Impaired Insulin sensitivity and Insulin secretion in Haemodialysis patients with and without Secondary Hyperparathyroidism

The aim of our study was to investigate insulin sensitivity and beta cell function in hemodialysis (HD) patients without diabetes. We hypothesized that parathyroid gland function was a determinant of insulin sensitivity and/or beta cell function. The study was a randomized, cross-sectional one and patients were divided into two groups (total 27 patients), Gp.1 being those with relative hypoparathyroidism (iPTH<200 pg/ml) ­ 9 (33.3%), Gp.2 those with hyperparathyroidism (iPTH200 pg/ml) ­ 18 (66.6%) with Gp.3 (consisting of 43 healthy subjects acting as controls). Insulin resistance and insulin secretion were calculated from fasting serum insulin and glucose concentrations by the Homeostatic Model Assessment score (HOMA IR and HOMA BETA). The value of HOMA IR (3.28±1.3 for Gp.1, 4.80±2.4 for Gp.2, 1.70±0.8 for Gp.3) as well as the glucose level (5.0±1.0mmol/l in Gp.1, 5.2±0.8mmol/ l in Gp.2, 4.6±0.4mmol/l in Gp.3) was significantly higher in HD patients than in control subjects. Excessive insulin secretion was present in HD patients (as assessed by HOMA BETA) significantly higher only in Gp.1 (p=0.02).peer-reviewe

Acute coronary syndrome in diclofenac sodium-induced type I hypersensitivity reaction : Kounis syndrome

Drug-induced type I hypersensitivity reactions are frequent. Sometimes, acute coronary syndrome (ACS) can be registered in such patients, which may have a serious impact on the course and management of the allergic reaction. Because of potentially atypical ACS clinical presentations, the ECG is an obligatory diagnostic tool in any allergic reaction. Coronary artery spasm is the pathophysiological basis of ACS, triggered by the action of potent vasoactive mediators (histamine, neutral proteases, arachidonic acid products) released from the cells involved in type I hypersensitivity. Allergic angina and allergic myocardial infarction are referred to as Kounis Syndrome. We describe herein a case of ACS in a patient with registered systemic immediate hypersensitivity reaction which developed following the muscular administration of diclofenac sodium.peer-reviewe

Virtual environment in control and programming system for reconfigurable machining robot

Robotski obradni sustavi imaju značajnu ulogu u modernoj proizvodnji. Radom se predlaže primjena virtualnih robota za off-line programiranje. Prikazan je rekonfigurabilni robot za obradu, programiran u G-kôdu, koji se može izravno koristiti od strane programera i operatora CNC alatnih strojeva. Predmet istraživanja su petoosni i šestoosni roboti vertikalne zglobne konfiguracije koji mogu biti konfigurirani tako da emuliraju alatne strojeve s petoosnim vertikalnim i horizontalnim gibanjem glavnog vretena. Razmatrani obradni sustavi su podržani ekvivalentnim virtualnim robotima u CAD/CAM okruženju i sustavu upravljanja. U cilju demonstracije učinkovitosti predložene arhitekture, obrađeno je nekoliko probnih izradaka.Robotic machining systems play an important role in modern manufacturing. The paper proposes the application of virtual robots for off-line programming. The reconfigurable machining robot, programmed in G-code, which can be directly used by CNC machine tool programmers and operators, is presented. The subject of study are 5- and 6-DOF vertical articulated robots that can be configured to emulate vertical and horizontal 5-axis spindle tilting machine tools. The considered machining systems are supported by equivalent virtual robots in the CAD/CAM environment and control system. Several test workpieces were machined to demonstrate the effectiveness of the proposed architecture

Ash Dust Concentration in the Vicinity of the Ash Disposal Site Depending on the Size of the Pond (Water Mirror)

Thermal power plants Nikola Tesla A and B are large sources of ash from their ashes/slag deposit sites Total sizes of ashes/slag depots are 600ha and 382ha, with active cassettes having dimensions similar to 200 ha and similar to 130 ha The active cassettes of the disposal sites are covered by rather large waste ponds the sizes of vary depending on the working condition of a sluice system and on meteorological conditions Modeling of ash lifting was attempted using results from the dust lifting research The relation between sizes of ponds and air dust concentration in the vicinity of ash disposal sites was analyzed As expected, greater sizes of dried disposal site surfaces in combination with stronger winds gave greater dust emission and greater air dust concentratio

Between Hegel, Solovyev and Freud: `Mitrinovic's Philosophy of History

This chapter discusses Dimitrije Mitrinović’s philosophy of history and his (geo)political views, and maintains that he built on Hegel’s philosophy, refracted through Vladimir Solovyev and Sigmund Freud, in order to create a theological topography, in which humanity achieves its synthesis in the form of the Kingdom on Earth, and a historical topography, in which this synthesis is imagined as the triumph of Socialism and European Federation led by the British Empire