L1L_1-Penalization in Functional Linear Regression with Subgaussian Design

We study functional regression with random subgaussian design and real-valued response. The focus is on the problems in which the regression function can be well approximated by a functional linear model with the slope function being "sparse" in the sense that it can be represented as a sum of a small number of well separated "spikes". This can be viewed as an extension of now classical sparse estimation problems to the case of infinite dictionaries. We study an estimator of the regression function based on penalized empirical risk minimization with quadratic loss and the complexity penalty defined in terms of $L_1$-norm (a continuous version of LASSO). The main goal is to introduce several important parameters characterizing sparsity in this class of problems and to prove sharp oracle inequalities showing how the $L_2$-error of the continuous LASSO estimator depends on the underlying sparsity of the problem

Active Clinical Trials for Personalized Medicine

Individualized treatment rules (ITRs) tailor treatments according to individual patient characteristics. They can significantly improve patient care and are thus becoming increasingly popular. The data collected during randomized clinical trials are often used to estimate the optimal ITRs. However, these trials are generally expensive to run, and, moreover, they are not designed to efficiently estimate ITRs. In this paper, we propose a cost-effective estimation method from an active learning perspective. In particular, our method recruits only the "most informative" patients (in terms of learning the optimal ITRs) from an ongoing clinical trial. Simulation studies and real-data examples show that our active clinical trial method significantly improves on competing methods. We derive risk bounds and show that they support these observed empirical advantages.Comment: 48 Page, 9 Figures. To Appear in JASA--T&

Efficient median of means estimator

The goal of this note is to present a modification of the popular median of means estimator that achieves sub-Gaussian deviation bounds with nearly optimal constants under minimal assumptions on the underlying distribution. We build on a recent work on the topic by the author, and prove that desired guarantees can be attained under weaker requirements