5 research outputs found
Analyzing Collective Motion with Machine Learning and Topology
We use topological data analysis and machine learning to study a seminal
model of collective motion in biology [D'Orsogna et al., Phys. Rev. Lett. 96
(2006)]. This model describes agents interacting nonlinearly via
attractive-repulsive social forces and gives rise to collective behaviors such
as flocking and milling. To classify the emergent collective motion in a large
library of numerical simulations and to recover model parameters from the
simulation data, we apply machine learning techniques to two different types of
input. First, we input time series of order parameters traditionally used in
studies of collective motion. Second, we input measures based in topology that
summarize the time-varying persistent homology of simulation data over multiple
scales. This topological approach does not require prior knowledge of the
expected patterns. For both unsupervised and supervised machine learning
methods, the topological approach outperforms the one that is based on
traditional order parameters.Comment: Published in Chaos 29, 123125 (2019), DOI: 10.1063/1.512549
Dynamics, Networks, and Information: Methods for Nonlinear Interactions in Biological Systems
In this dissertation, we investigate complex, non-linear interactions in biological systems.This work is presented as two independent projects.
The mathematics and biology in each differ, yet there is a unity in that both frameworks are interested in biological responses that cannot be reduced to linear causal chains, nor can they be expressed as an accumulation of binary interactions.
In the first part of this dissertation, we use mathematical modeling to study tumor-immune dynamics at the cellular scale.Recent work suggests that LSD1 inhibition reduces tumor growth, increases T cell tumor infiltration, and complements PD1/PDL1 checkpoint inhibitor therapy.
In order to elucidate the immunogenic effects of LSD1 inhibition, we create a delay differential equation model of tumor growth under the influence of the adaptive immune response in order to investigate the anti-tumor cytotoxicity of LSD1-mediated T cell dynamics.
We fit our model to the B16 mouse model data from Sheng et al. [DOI:10.1016/j.cell.2018.05.052]
Our results suggest that the immunogenic effect of LSD1 inhibition accelerates anti-tumor cytoxicity.
However, cytotoxicity does not seem to account for the slower growth observed in LSD1 inhibited tumors, despite evidence suggesting immune-mediation of this effect.
In the second part, we consider the partial information decomposition (PID) of response information within networks of interacting nodes, inspired by biomolecular networks.We specifically study the potential of PID synergy as a tool for network inference and edge nomination.
We conduct both numeric and analytic investigations of the \Imin and \Ipm PIDs, from [arXiv:1004.2515] and [DOI:10.3390/e20040297], respectively.
We find that the synergy suffers from issues of non-specificity, while synergy is specific but somewhat insensitive.
In the course of our work, we extend the and PIDs to continuous variables for a general class of noise-free trivariate systems.
The PID does not respect conditional independence, while does, as demonstrated through asymptotic analysis of linear and non-linear interaction kernels.
The technical results of this chapter relate the analytic and information-theoretic properties of our interactions, by expressing the continuous PID of noise-free interactions in terms of the partial derivatives of the interaction kernel