Stylizing Face Images via Multiple Exemplars

We address the problem of transferring the style of a headshot photo to face images. Existing methods using a single exemplar lead to inaccurate results when the exemplar does not contain sufficient stylized facial components for a given photo. In this work, we propose an algorithm to stylize face images using multiple exemplars containing different subjects in the same style. Patch correspondences between an input photo and multiple exemplars are established using a Markov Random Field (MRF), which enables accurate local energy transfer via Laplacian stacks. As image patches from multiple exemplars are used, the boundaries of facial components on the target image are inevitably inconsistent. The artifacts are removed by a post-processing step using an edge-preserving filter. Experimental results show that the proposed algorithm consistently produces visually pleasing results.Comment: In CVIU 2017. Project Page: http://www.cs.cityu.edu.hk/~yibisong/cviu17/index.htm

Characterization of small molecules inhibiting the pro-angiogenic activity of the zinc finger transcription factor Vezf1

Discovery of inhibitors for endothelial-related transcription factors can contribute to the development of anti-angiogenic therapies that treat various diseases, including cancer. The role of transcription factor Vezf1 in vascular development and regulation of angiogenesis has been defined by several earlier studies. Through construction of a computational model for Vezf1, work here has identified a novel small molecule drug capable of inhibiting Vezf1 from binding to its cognate DNA binding site. Using structure-based design and virtual screening of the NCI Diversity Compound Library, 12 shortlisted compounds were tested for their ability to interfere with the binding of Vezf1 to DNA using electrophoretic gel mobility shift assays. We identified one compound, T4, which has an IC50 of 20 μM. Using murine endothelial cells, MSS31, we tested the effect of T4 on endothelial cell viability and angiogenesis by using tube formation assay. Our data show that addition of T4 in cell culture medium does not affect cell viability at concentrations lower or equal to its IC 50 but strongly inhibits the network formation by MSS31 in the tube formation assays. Given its potential efficacy, this inhibitor has significant therapeutic potential in several human diseases

Deterministic Polynomial-Time Algorithms for Designing Short DNA Words

Designing short DNA words is a problem of constructing a set (i.e., code) of n DNA strings (i.e., words) with the minimum length such that the Hamming distance between each pair of words is at least k and the n words satisfy a set of additional constraints. This problem has applications in, e.g., DNA self-assembly and DNA arrays. Previous works include those that extended results from coding theory to obtain bounds on code and word sizes for biologically motivated constraints and those that applied heuristic local searches, genetic algorithms, and randomized algorithms. In particular, Kao, Sanghi, and Schweller (2009) developed polynomial-time randomized algorithms to construct n DNA words of length within a multiplicative constant of the smallest possible word length (e.g., 9 max{log n, k}) that satisfy various sets of constraints with high probability. In this paper, we give deterministic polynomial-time algorithms to construct DNA words based on derandomization techniques. Our algorithms can construct n DNA words of shorter length (e.g., 2.1 log n + 6.28 k) and satisfy the same sets of constraints as the words constructed by the algorithms of Kao et al. Furthermore, we extend these new algorithms to construct words that satisfy a larger set of constraints for which the algorithms of Kao et al. do not work.Comment: 27 page

Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification

*Motivation:* In current proteome research, peptide sequencing is probably the most widely used method for protein mixture identification. However, this peptide-centric method has its own disadvantages such as the immense volume of tandem Mass Spectrometry (MS) data for sequencing peptides. With the fast development of technology, it is possible to investigate other alternative techniques. Peptide Mass Fingerprinting (PMF) has been widely used to identify single purified proteins for more than 15 years. Unfortunately, this technique is less accurate than peptide sequencing method and cannot handle protein mixtures, which hampers the widespread use of PMF technique. If we can remove these limitations, PMF will become a useful tool in protein mixture identification. 
*Results:* We first formulate the problem of PMF protein mixture identification as an optimization problem. Then, we show that the use of some simple heuristics enables us to find good solutions. As a result, we obtain much better identification results than previous methods. Moreover, the result on real MS data can be comparable with that of the peptide sequencing method. Through a comprehensive simulation study, we identify a set of limiting factors that hinder the performance of PMF method in protein mixtures. We argue that it is feasible to remove these limitations and PMF can be a powerful tool in the analysis of protein mixtures

Review on UWB Bandpass Filters

Rapid development of a number of wireless communication systems imposed an urgent requirement for a technology which contains multi-wireless communication standard. Since the ultra-wideband (UWB) technologies are of advantage in broad bandwidth and high-speed transmission, much attention has been paid to exploiting the UWB bandpass filters. In this chapter, the development process of the UWB bandpass filters and the regulation of the UWB bandpass filter are initially introduced. Subsequently, the application scenarios of UWB filters in UWB communication systems and unique merits of UWB filters were explored. In addition, the primary performance specifications of the UWB filters, including insertion loss, return loss, the level of out-of-band attenuation, and roll-off rate, are also presented. After a brief discussion of microwave network theory, several methods for implementing UWB filters are summarized. Furthermore, the design of the UWB filter with notch band is presented in Section 5. The last section, the Conclusion section, is given at the end of this chapter