N–O Tethered Carbenoid Cyclopropanation Facilitates the Synthesis of a Functionalized Cyclopropyl-Fused Pyrrolidine

We report a facile approach to a cyclopropyl-fused pyrrolidine, which contains four stereogenic centers, by employing the N–O tethered carbenoid methodology. The synthesis was facilitated by the development of a direct Mitsunobu reaction of alcohols with <i>N</i>-alkyl-<i>N</i>-hydroxyl amides to give diazo precursors, which upon intramolecular cyclopropanation yielded a library of N–O containing cyclopropyl-fused bicyclic intermediates. Elaboration of the N–O moiety of one member of this library resulted in the formation of the desired pyrrolidine ring demonstrating the potential of this methodology for making cyclopropyl-fused heterocycles

Table_1_An evaluation method for product design solutions for healthy aging companionship.pdf

BackgroundWith the development trend of healthy aging and intelligent integration, escort products have become a new means of healthy aging. Healthy old-age care pays attention to the convenience and informatization of life. To meet the needs, designers often design multiple accompanying product solutions, and it is very important to use reasonable evaluation methods to decide on the optimal solution.PurposesA new comprehensive evaluation method is proposed to reduce the subjectivity and one-sidedness of the selection process of intelligent escort product design solutions, and to make the decision more objective and reasonable. Such decisions can enhance the experience and naturalness of the elderly using intelligent products.MethodsFirst, a large number of user interviews were analyzed using the grounded theory, gradually refine through theoretical coding, and abstracted with the design scheme evaluation index. Second, the idea of game-theoretic weighting is used to optimize a linear combination of subjective and objective weights to determine the final weights of each evaluation indicator. Finally, the evaluation and selection are completed based on the solution ranking determined by the approximate ideal solution ranking method (TOPSIS). It is applied for the selection of the elderly escort robot design, and the usability test is conducted using the PSSUQ to verify the selection results.ResultsA new comprehensive evaluation method can better complete the preferential selection of product design solutions for healthy aging escorts, and reduce the subjectivity and one-sidedness of the evaluation.ConclusionThis method compensates for the reliance on personal experience in the selection of options, and improve the subjectivity of the evaluation index determination process and the deviation of index weighting. Improving the objectivity and scientificity of decision-making reduces the blindness of design and production. It also provides a theoretical reference for the research scholars of healthy aging companion products.</p

Construction of Three-Dimensional Cobalt(II)-Based Metal–Organic Frameworks by Synergy between Rigid and Semirigid Ligands

Solvothermal assembly of Co­(II) ion, a semirigid tetrahedral carboxylate ligand tetrakis­[(4-carboxyphenyl)­oxamethyl]­methane acid (H₄L), and rigid linear bidentate linker 1,4-di­(1<i>H</i>-imidazol-1-yl)­benzene (dib) or 4,4′-di­(1<i>H</i>-imidazol-1-yl)-1,1′-biphenyl (dibp) yields four novel metal–organic frameworks (<b>1</b>–<b>4</b>) with different topological connections. [Co₂(L)­(dib)]·3DMF (<b>1</b>) is a 2-fold interpenetrating <i>sqc</i>422 network and contains 3-dimensional interconnected channels along [100], [010], and [110] directions; [Co₄(L)₂(dib)₃(H₂O)₄]·4H₂O (<b>2</b>) is a three-dimensional 3,4,4-connected new topology with 5-fold interpenetration; [Co₂(L)­(dibp)]·5DMF (<b>3</b>) and Co₂(L)­(dibp)₂ (<b>4</b>) are formed in the presence of dibp linker; they feature three-dimensional novel topologies based on 4,6-connection and 4,4-connection, respectively, and no interpenetration is observed. It is demonstrated that interpenetration is accessible simply by changing auxiliary ligands and solvents. Magnetic studies reveal that complexes <b>1</b> and <b>3</b> exhibit antiferromagnetic behavior

Construction of Three-Dimensional Cobalt(II)-Based Metal–Organic Frameworks by Synergy between Rigid and Semirigid Ligands

Solvothermal assembly of Co­(II) ion, a semirigid tetrahedral carboxylate ligand tetrakis­[(4-carboxyphenyl)­oxamethyl]­methane acid (H₄L), and rigid linear bidentate linker 1,4-di­(1<i>H</i>-imidazol-1-yl)­benzene (dib) or 4,4′-di­(1<i>H</i>-imidazol-1-yl)-1,1′-biphenyl (dibp) yields four novel metal–organic frameworks (<b>1</b>–<b>4</b>) with different topological connections. [Co₂(L)­(dib)]·3DMF (<b>1</b>) is a 2-fold interpenetrating <i>sqc</i>422 network and contains 3-dimensional interconnected channels along [100], [010], and [110] directions; [Co₄(L)₂(dib)₃(H₂O)₄]·4H₂O (<b>2</b>) is a three-dimensional 3,4,4-connected new topology with 5-fold interpenetration; [Co₂(L)­(dibp)]·5DMF (<b>3</b>) and Co₂(L)­(dibp)₂ (<b>4</b>) are formed in the presence of dibp linker; they feature three-dimensional novel topologies based on 4,6-connection and 4,4-connection, respectively, and no interpenetration is observed. It is demonstrated that interpenetration is accessible simply by changing auxiliary ligands and solvents. Magnetic studies reveal that complexes <b>1</b> and <b>3</b> exhibit antiferromagnetic behavior

Reconstructed attenuation (<i>left</i>, by UKF) and activity maps of the patient by UKF (<i>middle</i>) and FBP (<i>right</i>), and the associated color scales.

<p>Reconstructed attenuation (<i>left</i>, by UKF) and activity maps of the patient by UKF (<i>middle</i>) and FBP (<i>right</i>), and the associated color scales.</p

Reconstructed attenuation map of the physical phantom by EKF (<i>left</i>) and UKF (<i>right</i>), and the associate color scale.

<p>Reconstructed attenuation map of the physical phantom by EKF (<i>left</i>) and UKF (<i>right</i>), and the associate color scale.</p

RMSE values of estimated activity maps for the synthetic data.

<p>RMSE values of estimated activity maps for the synthetic data.</p

Reconstructed activity map of the physical phantom by FBP (<i>top left</i>), EM-ML (<i>top right</i>), EKF (<i>bottom left</i>) and UKF(<i>bottom right</i>) (arrows indicate cold areas), and the associated color scale.

<p>Reconstructed activity map of the physical phantom by FBP (<i>top left</i>), EM-ML (<i>top right</i>), EKF (<i>bottom left</i>) and UKF(<i>bottom right</i>) (arrows indicate cold areas), and the associated color scale.</p

MOESM1 of Development of a novel strategy for fungal transformation based on a mutant locus conferring carboxin-resistance in Magnaporthe oryzae

Additional file 1.  Primers used in this study

Synthetic Data.

<p>Top: Horizontal profiles along the (<i>left</i>), (<i>middle</i>), and (<i>right</i>) rows of the recovered activity maps for low count measurements. Bottom: Horizontal profiles along the (<i>left</i>), (<i>middle</i>), and (<i>right</i>) rows of the recovered activity maps for high count measurements.</p