SAR Studies on the Inhibitors for the Treatment of Inflammatory Diseases

School of Molecular Sciences(Chemistry)Inflammation is defensive host response that occurs from infection and injury and the inflammatory process is the pivotal physiological response of our body and essential part of the human physiology. Due to the mechanistic relationship between chronic diseases and inflammation, a better understanding for the molecular mechanism of chronic inflammation could attenuate cellular inflammation pathways. Under inflammatory pathways, the impetus of proinflammatory mediators usually caused by the increased expression of transcriptional factors which is also a potential targets in the development of novel and effective anti-inflammatory therapeutics. Among others, we are interested in the Nuclear Factor Kappa-B (NF-??B) which is reported as a major mediator that regulates inflammatory gene expression and also decrease the prevalence of inflammation responses. To suppress the inflammatory activity, inhibitors that could selectively target this protein are needed. We therefore, chose the natural product cerulenin which has been studied widely because of its antifungal and antibacterial properties, for designing inhibitors. In light of the interesting inhibitory properties displayed by cerulenin for fatty acid synthase (FASN), we were keen to explore the possible binding mode of this natural product with a view to design various derivatives that would be amicable to synthetic manipulation in order to enable SAR studies. Potent analogues of cerulenin, with various chain lengths and substitutions, are synthesized and evaluated for their ability to inhibit NF-??B enhanceosome. Taken together, by identifying target protein with constructed inhibitors derived from cerulenin might give revolutionary effect on discovering new therapeutic agents.ope

A solvent-free Diels-Alder reaction of graphite into functionalized graphene nanosheets

A solvent-free Diels-Alder reaction was carried out by heating a mixture of graphite and a typical dienophile, maleic anhydride (MA) or maleimide (MI), in a sealed glass ampoule of argon. The functionalization of graphite with dienophiles was confirmed by various characterization techniques, suggesting the efficient functionalization and delamination of graphite into a few layers of graphitic nanosheets.close0

Anxiety and Learning in Dynamic and Static Clock Game Experiments

In clock games, agents receive differently-timed private signals when an asset value is above its fundamental. The price crashes to the fundamental when K of N agents have decided to sell. If selling decisions are private, bubbles can be sustained because people delay selling, after receiving signals, knowing that others will delay too. Our results replicate the main features of the one previous experimental study of clock game (in two subject pools): Selling delays are shorter than predicted, but converge toward equilibrium predictions over repeated trials. We also find that delays are shorter in a dynamic game in which selling decisions unfold over time, compared to a static equivalent in which subjects precommit to selling decisions. A model of learning with growing anxiety after signal arrival can reproduce the empirical observations of shorter-than-predicted delay, smaller delay after later signal arrival, and shorter delays in dynamic games

A master\u27s recital in piano

On March 14, 2014, Min Jeong Kim presented a recital in completion of her Master’s degree in Piano Performance. The recital was held at 6 p.m. in Davis Hall at the University of Northern Iowa School of Music. Pieces on the program included: Prelude and Fugue in C minor, BWV 871 by Johann Sebastian Bach, Klavierstücke, Op. 118 by Johannes Brahms, Rain Tree Sketch II by Toru Takemitsu, and Sonata in E-flat Major, Op. 81a by Ludwig van Beethoven