Mean (±SD) plasma concentration–time profiles of 3MBM and 4MBM administered to 12 Sprague–Dawley rats.

<p>Mean (±SD) plasma concentration–time profiles of 3MBM and 4MBM administered to 12 Sprague–Dawley rats.</p

Precursor ion and product ion spectra of 3MBM (a), 4MBM (b) and PPD (c).

<p>Precursor ion and product ion spectra of 3MBM (a), 4MBM (b) and PPD (c).</p

Validation of the intra-day and inter-day assays.

<p>Validation of the intra-day and inter-day assays.</p

Chemical structures of MT (a), PPD (b), 3MBM (c) and 4MBM (d).

<p>Chemical structures of MT (a), PPD (b), 3MBM (c) and 4MBM (d).</p

PK parameters of 3MBM and 4MBM in rat plasma (n = 6, mean ± SD) after oral administration of 3MBM and 4MBM.

<p>PK parameters of 3MBM and 4MBM in rat plasma (n = 6, mean ± SD) after oral administration of 3MBM and 4MBM.</p