THE PROSPECT, PROMISES AND HINDRANCES OF STATIN BASE MOLECULES: LOOK BACK TO LOOK FORWARD

This review narrates the importance of the statin-based molecules and their inherent challenges during their administration. The chronological appearance of the statin, their source and the journey with time so to evolve as one of the successful cholesterol-lowering agents to prevent the morbidity and mortality especially related to coronary heart disease have been illustrated along with their recent utilities in neurodegenerative diseases. The statins, because of their respective physicochemical characters pose several challenges in regards to their effective administration to the patients. One of the major issues related their poor bioavailability is their aqueous solubility. The different approaches for the enhancement of solubility and hence bioavailability have been discussed systematically. This review finally suggests the importance of more related research in regards to their successful administration so to have greater realization of therapeutics efficiency.Keywords: Statin-based molecules, Poor solubility, Solubility enhancemen

Studies on Water-Polymer Interactions inthe Presence of Aceclofenac at 298.15 K

Densities and ultrasonic velocities of aqueous mixtures of methyl cellulose (MC) and polyethylene glycol (PEG) and of methyl cellulose and hydroxyl propyl methyl cellulose (HPMC), over the compositions, 9:1, 8:2 and 6:4, and of MC, HPMC and PEG, over the compositions, 9:0.5:0.5, 8:1:1 and 6:2:2, have been measured with and without acelofenac at 298.15K and at atmospheric pressure. The experimental ultrasonic velocities have been used to determine isentropic compressibilities, apparent isentropic molar compressibilities, acoustic impedance, molar compressibility, molar sound velocity, free volume and relative association for the systems with and without aceclofenac. The results have been discussed in terms of solute solvent and solute-solute interactions and various structural effects

Conductometric Study of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures

Conductance values of nimesulide have been determined in water in 0.1, 0.2, 0.4, 0.6, 0.8, 1 and 2 mol dm-3 aqueous solutions of hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at temperatures 298.15, 303.15, 308.15 and 313.15 K. The conductance values have been used to evaluate the limiting molar conductance and association constants by means of Shedlovsky extrapolation technique. Thermodynamic parameters for the association process of nimesulide in aqueous solutions of hydrotropic agents have also been calculated

Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application

Box-Behnken (BBD) and central composite rotatable designs (CCRD) were used as statistical multivariate methods in the formulation optimization of fullerene loaded nano-emulsions. Effect of palm kernel oil ester (10-20%, w/w), emulsifier (5-10%, w/w) and xanthan gum (0.6-1.0%, w/w) as formulation variables on the particle size, ζ-potential and viscosity of the nano-emulsions were investigated. Under the optimum conditions, CCRD model predicted the response values for particle size, ζ-potential and viscosity were 153.6. nm, -53.4. mV and 42.1. Pa. s, respectively. Nonetheless, BBD model suggested that the optimum conditions for a fullerene loaded nano-emulsion would gave particle size, ζ-potential and viscosity of 151.6. nm, -53.8. mV and 43.1. Pa. s, respectively. The actual response according to suggested compositions for both models showed excellent agreement with the predicted value with residual standard error (RSE) of less than 4%. Optimum nano-emulsions were stable during storage at 25 and 45. °C for 90 days and freeze-thaw cycle

Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene

This research aims to formulate and to optimize a nanoemulsion-based formulation containing fullerene, an antioxidant, stabilized by a low amount of mixed surfactants using high shear and the ultrasonic emulsification method for transdermal delivery. Process parameters optimization of fullerene nanoemulsions was done by employing response surface methodology, which involved statistical multivariate analysis. Optimization of independent variables was investigated using experimental design based on Box–Behnken design and central composite rotatable design. An investigation on the effect of the homogenization rate (4,000–5,000 rpm), sonication amplitude (20%–60%), and sonication time (30–150 seconds) on the particle size, ζ-potential, and viscosity of the colloidal systems was conducted. Under the optimum conditions, the central composite rotatable design model suggested the response variables for particle size, ζ-potential, and viscosity of the fullerene nanoemulsion were 152.5 nm, –52.6 mV, and 44.6 pascal seconds, respectively. In contrast, the Box–Behnken design model proposed that preparation under the optimum condition would produce nanoemulsion with particle size, ζ-potential, and viscosity of 148.5 nm, –55.2 mV, and 39.9 pascal seconds, respectively. The suggested process parameters to obtain optimum formulation by both models yielded actual response values similar to the predicted values with residual standard error of <2%. The optimum formulation showed more elastic and solid-like characteristics due to the existence of a large linear viscoelastic region

Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures

The present study deals with experiments so as to highlight the solute (drug nimesulide) - solvent(water) interactions and related modifications in case of the presence of hydrotropic agents at different temperatures T(=298.15 to 313.15)K. Density and viscosity values of nimesulide have been determined in water in (0.1, 0.2, 0.4, 0.6, 0.8, 1 and 2) mol dm-3 aqueous solutions of hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at temperatures 298.15, 303.15, 308.15 and 313.15 K where as the solubility was studied at 308.15 K. From the density values, the limiting partial molar volumes and expansibilities have been calculated. The experimental viscosity values have been analyzed in terms of jones-dole equation and on the basis of transition theory for relative viscosity

Studies on Water-Polymer Interactions inthe Presence of Aceclofenac at 298.15 K

Densities and ultrasonic velocities of aqueous mixtures of methyl cellulose (MC) and polyethylene glycol (PEG) and of methyl cellulose and hydroxyl propyl methyl cellulose (HPMC), over the compositions, 9:1, 8:2 and 6:4, and of MC, HPMC and PEG, over the compositions, 9:0.5:0.5, 8:1:1 and 6:2:2, have been measured with and without acelofenac at 298.15K and at atmospheric pressure. The experimental ultrasonic velocities have been used to determine isentropic compressibilities, apparent isentropic molar compressibilities, acoustic impedance, molar compressibility, molar sound velocity, free volume and relative association for the systems with and without aceclofenac. The results have been discussed in terms of solute solvent and solute-solute interactions and various structural effects