2 research outputs found
Macrophage Cell Membrane Camouflaged Au Nanoshells for in Vivo Prolonged Circulation Life and Enhanced Cancer Photothermal Therapy
Macrophage cell membrane (MPCM)-camouflaged
gold nanoshells (AuNS)
that can serve as a new generation of photothermal conversion agents
for in vivo photothermal cancer therapy are presented. They are constructed
by the fusion of biocompatible AuNSs and MPCM vesicles. The resulting
MPCM-coated AuNSs exhibited good colloidal stability and kept the
original near-infrared (NIR) adsorption of AuNSs. Because AuNS carried
high-density coverage of MPCMs, the totally functional portions of
macrophage cells membrane were grafted onto the surface of AuNSs.
This surface functionalization provided active targeting ability by
recognizing tumor endothelium and thus improved tumoritropic accumulation
compared to the red blood cell membrane-coating approach. These biomimetic
nanoparticles significantly enhance in vivo blood circulation time
and local accumulation at the tumor when administered systematically.
Upon NIR laser irradiation, local heat generated by the MPCM-coated
AuNS achieves high efficiency to suppress tumor growth and selectively
ablate cancerous cells within the illuminated zone. Therefore, MPCM-coated
AuNSs remained the natural properties of their source cells, which
may improve the efficacy of photothermal therapy modulated by AuNSs
and other noble-metal nanoparticles
Near Infrared Light-Powered Janus Mesoporous Silica Nanoparticle Motors
We describe fuel-free,
near-infrared (NIR)-driven Janus mesoporous
silica nanoparticle motors (JMSNMs) with diameters of 50, 80, and
120 nm. The Janus structure of the JMSNMs is generated by vacuum sputtering
of a 10 nm Au layer on one side of the MSNMs. Upon exposure to an
NIR laser, a localized photothermal effect on the Au half-shells results
in the formation of thermal gradients across the JMSNMs; thus, the
generated self-thermophoresis can actively drive the nanomotors to
move at an ultrafast speed, for instance, up to 950 body lengths/s
for 50 nm JMSNMs under an NIR laser power of 70.3 W/cm<sup>2</sup>. The reversible “on/off” motion of the JMSNMs and
their directed movement along the light gradient can be conveniently
modulated by a remote NIR laser. Moreover, dynamic light scattering
measurements are performed to investigate the coexisting translational
and rotational motion of the JMSNMs in the presence of both self-thermophoretic
forces and strong Brownian forces. These NIR-powered nanomotors demonstrate
a novel strategy for overcoming the necessity of chemical fuels and
exhibit a significant improvement in the maneuverability of nanomotors
while providing potential cargo transportation in a biofriendly manner