Focus on China: the current status of entrepreneurship research in China

This review study is a first attempt to map the state of entrepreneurship research in China by focusing on the contributions of Chinese researchers. Leading contributors, research collaboration and theoretical underpinnings in both domestic-oriented and international-oriented research are discussed. The review comprises 508 articles published in domestic Chinese journals indexed by the Chinese Social Science Citation Index and 189 articles published in international journals indexed by the Social Science Citation Index between 2000 and 2011. Two bibliometric approaches, co-authorship analysis and co-citation analysis, were utilized. The results indicate that entrepreneurship research in China is characterized by a clear division, not only in terms of researchers in each community, collaborating network but also with regard to theoretical foundation. Domestic-oriented research is still in its infancy. The research community has attracted a majority of Chinese researchers who focus on inter-institutional collaboration based on mentorship and directing relationship. Scholars involved in international-oriented research engage in more open communication by collaborating not only with researchers from other Chinese institutions but also with those from foreign countries. At the same time, they contribute to the understanding of Chinese entrepreneurship by linking the entrepreneurship phenomenon in Chinese context to theoretical frameworks

City Branding Evaluation as a Tool for Sustainable Urban Growth: A Framework and Lessons from the Yangtze River Delta Region

With the rising tide of globalization, urban branding campaigns have become the focal points of decision makers and planners aiming to establish city reputations and to achieve long-term urban prosperity. This paper, therefore, aims to develop a sustainability-oriented city branding framework that incorporates (1) comprehensive perceptions from various stakeholders through questionnaires and (2) empirical applications that evaluate the city-level potentials for a global mega-region in support of its sustainable growth. Seven major aspects, i.e., economic development, environment, potential, pulse, people, infrastructure, and governance, have been identified and assessed in the context of 26 prefecture cities in the Yangtze River Delta region. Moreover, a cluster analysis differentiated these cities into four groups with distinct characteristics and development paths. Through the framework and evaluation outputs, local planners, researchers, and decision-makers would be better placed to design and implement sustainable policy packages and incentives, with a quantitative insight into current strengths and weaknesses

Zn2+ incorporated composite polysaccharide microspheres for sustained growth factor release and wound healing

The development of new wound dressings has always been an issue of great clinical importance and research promise. In this study, we designed a novel double cross-linked polysaccharide hydrogel microspheres based on alginate (ALG) and hyaluronic acid methacrylate (HAMA) from gas-assisted microfluidics for wound healing. The microspheres from gas-assisted microfluidics showed an uniform size and good microsphere morphology. Moreover, this composite polysaccharide hydrogel microspheres were constructed by harnessing the fact that zinc ions (Zn2+) can cross-link with ALG as well as histidine-tagged vascular endothelial growth (His-VEGF) to achieve long-term His-VEGF release, thus promoting angiogenesis and wound healing. Meanwhile, Zn2+, as an important trace element, can exert antibacterial and anti-inflammatory effects, reshaping the trauma microenvironment. In addition, photo cross-linked HAMA was introduced into the microspheres to further improve its mechanical properties and drug release ability. In summary, this novel Zn2+ composite polysaccharide hydrogel microspheres loaded with His-VEGF based on a dual cross-linked strategy exhibited synergistic antimicrobial and angiogenic effects in promoting wound healing

Hydrogel-based treatments for spinal cord injuries

Spinal cord injury (SCI) is characterized by damage resulting in dysfunction of the spinal cord. Hydrogels are common biomaterials that play an important role in the treatment of SCI. Hydrogels are biocompatible, and some have electrical conductivity that are compatible with spinal cord tissues. Hydrogels have a high drug-carrying capacity, allowing them to be used for SCI treatment through the loading of various types of active substances, drugs, or cells. We first discuss the basic anatomy and physiology of the human spinal cord and briefly discuss SCI and its treatment. Then, we describe different treatment strategies for SCI. We further discuss the crosslinking methods and classification of hydrogels and detail hydrogel biomaterials prepared using different processing methods for the treatment of SCI. Finally, we analyze the future applications and limitations of hydrogels for SCI. The development of biomaterials opens up new possibilities and options for the treatment of SCI. Thus, our findings will inspire scholars in related fields and promote the development of hydrogel therapy for SCI

The 3 May 2006 (M<inf>w</inf> 8.0) and 19 March 2009 (M<inf>w</inf> 7.6) Tonga earthquakes: Intraslab compressional faulting below the megathrust

The Tonga subduction zone is among the most seismically active regions and has the highest plate convergence rate in the world. However, recorded thrust events confidently located on the plate boundary have not exceeded Mw 8.0, and the historic record suggests low seismic coupling along the arc. We analyze two major thrust fault earthquakes that occurred in central Tonga in 2006 and 2009. The 3 May 2006 Mw 8.0 event has a focal mechanism consistent with interplate thrusting, was located west of the trench, and caused a moderate regional tsunami. However, long-period seismic wave inversions and finite-fault modeling by joint inversion of teleseismic body waves and local GPS static offsets indicate a slip distribution centered ~65km deep, about 30km deeper than the plate boundary revealed by locations of aftershocks, demonstrating that this was an intraslab event. The aftershock locations were obtained using data from seven temporary seismic stations deployed shortly after the main shock, and most lie on the plate boundary, not on either nodal plane of the deeper main shock. The fault plane is ambiguous, and investigation of compound rupture involving coseismic slip along the megathrust does not provide a better fit, although activation of megathrust faulting is responsible for the aftershocks. The 19 March 2009 Mw 7.6 compressional faulting event occurred below the trench; finite-fault and W-phase inversions indicate an intraslab, ~50km deep centroid, with ambiguous fault plane. This event also triggered small megathrust faulting. There continues to be a paucity of large megathrust earthquakes in Tonga

Influence of Fault Current and Different Oscillating Magnetic Fields on Electromagnetic–Thermal Characteristics of the REBCO Coil

When the high-temperature superconducting (HTS) REBCO (rare-earth barium copper oxide) coil is applied in a power system, a large amount of heat may be generated due to the short-circuiting of the system, resulting in the thermal instability of the coil. Moreover, under complex working conditions, the oscillating external magnetic field will further aggravate the coil quench. In this paper, the electromagnetic–thermal coupling model is used to analyze the loss, current distribution and temperature distribution of the REBCO coil under short-circuit fault conditions and oscillating external magnetic fields. In order to get closer to the actual situation, the modeling of the superconducting tape adopts the real tape structure, and the resistivity of the superconductor is described by the modified E-J relationship. Four cases are considered for the oscillating external magnetic field, i.e., sine, triangle, sawtooth and square cases. This model has certain significance as a reference for understanding the thermal stability of coils in extreme cases

Influence of Fault Current and Different Oscillating Magnetic Fields on Electromagnetic&ndash;Thermal Characteristics of the REBCO Coil

When the high-temperature superconducting (HTS) REBCO (rare-earth barium copper oxide) coil is applied in a power system, a large amount of heat may be generated due to the short-circuiting of the system, resulting in the thermal instability of the coil. Moreover, under complex working conditions, the oscillating external magnetic field will further aggravate the coil quench. In this paper, the electromagnetic&ndash;thermal coupling model is used to analyze the loss, current distribution and temperature distribution of the REBCO coil under short-circuit fault conditions and oscillating external magnetic fields. In order to get closer to the actual situation, the modeling of the superconducting tape adopts the real tape structure, and the resistivity of the superconductor is described by the modified E-J relationship. Four cases are considered for the oscillating external magnetic field, i.e., sine, triangle, sawtooth and square cases. This model has certain significance as a reference for understanding the thermal stability of coils in extreme cases

Studies on the anti-psoriasis effects and its mechanism of a dual JAK2/FLT3 inhibitor flonoltinib maleate

Psoriasis is a chronic, inflammatory autoimmune disease mediated by T cells, and characterized with abnormal proliferation and differentiation of keratinocytes, and inflammatory infiltration. The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway has been identified to play essential roles in mediating various of biological processes, and is closely related to autoimmune diseases. Dendritic cells (DCs) are important antigen presenting cells and play an important regulatory role in T cells. The proliferation, differentiation and function of DCs are regulated by JAK and FMS-like tyrosine kinase 3 (FLT3) signal pathways. Flonoltinib maleate (FM), a high selectivity dual JAK2/FLT3 inhibitor with IC50 values of 0.8 nM and 15 nM for JAK2 and FLT3, respectively, was developed by our laboratory. Moreover, FM was a potent JAK2 inhibitor with 863-fold and 696-fold selectivity over JAK1 and JAK3, respectively. In this study, the anti-psoriasis activity of FM was evaluated both in vitro and in vivo. FM effectively inhibited the proliferation of HaCaT, the inflammatory keratinocyte induced by M5 and markedly suppressed the generation and differentiation of DCs from bone marrow (BM), and inhibited the expression of FLT3 in DCs in vitro. FM effectively inhibited the ear thickening and improved the pathological changes of the ear in interleukin (IL)-23-induced psoriasis-like acanthosis mouse model. Further in keratin 14-vascular endothelial growth factor (K14-VEGF) transgenic homozygous mice model, FM could obviously improve the psoriatic symptom and pathological changes, significantly inhibit the generations of Th1 and Th17 cells in the spleen, and the accumulations of DCs in the ears. FM could also significantly reduce the expression of various inflammatory factors both in C57BL/6 and K14-VEGF mice ears, and the serum of K14-VEGF mice. Mechanism revealed that FM effectively suppressed the phosphorylation of JAK2, STAT3 and STAT5 in inflammatory keratinocytes and the mice ears of C57BL/6 and K14-VEGF, as well as the phosphorylation of FLT3 in K14-VEGF mice ears. In conclusion, FM plays an excellent anti-psoriasis activity, including inhibiting keratinocyte proliferation and regulating inflammatory response through inhibiting JAK2 and FLT3 signaling pathway

Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis

NLRP3 is an intracellular sensor protein that causes inflammasome formation and pyroptosis in response to a wide range of stimuli. Aberrant activation of NLRP3 inflammasome has been implicated in various chronic inflammatory diseases, making it a promising target for therapeutic intervention. In this work, a series of novel triazinone inhibitors of NLRP3 inflammasome were designed and synthesized. Compound L38 was identified for its excellent activity and acceptable metabolic stability among 41 compounds. Additionally, mechanism studies indicated that L38 inhibited NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly while leaving mitochondrial ROS production, lysosome damage, and chloride/potassium efflux unaffected. Further investigation revealed that L38 could bind to the NACHT domain to exert inflammatory properties. Importantly, L38 exhibited positive therapeutic effects in DSS-induced ulcerative colitis mouse model. Taken together, this study presents a promising inhibitor of NLRP3 inflammasome deserving further investigation