18 research outputs found
Great obstetric syndromes: βgordian knotβ of genetic networks
The article discusses modern views on the possible role of various genetic networks in the pathogenesis of βGreat obstetric syndromesβ. The genes of thrombophilia, folate cycle, detoxification system, renin-angiotensin-aldosterone system, immunological response, energy metabolism and endothelial dysfunction are considered. The phenotypic implementation of genetic polymorphisms is discussed.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π²Π·Π³Π»ΡΠ΄Ρ Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ ΡΠΎΠ»Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΡΠ΅ΠΉ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π±ΠΎΠ»ΡΡΠΈΡ
Π°ΠΊΡΡΠ΅ΡΡΠΊΠΈΡ
ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠ². Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π³Π΅Π½Ρ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΠ»ΠΈΠΈ, ΡΠΎΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π°, ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ, ΡΠ΅Π½ΠΈΠ½Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½-Π°Π»ΡΠ΄ΠΎΡΡΠ΅ΡΠΎΠ½ΠΎΠ²ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°, ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΈ Β«Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈΒ» ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ Π΄ΠΈΡΠΊΡΡΡΠΈΠΎΠ½Π½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ²
The role molecular-genetic factors in the development of the weakness of labor in first labor women
Objective: The study of energy metabolism of the myometrium at coordinated (MRC) and the weak labor activity (Wed), identify molecular-genetic predictors of uterine inertia. Subject and methods. In a prospective cohort study included 110 nulliparous women, the clinical course of labor allocated to two groups: I (main) - births proceeded from the weakness of labor (n=62), II (comparison group) - coordinated labor (n=48). A molecular genetic study of polymorphism of genes of the energy exchange method of pyrosequencing. Results. Morphological studies showed the presence of a disturbance of cellular energy metabolism of the myocytes with Wed. Revealed a protective role of genotypes at the polymorphic marker gene PPARA2498 G>C, variant allele T of the polymorphism in the PPARD -87, both homozygous variants PPARGC A203P1Π genotypes GG and SS for Wed. Conclusion. The results of the study can contribute to predicting the weakness of labor in young somatically healthy with physiological pregnancy first labor women.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΡ ΠΏΡΠΈ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ (ΠΠ Π) ΠΈ ΡΠ»Π°Π±ΠΎΠΉ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ (Π‘Π Π), Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ»Π°Π±ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄. Π ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 110 ΠΏΠ΅ΡΠ²ΠΎΡΠΎΠ΄ΡΡΠΈΡ
ΠΆΠ΅Π½ΡΠΈΠ½, ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΎΠ΄ΠΎΠ² Π²ΡΠ΄Π΅Π»Π΅Π½Ρ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ: I (ΠΎΡΠ½ΠΎΠ²Π½Π°Ρ) - ΡΠΎΠ΄Ρ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π»ΠΈ ΡΠΎ ΡΠ»Π°Π±ΠΎΡΡΡΡ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ {n=62), II (Π³ΡΡΠΏΠΏΠ° ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ) - Ρ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ (ΠΏ=48). ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ² ΡΠ½Π΅ΡΠ³ΠΎΠΎΠ±ΠΌΠ΅Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΈΡΠΎΡΠ΅ΠΊΠ²ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΡΠ²Π»Π΅Π½Π° ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½Π°Ρ ΡΠΎΠ»Ρ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² ΠΏΠΎ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΠΎΠΌΡ ΠΌΠ°ΡΠΊΠ΅ΡΡ Π³Π΅Π½Π° PPARA2498 G>C ΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π»Π»Π΅Π»Ρ Π’ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° PPARD -87, ΠΎΠ±Π° Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² PPARGC1Π Π203Π Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² GG ΠΈ Π‘Π‘ Π΄Π»Ρ Π‘Π Π. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΠ³ΡΡ Π²Π½Π΅ΡΡΠΈ ΡΠ²ΠΎΠΉ Π²ΠΊΠ»Π°Π΄ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ»Π°Π±ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Ρ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Ρ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΡΡ ΠΏΠ΅ΡΠ²ΠΎΡΠΎΠ΄ΡΡΠΈΡ
ΠΆΠ΅Π½ΡΠΈΠ½
Analysis of the effectiveness of aspirin for the prevention of preeclampsia and alternative methods of prevention
Purpose of the study. Based on the scientific literature, to evaluate the effectiveness of aspirin in the prevention of preeclampsia and to determine the possible reasons for the lack of effectiveness of such preventionΠ¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠ½ΠΎΠ²ΡΠ²Π°ΡΡΡ Π½Π° Π΄Π°Π½Π½ΡΡ
Π½Π°ΡΡΠ½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°ΡΠΏΠΈΡΠΈΠ½Π° ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΏΡΠ΅ΡΠΊΠ»Π°ΠΌΠΏΡΠΈΠΈ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΠΏΡΠΈΡΠΈΠ½Ρ ΠΎΡΡΡΡΡΡΠ²ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°ΠΊΠΎΠΉ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊ
Possibilities of personified prediction the formation of the primary powerless labour and severity
According to the literature of domestic and foreign authors in obstetric practice from all anomalies of labor, the primary weakness of labor remains one of the leading causes of perinatal morbidity and mortality. Purpose: determination of the possibility of personalized prediction of primary weakness of patrimonial activity and its severity based on the study of clinical, mitochondrial, molecular genetic factors to improve the outcome of urgent labor. Material and methods. Clinical and laboratory indicators of 287 pregnant women in the term of a gestation 39 weeks and 4 days - 40 weeks are investigated. Research SDG, a-GFDG carried out by a cytochemical method to R.P. Nartsissov's modifications (1969). The miometriya and placentae conducted an electronic and microscopic research in an electronic microscope of 'Morgagni 268-Dβ at working increase from 2200 to 22000. The molecular and genetic research PPARA, PPARD, PPARG, PPARGC 1 A, PPARGC 1Π and AMPD was conducted by a pirosekvinirovaniye method with use of system of the genetic analysis of the PyroMark Q24 series. Results of a research. As a result of the work, two models for predicting the primary weakness of labor and severity ware proposed on the basis of a complex of clinical, biophysical, biochemical, molecular genetic, functional research methods to improve the outcome of timely delivery in young primiparous women. Conclusion. A new personalized model for predicting the primary weakness of labor activity provides a scientific, legal and clinical basis for the formation of a reasonable program for the completion of pregnancy.Π‘ΠΎΠ³Π»Π°ΡΠ½ΠΎ Π΄Π°Π½Π½ΡΠΌ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
Π°Π²ΡΠΎΡΠΎΠ² Π² Π°ΠΊΡΡΠ΅ΡΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΈΠ· Π²ΡΠ΅Ρ
Π°Π½ΠΎΠΌΠ°Π»ΠΈΠΉ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΡΠ»Π°Π±ΠΎΡΡΡ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΡΡΠ°Π΅ΡΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π»ΠΈΠ΄ΠΈΡΡΡΡΠΈΡ
ΠΏΡΠΈΡΠΈΠ½ ΠΏΠ΅ΡΠΈΠ½Π°ΡΠ°Π»ΡΠ½ΠΎΠΉ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΈ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ. Π¦Π΅Π»Ρ: ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΡΠ»Π°Π±ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈ Π΅Π΅ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
, ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΡ
, ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π΄Π»Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΈΡΡ
ΠΎΠ΄Π° ΡΡΠΎΡΠ½ΡΡ
ΡΠΎΠ΄ΠΎΠ². ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ 287 Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Π² ΡΡΠΎΠΊΠ΅ Π³Π΅ΡΡΠ°ΡΠΈΠΈ 39 Π½Π΅Π΄Π΅Π»Ρ ΠΈ 4 Π΄Π½Ρ - 40 Π½Π΅Π΄Π΅Π»Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π‘ΠΠ, Π°-ΠΠ€ΠΠ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠΈΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π² ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π .Π. ΠΠ°ΡΡΠΈΡΡΠΎΠ²Π° (1969). ΠΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎ-ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΡ ΠΈ ΠΏΠ»Π°ΡΠ΅Π½ΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π² ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΌ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠ΅ Β«Morgagni 268-DΒ» ΠΏΡΠΈ ΡΠ°Π±ΠΎΡΠ΅ΠΌ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΠΎΡ 2200 Π΄ΠΎ 22000. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ PPARA, PPARD, PPARG, PPARGC1Π, PPARGC1Π ΠΈ AMPD ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΈΡΠΎΡΠ΅ΠΊΠ²ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΡΠΈΡΡΠ΅ΠΌΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠ΅ΡΠΈΠΈ PyroMark Q24. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΡΠΏΠΎΡΠΎΠ±Ρ Π°Π½ΡΠ΅Π½Π°ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΡΠ»Π°Π±ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈ Π΅Π΅ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ Ρ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
ΠΏΠ΅ΡΠ²ΠΎΡΠΎΠ΄ΡΡΠΈΡ
ΠΆΠ΅Π½ΡΠΈΠ½. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎΠ²Π°Ρ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΡΠ»Π°Π±ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ Π½Π°ΡΡΠ½ΡΡ, ΡΡΠΈΠ΄ΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΎΡΠ½ΠΎΠ²Ρ Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π·Π°Π²Π΅ΡΡΠ΅Π½ΠΈΡ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ
The Entangling of Problems, Solutions and Markets: On building a market for privacy
An increasing number of public problems have been subject to market-based interventions as solutions. However, the relationship between problems and solutions in market-based interventions is complex. On occasions solutions are reformulated as understanding of the nature of the problem are advanced. Alternatively, problems are reconfigured to fit a standard solution. Or solutions are said to generate numerous new problems. The complex entangling of problems, solutions and markets can be explored by focusing on the field of online privacy. The complexities of this field can be analysed through three STS treatments of problems and solutions. First, issue-problematisation can be used to understand the ways in which a problem is assembled and comes to form the focus for discussion as an issue can be explored. Second, a paradigm-exemplar approach can assess the extent to which a particular coupling of problem and solution becomes an exemplar for others to draw on. Third, ontological constitution provides a focal point for analysing the ways in which the very nature of entities involved in problems, solutions and markets can be considered. There is analytic utility in each of these approaches in engaging with online privacy regulation and the emerging role of start-ups in introducing new privacy products to an emerging market place. However, these STS approaches leave us with questions regarding the relationship between market solutions and publics, the co-ordination of entities in market solutions and the normative questions that arise from entangling markets, problems and solutions
Clinical and anamnestic and biological candidates for participation in the mechanisms of genital prolapse formation in women
Introduction. The article presents an overview of the results of modern evidence-based scientific research on the mechanisms of formation of genital prolapse as one of the fundamental causes of pelvic floor muscle insufficiency in women. A systematic analysis of the current literature data on the involvement of clinical, anamnestic and pathogenetic motives in the development of pelvic organ prolapse in women was carried out. Objective: to expand the understanding of the role of anamnestic and biological factors in the pathogenesis of genital prolapse in womenΠ¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΡΠ°ΡΡΠΈΡΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΎ ΡΠΎΠ»ΠΈ Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΠΏΡΠΎΠ»Π°ΠΏΡΠ° Π³Π΅Π½ΠΈΡΠ°Π»ΠΈΠΉ Ρ ΠΆΠ΅Π½ΡΠΈ
Improving logging process efficiency in the context of rational natural resource management
Until recently, only the trunk was recognized as valuable in the forest industry, and everything else, including the crown, was considered waste that cluttered cutting areas, and a hazardous raw material in the event of possible fires. Currently, only about 700 thousand tons of wood waste is used, which is no more than 4% of the resulting amount of potential raw materials that could be used at wood processing enterprises. Analysis of formation and use of logging waste showed that today coniferous greenery has found its application as a raw material for coniferous flour production directly at the cutting area. After the needles are separated, branches that have not found further use remain in the cutting area. One of the promising areas for logging waste use after needle separation is production of wood flour, which has found its wide application in many industries
Effect of temperature on the dynamic properties of mixed surfactant adsorbed layers at the water/hexane interface under low-gravity conditions
An increase in temperature typically leads to a decrease in the interfacial tension of a water/oil interface. The addition of surfactants to the system can complicate the situation significantly, i.e., the interfacial tension can increase or decrease with an increasing temperature. For most concentrations of the two studied surfactants, the cationic tetradecyl trimethyl ammonium bromide (TTAB) and the nonionic tridecyl dimethyl phosphine oxide (C13DMPO), the measured interfacial tension of the aqueous mixed surfactant solutions against hexane increases when the temperature decreases between 30Β°C and 20Β°C. However, with a further temperature decrease between 20Β°C and 15Β°C, the reverse effect has also been observed at some concentrations, i.e., a decrease of interfacial tension. Additionally, the corresponding dilational interfacial visco-elasticity shows some discrepant temperature effects, depending on the bulk concentration and oscillation frequency. The experiments have been performed with a capillary pressure tensiometer under the conditions of micro-gravity. The reason for the positive and negative interfacial tension and visco-elasticity gradients, respectively, within certain ranges of the temperature, concentration and mixing ratios, are discussed on the basis of all available parameters, such as the solubility and partitioning of the surfactants in the two liquid phases and the oscillation frequency