1 research outputs found
Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimerās Disease
Mitochondrial oxidative stress is
a key pathologic factor in neurodegenerative
diseases, including Alzheimerās disease. Abnormal generation
of reactive oxygen species (ROS), resulting from mitochondrial dysfunction,
can lead to neuronal cell death. Ceria (CeO<sub>2</sub>) nanoparticles
are known to function as strong and recyclable ROS scavengers by shuttling
between Ce<sup>3+</sup> and Ce<sup>4+</sup> oxidation states. Consequently,
targeting ceria nanoparticles selectively to mitochondria might be
a promising therapeutic approach for neurodegenerative diseases. Here,
we report the design and synthesis of triphenylphosphonium-conjugated
ceria nanoparticles that localize to mitochondria and suppress neuronal
death in a 5XFAD transgenic Alzheimerās disease mouse model.
The triphenylphosphonium-conjugated ceria nanoparticles mitigate reactive
gliosis and morphological mitochondria damage observed in these mice.
Altogether, our data indicate that the triphenylphosphonium-conjugated
ceria nanoparticles are a potential therapeutic candidate for mitochondrial
oxidative stress in Alzheimerās disease