PediDraw: A web-based tool for drawing a pedigree in genetic counseling-0

<p><b>Copyright information:</b></p><p>Taken from "PediDraw: A web-based tool for drawing a pedigree in genetic counseling"</p><p>http://www.biomedcentral.com/1471-2350/8/31</p><p>BMC Medical Genetics 2007;8():31-31.</p><p>Published online 8 Jun 2007</p><p>PMCID:PMC1904184.</p><p></p> graph connected by the relationship lines. The symbols used in this graph are accepted in a standardized pedigree as described by Bennett, et al. [1

Flowchart of PPI Finder system.

<p>PPI Finder system includes two modules: Information Retrieval (IR module) and Information Extraction (IE module). The relationships of the tables and the data structures are described in the text.</p

Demonstration of the output results of PPI Finder.

<p>Step 1: Our favourite protein name “dysbindin” is searched by selecting “Gene Name”. Step 2: Three results of “dysbindin” are returned. The first row showing “DTNBP1” is the one that unifies the protein name to a unique gene ID. Step 3: By clicking the “DTNBP1” gene, the gene-centred page is shown. The summary of the information of the “DTNBP1” gene is shown on the top. Step 4: The 35 co-occurred genes and their co-occurrence times, PPI database evidences, and gene ontologies are shown at the bottom of the gene-centred page with the co-occurred GO terms highlighted. Step 5: By clicking the hyperlink to “5” in the column of “co-occurrence times” of the fourth co-occurred “SNAPIN” gene, it prompts the co-occurred abstracts and the highlighted words of interaction extraction in the abstracts.</p

PPI Database Evidence Evaluation.

<p>PPI Database Evidence Evaluation.</p

Co-occurrence Evaluation.

<p>Co-occurrence Evaluation.</p

Architecture of the backend and frontpage of PPI Finder.

<p>The backend depicts the structure of IR module as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004554#pone-0004554-g001" target="_blank">figure 1</a>. The frontpage of PPI Finder includes two web applications: PPI Finder (searching one gene at a time) and Paired-PPI Finder (searching two genes at a time). The output format of PPI Finder is summarized.</p

Specificity Evaluation.

<p>Specificity Evaluation.</p

Sensitivity Evaluation.

<p>Sensitivity Evaluation.</p

Spontaneous Uphill Movement and Self-Removal of Condensates on Hierarchical Tower-like Arrays

Fast removal of condensates from surfaces is of great significance due to the enhanced thermal transfer coefficient and continuous condensation. However, the lost superhydrophobicity of lotus leaves intrigues us to determine what kind of surface morphologies meets the self-removal of condensates? The uphill movement of condensates in textured surfaces is vital to avoid flooding and facilitating self-removal. Here, superhydrophobic microtower arrays were designed to explore the spontaneous uphill movement and Wenzel to Cassie transition as well as the self-removal of condensates. The tower-like arrays enable spontaneous uphill movement of tiny condensates entrapped in microstructures due to the large upward Laplace pressure, which is ∼30 times larger than that on cone-like arrays. The sharp tips decrease the adhesion to suspending droplets and promote their fast self-removal. These results are important for designing desirable textured surfaces by enlarging upward Laplace pressure to facilitate condensate self-removal, which is widely applied in self-cleaning, antifogging, anti-icing, water harvesting, and thermal management systems

Three-Dimensional Crystalline/Amorphous Co/Co₃O₄ Core/Shell Nanosheets as Efficient Electrocatalysts for the Hydrogen Evolution Reaction

Earth-abundant, low-cost electrocatalysts with outstanding catalytic activity in the electrochemical hydrogen evolution reaction (HER) are critical in realizing the hydrogen economy to lift our future welfare and civilization. Here we report that excellent HER activity has been achieved with three-dimensional core/shell Co/Co₃O₄ nanosheets composed of a metallic cobalt core and an amorphous cobalt oxide shell. A benchmark HER current density of 10 mA cm^–2 has been achieved at an overpotential of ∼90 mV in 1 M KOH. The excellent activity is enabled with the unique metal/oxide core/shell structure, which allows high electrical conductivity in the core and high catalytic activity on the shell. This finding may open a door to the design and fabrication of earth-abundant, low-cost metal oxide electrocatalysts with satisfactory hydrogen evolution reaction activities