Correlation of ADC values of the whole osteosarcomas with necrosis rates after neoadjuvant chemotherapy.

<p>Correlation of ADC values of the whole osteosarcomas with necrosis rates after neoadjuvant chemotherapy.</p

Osteosarcoma of the distal femur in a 46-year-old woman with poor response.

<p>(<b>A∼C</b>) DWI map, ADC map and ADC histogram before neoadjuvant chemotherapy. The tumor on DWI map was mixed high signal intensity. The ADC value of the whole tumor was 1.35×10⁻³ mm²/s with a subtotal green area. The ADC histogram was high and sharp. (<b>D∼F</b>) DWI map, ADC map and ADC histogram after neoadjuvant chemotherapy. The tumor on DWI map was mixed signal intensity. The ADC value of the whole tumor (1.31×10⁻³ mm²/s) and the ADC histogram were similar to those of pre- neoadjuvant chemotherapy. Tumor necrosis rate of 20% was confirmed by postoperative pathological evaluation. The effectiveness of neoadjuvant chemotherapy was poor.</p

Tumor size and volume at pre- and post-chemotherapy.

<p>Tumor size and volume at pre- and post-chemotherapy.</p

Osteosarcoma of the distal femur in a 24-year-old man with good response.

<p>(<b>A∼C</b>) DWI map, ADC map and ADC histogram before neoadjuvant chemotherapy. The signal intensity of tumor on DWI map was high. The ADC value of the whole tumor was 1.12×10⁻³ mm²/s with a green area. The ADC histogram was high and sharp. (<b>D∼F</b>) DWI map, ADC map and ADC histogram after neoadjuvant chemotherapy. The signal intensity of tumor on DWI map was decreased. The ADC value of the whole tumor was increased to 1.99×10⁻³ mm²/s with a subtotal red area. The ADC histogram was short, wide and moving to the right of the coordinate. Tumor necrosis rate of 92% was confirmed by postoperative pathological evaluation. The effectiveness of neoadjuvant chemotherapy was good.</p

Mean ADC values of whole tumor at pre- and post-chemotherapy (×10⁻³ mm²/s).

<p>Mean ADC values of whole tumor at pre- and post-chemotherapy (×10⁻³ mm²/s).</p