Additional file 2: of Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis

Includes a table describing the characteristics of the included studies. (DOC 96 kb

Polypills Meta-analysis ‘PRISMA’ Flow Diagram.

<p>Polypills Meta-analysis ‘PRISMA’ Flow Diagram.</p

Actual vs Expected Reductions in Systolic Blood Pressure and LDL-cholesterol in Trials of ‘Polypills’.

*<p>rounded to nearest 10 mm Hg;</p>**<p>based on mean baseline SBP &amp; standard dose equivalence (from Law 2009) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052145#pone.0052145-Law1" target="_blank">[4]</a>;</p>∧<p>mean baseline LDL × percentage reduction in LDL cholesterol for the statin at that dose (from Law 2003) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052145#pone.0052145-Law2" target="_blank">[5]</a></p>#<p>estimate: two drugs at half dose therefore an overestimate of likely effect;</p>##<p>estimate: two drugs at half dose therefore an underestimate of likely effect; 12.7 mmHg for two drugs at standard dose;</p>β<p>estimate: three drugs at standard dose; 15.2 mmHg for three drugs at half standard dose.</p

Forest Plots of Polypills versus Control for Change in Total Cholesterol and LDL-cholesterol.

<p>Forest Plots of Polypills versus Control for Change in Total Cholesterol and LDL-cholesterol.</p

Forest Plots of Polypills versus Control for Change in Discontinuation of Study Medication and Side Effects.

<p>Forest Plots of Polypills versus Control for Change in Discontinuation of Study Medication and Side Effects.</p

Baseline Characteristics and Study Quality of included Randomised Controlled Trials.

*<p>BP not assessed in meta-analysis as both arms contained an anti-hypertensive;</p>**<p>Following placebo 12 weeks of cross-over RCT;</p>#<p>Double-blind 9-arm with varying medication components and number of components. Only three arms were used in this meta-analysis: the polycap, aspirin and simvastatin arms;</p><p>BP = blood pressure and measured in mmHg; SBP = systolic blood pressure; DBP = Diastolic blood pressure; Total chol. = total cholesterol in mmol/L; LDL = LDL cholesterol in mmol/L; AE = adverse events; TLC = therapeutic lifestyle changes; SD = standard deviation; CVD = cardiovascular disease.</p

Identification process for eligible studies.

<p>Identification process for eligible studies.</p

Quality assessment of included studies.

<p>Quality assessment of included studies.</p

Characteristics of the studies included in the systematic review and meta-analysis.

<p>Characteristics of the studies included in the systematic review and meta-analysis.</p

Forrest plot of the included studies showing relative risk of Mediterranean diet compared to control diet by various outcome measures (Fixed effects model analysis).

<p>Forrest plot of the included studies showing relative risk of Mediterranean diet compared to control diet by various outcome measures (Fixed effects model analysis).</p