Reversible Surface Dual-Pattern with Simultaneously Dynamic Wrinkled Topography and Fluorescence

The reversible surface patterns with fluorescence and topography can possibly enable information recording and reading and provide an important alternative to realize the higher information security. We demonstrated a reversible dual-pattern with simultaneously responsive fluorescence and topography using an anthracene (AN) and naphthalene diimide (NDI) containing copolymer (PAN-NDI-BA) as the skin layer, in which the reversible photodimerization of AN can simultaneously control the cross-linking and CT interaction between AN and NDI. Upon irradiation with UV light and thermal treatment, the resulting pattern assumes a reversible change between smooth and wrinkled states, and its fluorescence changes reversibly from red to white to blue-green. The smart surfaces with dynamic hierarchical wrinkles and fluorescence were achieved by selective irradiation with photomasks and can be employed for potential applications in smart displays and anticounterfeiting

Association of mPRα expression with various clinicopathological characteristics and pathway biomarkers.

<p><i>Kruskal-Wallis</i> test, Chi-square test were used;</p>a<p><i>P</i> values calculated using Fisher’s exact test;</p>b<p>Additional adjusting for age, TNM stage;</p>c<p>TNM stage 0–3 vs. TNM stage 4;</p>d<p>TNM stage 0–2 vs. TNM stage 4;</p>e<p>There were two cases without grade information provided; <i>f</i> There were thirty five cases without the related information provided;</p

Clinicopathologic characteristics and immunohistochemical features of breast cancer patients.

<p>Clinicopathologic characteristics and immunohistochemical features of breast cancer patients.</p

Immunohistochemical stain intensities of mPRα and controls.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035198#pone-0035198-g001" target="_blank">Figure 1A</a> shows the western blot assay of cellular proteins (duplicates) isolated from MB231 and MB231-mPR (mPRα cDNA stably transfected MB231 cells). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035198#pone-0035198-g001" target="_blank">Figure 1B – 1E</a> show the tissue microarray cores that are negative (1B), weak (1C), moderate (1D), and strong positive (1E). The positive stain signals are indicated as black arrows. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035198#pone-0035198-g001" target="_blank">Figure 1F</a> shows a benign breast disease core with weak mPR positive stain in epithelium (black arrow) and strong positive stain in myoepithelium (brown arrow). Image was taken a 20× lens.</p

Correlation between mPRα expression and molecular subtypes of breast cancer.

a<p>p-value from Chi-square test for ER+ vs. HER2+ER–PR–.</p>b<p>p-value from <i>Kruskal-Wallis</i> test for ER+ vs. HER2+ER–PR–.</p

Flow diagram of the selection of eligible studies.

<p>Flow diagram of the selection of eligible studies.</p

Main characteristics of the eligible studies.

<p>Main characteristics of the eligible studies.</p

Meta-analysis results of the associations of decreased LKB1 expression with clinicopathological parameters.

<p>Meta-analysis results of the associations of decreased LKB1 expression with clinicopathological parameters.</p

Funnel plot for the assessment of potential publication bias regarding OS in the meta-analysis.

<p>Funnel plot for the assessment of potential publication bias regarding OS in the meta-analysis.</p

Forest plot describing the association between decreased LKB1 expression and OS.

<p>Forest plot describing the association between decreased LKB1 expression and OS.</p