1 research outputs found
Fluoride Anions in Self-Assembled Chiral Cage for the Enantioselective Protonation of Silyl Enol Ethers
The potential of Song’s
chiral oligoethylene glycols (oligoEGs) as catalysts was explored
in the enantioselective protonation of trimethylsilyl enol ethers
in combination with alkali metal fluoride (KF and CsF) and in the
presence of a proton source. Highly enantioselective protonations
of various silyl enol ethers of α-substituted tetralones were
achieved, producing chiral α-substituted tetralones in full
conversion and with up to 99% ee. The established protocol was successfully
extended to the synthesis of biologically relevant chiral α-substituted
chromanone and thiochromanone derivatives