2 research outputs found
Measurement and Correlation of the Solubility of Pyrimethanil in Seven Monosolvents and Two Different Binary Mixed Solvents
The solubility of pyrimethanil in
two binary solvents (water +
methanol and water + ethanol) and seven monosolvents (methanol, ethanol, <i>n</i>-propanol, isopropanol, <i>n</i>-butanol, isobutanol,
and cyclohexane) was measured by a gravimetric method within the temperature
range of 283.15 to 323.15 K at atmospheric pressure. In the investigated
temperature range, the solubility of pyrimethanil in all monosolvents
or mixed solvents increases with increasing temperature. The solubility
in the monosolvents was well-correlated using the NRTL model, the
Apelblat model, and the Wilson model. Furthermore, the NRTL model
and the modified version of the Jouyban–Acree model (the Apel-JA
equation) were employed to correlate the solubility in binary solvents.
The results showed that these models have a satisfactory correlation.
When we measured the solubility, we found that the solvent has a great
influence on the crystal habit. Therefore, these results can give
guidance for practical industrial processes such as the design of
the crystallization process and control of the crystal morphology
Solubility Measurement and Correlation of Fosfomycin Sodium in Six Organic Solvents and Different Binary Solvents at Temperatures between 283.15 and 323.15 K
The
solubility data of fosfomycin sodium (FOM-Na) in six pure solvents
(methanol, ethanol, propanol, cyclohexane, acetone, <i>N</i>,<i>N</i>-dimethylformamide) and two binary solvents (methanol
+ ethanol, methanol + acetone) at temperatures ranging from 283.15
to 323.15 K were measured by a laser monitoring dynamic method at
atmospheric pressure. It turned out that the solubility data decreased
with increasing temperature, and also varies with the composition
of the solvents. Moreover, the experimental data in pure solvents
have been correlated with two thermodynamic models (i.e., modified
Apelblat and van’t Hoff), and the data in binary solvents have
been correlated with CNIBS/R-K equation and two modified versions
of Jouyban–Acree models (Van’t-JA equation and Apel-JA
equation), respectively. All the results showed a good agreement with
the experimental data. Intermolecular interaction force and dielectric
constants are introduced to explain the relationship between solubility
and temperature. In addition, the analysis of the solubilities implies
that higher temperature may destroy the forces between the solvent
and solute molecules, leading to lower solubility. And this can give
a guide to the design and optimization of the crystallization process
of FOM-Na in the industry