DataSheet1_The Mediating Role of Extra-family Social Relationship Between Personality and Depressive Symptoms Among Chinese Adults.docx

Objectives: This study aims to explore the associations of personality traits and extra-family social relationship with depressive symptoms among Chinese adults.Methods: A nationally representative sample of 29,810 adults aged 16 and above were selected from 2018 CFPS. Personality and depressive symptoms were measured using CBF-PI-15 and the CES-D8 scale. Extra-family social relationship was assessed through the self-rated evaluation. The multiple regression analysis and the PROCESS macro were used for the mediation analysis.Results: Extraversion (OR = 0.807, 95% CI = 0.773, 0.842), agreeableness (OR = 0.795, 95% CI = 0.756, 0.835) and extra-family social relationship (OR = 0.927, 95% CI = 0.913, 0.941) had negative associations with depressive symptoms. Extra-family social relationship could mediate between extraversion and depressive symptoms (Indirect effect = −0.049,95% CI = −0.060, −0.039) as well as agreeableness (Indirect effect = −0.056, 95% CI = −0.068, −0.046) and depressive symptoms. Comparing to females, the indirect effect accounts for a higher proportion of total effect in males.Conclusion: Extra-family social relationship might mediate the association between extraversion and depressive symptoms as well as agreeableness and depressive symptoms.</p

Gender-specific association of metabolic syndrome and its components with arterial stiffness in the general Chinese population

<div><p>Objectives</p><p>Metabolic syndrome (MS) is considered to be a cluster of interrelated risk factors for metabolism, which may increase arterial stiffness and cardiovascular morbidity. The cardio-ankle vascular index (CAVI) is a reliable indicator of arterial stiffness and early arteriosclerosis. The main objective of this study is to evaluate the gender-specific relationship between MS and CAVI in the general Chinese population.</p><p>Methods</p><p>A total of 1,301 subjects aged 20 to 60 years participated in this study. CAVI was measured noninvasively using a Vasera VS-1000 device. Blood samples and waist circumference were examined to identify metabolic syndrome according to the criteria set forth in the 2009 Joint Scientific Statement.</p><p>Results</p><p>The prevalence of MS in the study subjects was 17.4% (30.7% in males and 7.0% in females, P < 0.001). CAVI values were significantly higher in MS subjects than in non-MS subjects and increased linearly as the number of MS components increased in females, but not in males. Using multiple regression analysis, we found that BMI was correlated with CAVI in the overall population and in both genders, and that high-density lipoprotein cholesterol (HDL-C) was associated with CAVI in males, while the number of MS components was related to CAVI in females. CAVI values increased linearly with age in both genders (P-trend < 0.001 for both), and this correlation was stronger in males than in females.</p><p>Conclusions</p><p>There are gender-specific differences in the association of MS and CAVI. First, the effects of the number of MS components on CAVI are stronger in females than in males. Second, the effect of each MS component on arterial stiffness may differ in relation to gender. In addition, aging affects arterial stiffness more severely in males, and the increase in arterial stiffness tends to occur at a younger age in males than in females. Larger samples and longitudinal studies are needed to further confirm our results in the future.</p></div

Pearson’s correlation coefficients between MS components and CAVI.

<p>Pearson’s correlation coefficients between MS components and CAVI.</p

Baseline characteristics of subjects.

<p>Baseline characteristics of subjects.</p

Characteristics of subjects stratified by sex and the presence/absence of metabolic syndrome.

<p>Characteristics of subjects stratified by sex and the presence/absence of metabolic syndrome.</p

Trend test of CAVI values with the number of MS components in males and females.

<p>The solid lines show the differences between the groups in males, and the dotted line is the trendline for females. * <i>P</i> < 0.05 in males.</p

Trend test of CAVI values with age in males and females.

<p>The solid line is the trendline for males, and the dotted line is the trendline for female.</p

Multiple linear regression models evaluating the associations of MS components and CAVI.

<p>Multiple linear regression models evaluating the associations of MS components and CAVI.</p

Trend test of AC with the number of MS components in males and females.

<p>The solid line is the trendline for males, and the dotted line is the trendline for females.</p