Road transport energy consumption in the G7 and BRICS: 1973–2010

Road transport will account for a large share of developing countries’ future energy demand. This paper reviews the trends in road transport energy consumption in 12 countries (Group of Seven (G7) and BRICS) over the period 1973–2010. We report several stylised facts: road transport energy use and its share in total energy use have been rising; there were large differences in road transport energy use per capita across countries, resulting from differences in country size, resource endowments, fuel prices and other factors; oil accounts for around 95% of road transport energy in the selected countries except Brazil; oil will likely be the dominant road transport energy source in most countries for some years to come but not in the long run; and the use of alternative road transport energy sources is increasing.We are thankful for financial support from the ‘Strategic Priority Research Program’ of the Chinese Academy of Sciences (No. XDA05150600), National Natural Science Foundation of China (No. 71322306, 71273027 and 71020107026) and Program for New Century Excellent Talents in University of Ministry of Education of China (No. NCET-13-0040)

Modifying the STM Tip for the ' Ultimate ' Imaging of the Si(111)-7×7 Surface and Metal-supported Molecules

We report on high-resolution STM measurements with modified probe tips. First, both the rest atoms and adatoms of a Si(111)-7×7 surface are observed simultaneously. The visibility of rest atoms is dependent upon the sample bias voltage (less than –0.7 V) and is enhanced by sharpening the tip, which is rationalized by first-principles calculations. Second, a tip with a perylene molecule adsorbed at its apex is used to discriminate the molecular states and the metal states of the underlying Ag(110) surface, which is attributable to a mismatch between the energy levels of the functionalized tip and the adsorbates on silver. Lastly, high-resolution images of iron phthalocyanine (FePc) and zinc phthalocyanine (ZnPc) molecules on Au(111) are obtained by using an O2-terminated tip, and the images reveal rich intramolecular features arising from molecular orbitals that are not observed when using clean metallic tips

Dark matter search with CMB: a study of foregrounds

The energy injected from dark matter annihilation and decay processes potentially raises the ionisation of the intergalactic medium and leaves visible footprints on the anisotropy maps of the cosmic microwave background (CMB). Galactic foregrounds emission in the microwave bands contaminate the CMB measurement and may affect the search for dark matter's signature. In this paper, we construct a full CMB data and foreground simulation based on the design of the next-generation ground-based CMB experiments. The foreground residual after the components separation on maps is fully considered in our data analysis, accounting for various contamination from the emission of synchrotron, thermal dust, free-free and spinning dust. We analyse the corresponding sensitivity on dark matter parameters from the temperature and polarization maps, and we find that the CMB foregrounds leave a non-zero yet controllable impact on the sensitivity. Comparing with statistics-only analysis, the CMB foreground residual leads to a factor of at most 19% weakening on energy-injection constraints, depending on the specific dark matter process and experimental configuration. Strong limits on dark matter annihilation rate and decay lifetime can be expected after foreground subtraction.Comment: 6 figures, 2 tables. The foreground, mask maps and simulated datasets used in this work are available at https://github.com/Junsong-Cang/DM_CMB_Forecas

Searching for Associations Between Short Gamma-ray Bursts and Fast Radio Burst

The physical origin of fast radio bursts (FRBs) is still unclear. However, young magnetars associated with short-duration gamma-ray bursts (SGRBs) have been thought to be possible central engines for some FRBs. In this paper, we perform a systematic search for SGRBs that are associated with FRBs in a sample including 623 FRBs (601 one-off bursts and 22 repeaters) and 168 SGRBs with precise localizations. We find that FRB 190309A is spatially associated with GRB 060502B, with a chance probability of 0.05 when temporal and redshift information is taken into account. Considering the high chance probability (the statistical significance is < 3{\sigma}), we examine other observational properties such as the host galaxy, the dispersion measure, and the energy budget of the central engine to check the possibility of their association. Although the available observational information is insufficient to determine whether they are physically associated, it does not rule out such a possibility. As the only pair of FRB and GRB that are spatially associated, it remains an interesting case worthy of further attentionComment: 19 pages, 4 figures, accepted to Ap

Case Report: Intervention of radiotherapy improves the prognosis of rectal squamous cell carcinoma with high PD-L1 expression and enable patients to obtain NED status

BackgroundRectal squamous cell carcinoma (RSCC) is a rare malignancy of the rectal tumor. Due to its extremely low incidence, there is still a lack of high-level treatment evidence and clinical consensus on this disease.Case reportIn this article, we report a treatment process of RSCC with high PD-L1 expression. Firstly, this patient received 2 cycles of Pembrolizumab immunotherapy, but the efficacy was less sanguine. Subsequently, 4 cycles of mFOLFOX6 chemotherapy were synchronously performed on the basis of the initial regimen. Although partial remission was achieved in the lymph nodes thereafter, the changes in the primary lesions were still not significant. After that, the patient received radiotherapy, and followed by 6 cycles of PC (Albumin-binding Paclitaxel and Nedaplatin) regimen chemotherapy combined with Pembrolizumab. Eventually, the patient achieved no evidence of disease (NED) status, and no signs of recurrence or metastasis were found after 12 months of follow-up.ConclusionThis is the first report of a RSCC patient with high PD-L1 expression achieving a complete response. Looking back over the whole treatment process of this patient, we found that the participation of radiotherapy was the inflection point of prominent efficacy, which may provide a new idea for the selection of comprehensive treatment strategies for patients with RSCC

A genetic study of the NOS3 gene for ischemic stroke in a Chinese population

We recruited 560 unrelated patients with ischemic stroke and 153 unrelated controls to undertake a genetic analysis for association between the NOS3 gene and ischemic stroke. All the subjects were Chinese of Han descent. Because the NOS3 gene spans about 21 kb of DNA and contains 26 exons, we selected a single nucleotide polymorphism (SNP) rs3918181, an A to G base change located in intron 14 of the gene, as a DNA marker. PCR-based restriction fragment length polymorphism analysis was applied to genotype rs3918181 (RsaI site). The chi-square (χ2) goodness-of-fit test showed that the genotypic distributions of the marker were not deviated from Hardy-Weinberg equilibrium in both the patient group (χ2 = 0.166, p = 0.684) and the control group (χ2 = 0.421, p = 0.517). The cocaphase analysis showed allelic association of rs3918181 with ischemic stroke in males (χ2 = 4.04, p = 0.044, OR = 1.43, 95% CI 1.01∼2.02) and frequency of allele A was significantly higher in male patients than male control subjects. The χ2 test revealed genotypic association between rs3918181 and ischemic stroke in males (χ2 = 4.26, df = 1, p = 0.039, OR = 1.61, 95% CI 1.02∼2.53) but not in females. The present work suggests that rs3918181 is associated with ischemic stroke in male patients. This finding gives further evidence in support of the eNOS association with ischemic stroke in the Chinese population

Dependence of the Nonlinear Photoacoustic Response of Gold Nanoparticles on the Heat-Transfer Process

Photoacoustic (PA) imaging using the nonlinear PA response of gold nanoparticles (GNPs) can effectively attenuate the interference from background noise caused by biomolecules (e.g., hemoglobin), thus offering a highly potential noninvasive biomedical imaging method. However, the mechanism of the nonlinear PA response of GNPs based on the thermal expansion mechanism, especially the effect of heat-transfer ability, still lacks quantitative investigation. Therefore, this work investigated the effect of heat-transfer ability on the nonlinear PA response of GNPs using the critical energy and fluence concept, taking into account the Au@SiO2core-shell nanoparticles (weakened heat transfer) and gold nanochains (enhanced heat transfer). The results showed that the stronger the heat transferability, the smaller the critical energy, indicating that the nonlinear PA response of different nanoparticles cannot be contrasted directly through the critical energy. Moreover, the critical fluence can directly contrast the proportion of nonlinear components in the PA response of different GNPs as governed by the combined effect of heat transferability and photothermal conversion ability