related cellular therapies, has attracted widespread attention. Bone marrow mesenchymal stem cells (BMSCs) are potential candidates for such regeneration. iRoot SP is a premixed bioceramic root canal sealer widely used in clinical settings. However, the effect of iRoot SP on the biological features of BMSCs has not been elucidated. In the present study, we found that 0.2 mg/ml iRoot SP conditioned medium promoted osteo/odontogenic differentiation and enhanced mineralization of BMSCs without affecting the proliferative ability. Mechanistically, the NF-κB and MAPK signaling pathways were activated in SP-treated BMSCs, and differentiation was inhibited when cultured with the specific inhibitor. Taken together, these findings demonstrate that iRoot SP promotes osteo/odontogenic differentiation of BMSCs via the NF-κB and MAPK signaling pathways, which could provide a new theoretical basis for clinical applications of iRoot SP and a new therapeutic target for the regeneration of bone and tooth tissue in the future