Experimental Research on Scour Protection Range and Protection Effect of Large Diameter Monopile Foundation

[Introduction] Under the wave-current combinations during the service period of offshore wind turbine, local scour inevitably occurs around pile foundation, which threatens the overall stability and safety of offshore wind turbine. [Method] In this paper, the normal physical model test at a scale of 1∶30 was carried out for the wind power foundation with a diameter of 8.0 m to study the scour depth, sand cover, solidified soil protection range, and protection effect. [Result] The results show that due to the good hydrodynamic conditions considered in this test, the maximum scour depth is 0.133 cm. In this case, the 1 cm-thick sand cover with a splicing size of 1.0 m×1.0 m can meet the stability requirements. When solidified soil is adopted for protection, the protection range shall not be less than 5 times the pile diameter, and block stones shall be laid at the edge of solidified soil to avoid scouring at the lower part of solidified soil. [Conclusion] The test results can provide reference for scouring test and engineering design of similar projects

A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis.

Temperature controls plant growth and development, and climate change has already altered the phenology of wild plants and crops1. However, the mechanisms by which plants sense temperature are not well understood. The evening complex is a major signalling hub and a core component of the plant circadian clock2,3. The evening complex acts as a temperature-responsive transcriptional repressor, providing rhythmicity and temperature responsiveness to growth through unknown mechanisms2,4-6. The evening complex consists of EARLY FLOWERING 3 (ELF3)4,7, a large scaffold protein and key component of temperature sensing; ELF4, a small α-helical protein; and LUX ARRYTHMO (LUX), a DNA-binding protein required to recruit the evening complex to transcriptional targets. ELF3 contains a polyglutamine (polyQ) repeat8-10, embedded within a predicted prion domain (PrD). Here we find that the length of the polyQ repeat correlates with thermal responsiveness. We show that ELF3 proteins in plants from hotter climates, with no detectable PrD, are active at high temperatures, and lack thermal responsiveness. The temperature sensitivity of ELF3 is also modulated by the levels of ELF4, indicating that ELF4 can stabilize the function of ELF3. In both Arabidopsis and a heterologous system, ELF3 fused with green fluorescent protein forms speckles within minutes in response to higher temperatures, in a PrD-dependent manner. A purified fragment encompassing the ELF3 PrD reversibly forms liquid droplets in response to increasing temperatures in vitro, indicating that these properties reflect a direct biophysical response conferred by the PrD. The ability of temperature to rapidly shift ELF3 between active and inactive states via phase transition represents a previously unknown thermosensory mechanism

Fantasy curiosity:a new theoretical perspective to understand anime pilgrimage

Curiosity stands as a significant driving force in comprehending tourist behaviour. Nonetheless, within the realm of anime pilgrims, the objects of interest, the underlying mechanisms and the resulting behaviours stemming from their curiosity deviate notably from those exhibited by typical tourists. Through the utilization of in-depth case studies of anime pilgrims, this research unveils an innovative impetus for tourism known as ‘fantasy curiosity’ with four distinct attributes, differentiating it from prevailing conceptualizations of general curiosity. Moreover, by utilizing a Latent Dirichlet Allocation model, we pinpoint distinct characteristics of anime-related behaviours across different phases of anime tours. These findings serve to propel the progression of research within the realms of tourism motivations, while concurrently broadening the horizons of curiosity theory.</p

N-Butylphthalide Alleviates Blood-Brain Barrier Impairment in Rats Exposed to Carbon Monoxide

Carbon monoxide (CO) poisoning is one of the most important health concerns and may result in neuropathologic changes and neurologic sequelae. However, few studies have addressed the correlation between CO poisoning and blood-brain barrier (BBB) impairment. In this study, we investigated the effects of N-butylphthalide (NBP) on the expressions of zonula occludens-1 (ZO-1), claudin-5 and aquaporin-4 (AQP-4) proteins in a CO poisoning rat model. The results indicated that the brain water content was obviously increased, and the tight junctions (TJs) between endothelial cells were disrupted, resulting in significant cerebral edema and BBB dysfunction in a rat model of CO poisoning. Meanwhile, the ultrastructure of endothelial cells and pericytes was seriously damaged, and the expressions of ZO-1 and claudin-5 were decreased at an early stage (<7 days). NBP treatment could efficiently maintain the ultrastructural and functional integrity of BBB, alleviate cerebral edema. Besides, NBP could also markedly increase the levels of both ZO-1 and claudin-5 proteins compared with those in rats exposed to CO (P<0.05), whereas NBP had no apparent regulatory effect on AQP-4 expression. Taken together, this study highlights the importance of ZO-1 and claudin-5 proteins in maintaining BBB ultrastructure and function after CO poisoning. NBP, as a novel treatment approach, may effectively inhibit the down-regulation of ZO-1 and claudin-5 proteins (but not AQP-4), thereby preserving the barrier function and reducing cerebral edema after CO poisoning

Mechanisms for Improvement of Weld Appearance in Autogenous Fiber Laser Welding of Thick Stainless Steels

High-power fiber laser welding is an efficient and effective way to produce heavy section structures. However, there is a significant challenge in producing the welds with free of imperfections such as nail-head-shaped welds, spatters, and root sagging. This is partially due to a lack of understanding of the welding mechanism of high-power fiber laser. In this paper, we were especially interested in the mechanism to improve the appearance of welds, and we focused on the autogenous laser welding on thick stainless steel plates by a 10 kW fiber laser. To look into the relations of process parameters and the quality of welds, a high-speed imaging system was applied to observe the molten pool flow and vapor plume during the welding process. The appearances of welds subjected to different welding conditions were analyzed. The results showed that (1) nail-head-shaped welds were suppressed by using a gas jet during laser welding process. (2) In the forward welding, a gentle upwelling molten metal flow on the rear keyhole wall, a deeper weld pool and a weaker vapor plume resulted in no spatter. (3) The gravity affected the formation of underfills and root sagging significantly during autogenous laser welding of thick plates. (4) When the workpiece was placed vertically in the transverse position, the welding process was stable without an aggregation of molten melt at the back surface. Moreover, the mechanisms of forming root sagging and humps were different at the top surface

Microstructure and wear resistance property of laser cladded CrCoNi coatings assisted by ultrasonic impact treatment

In this paper, CrCoNi medium-entropy alloy coatings were prepared by laser cladding process, and ultrasonic impact treatment (UIT) with different impact amplitudes (0 μm, 10 μm, 15 μm, 20 μm) was performed on the coating surface to systematically study the microstructure and properties of the coatings. The results showed that the surface deformation of the coatings became more and more severe with the increase of ultrasonic impact amplitude. After the UIT treatment, the impact layer with obvious plastic deformation appeared on the top of the coating, and the depth of the impact layer gradually increased with the increase of the amplitude, and the influence range of the impact layer could be roughly judged according to the increase of the small-angle grain boundary on the top, which was about 200–400 μm at the amplitude of 20 μm. The grain size was 64.067 μm at an amplitude of 20 μm, which was about 34% of the original size. The microhardness of the coating was found to increase with the impact amplitude, and when the impact amplitude reached 20 μm, the microhardness of the coating reached 374.1 HV0.2, which was 122% higher than that of the unimpacted coating. Also, the wear resistance of the Cr–Co–Ni coating increased with the increase of impact amplitude, and the wear weight loss of the coating increased by 85.71% compared to the untreated specimen at an impact amplitude of 20 μm

Efficacy of Combined XingZhi-YiNao Granules and Hyperbaric Oxygen Therapy for Cognition and Motor Dysfunction in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

Purpose. To investigate the efficacy of XingZhi-YiNao (XZYN) granules and hyperbaric oxygenation (HBO) for cognition and motor dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods. Eighty-nine patients with DEACMP were randomly divided into control group (n=19), HBO group (n=32), and XZYN group (n=38). All patients received conventional treatment. HBO group received HBO therapy once daily. XZYN group received extra XZYN granules plus HBO treatment. The related indexes including activity of daily living (ADL) scale, Montreal cognitive assessment (MoCA) scale, and mini mental state examination (MMSE) scale were measured. Cerebral white matter injury, age related white matter changes (ARWMC) scale, and the amplitude and latency of P300 were assessed. Results. Compared with control group, the neurological function scores of ADL, MoCA, and MMSE in HBO and XZYN groups were significantly improved, the impairment degree of brain white matter and cognition function were obviously alleviated, the latencies of P300 were significantly shortened, and the amplitudes of P300 were evidently increased (P<0.05). Treatment efficacy of XZYN group was superior to that of HBO group (P<0.05). Conclusion. Combined XZYN granules and HBO can significantly improve cognition and motor functions in patients with DEACMP