62 research outputs found
Isometry invariance of exact correlation functions in various charts of Minkowski and de Sitter spaces
We consider quantum field theory with selfinteractions in various patches of
Minkowski and de Sitter space-times. Namely, in Minkowski space-time we
consider separately right (left) Rindler wedge, past wedge and future wedge. In
de Sitter space-time we consider expanding Poincare patch, static patch,
contracting Poincare patch and global de Sitter itself. In all cases we
restrict our considerations to the isometry invariant states leading to
maximally analytic propagators. We prove that loop corrections in right (left)
Rindler wedge, in the past wedge (of Minkowski space-time), in the static patch
and in the expanding Poincare patch (of de Sitter space-time) respect the
corresponding isometries of the corresponding symmetric space-times. All these
facts are related to the causality and analyticity properties of the
propagators for the states that we consider. At the same time in the future
wedge, in the contracting Poincare patch and in global de Sitter space-time
infrared effects violate the isometries.Comment: 35 pages, 6 figures Additional references and minor clarifications
added; version accepted to PR
Banks: Old Actors of the New Economy
In the globalization conditions, influence of business both on the states internal life, and on the global system increases. The states are compelled to solve together not only the international problems, but also the tasks, which were mainly internal as long ago as yesterday. An increasing number of the public relations go beyond the national borders, and their regulation is possible only by the states interaction. In this paradigm, the banks, as the central players of the national financial system, can become agents of the new economic policy that seeks to find answers to the new global challenges. It is, above all, the banks role in stimulating the national industry, the possibility of the banks participation in the formation of the new truly competitive economy of the medium and small businesses, directed not on the maximum profit extraction, but first on the public interests satisfaction. In the article, the banks activity change in present period is considered. The banks activity transformation requires the change of the regulation measures, including the states interaction in the globalization conditions. The problems description of the modern Russian banking system in the crisis conditions is given and the possible directions of these problems solution are presented.
Keywords: commercial banks, policy, the Bank of Russia, globalization
JEL Classifications: E44, E58, E62, F20, F37, F4
Modern antiepileptic drugs in treatment of focal forms of epilepsy in children
Purpose: Comparison of the efficiency and safety of using antiepileptic drugs topiramate and lamotrigine in treatment of symptomatic focal forms of epilepsy in children. Methods: We observed 2 groups of children with focal forms of epilepsy: 1 group - 31 patient were treated by topiramate in doses from 56 up to 500 mg/day, from 2,8 up to 17 mg/kg/day (on the average 6,6 mg/kg/day). 2 group - 31 patients - received therapy by lamotrigine in doses from 25 up to 250 mg/day, from 0,5 up to 6 mg/ kg/day (on the average 3,6 mg/kg/day). The therapy was used in monotherapy and in combine therapy with other antiepileptic drugs. Results: Seizures freedom was achieved in 8/31 patients (26 %), used topiramate, and in 8/31 patients (26 %), treated by lamotrigine. Reduction in seizure frequency more than 50% was observed in 19/31 (61%) cases in topiramate group and in 14/31 (45%) cases in lamotrigine group. In 3 patients was detected seizures aggravation (in 3% cases, used topiramate and in 6% cases, used lamotrigine). Conclusion: This study has shown topiramate and lamotrigine is high effective new antiepileptic drug for treatment focal forms of epilepsy in children.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°Π½ΡΠΈΠ·ΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΠΎΠΏΠΈΡΠ°ΠΌΠ°ΡΠ° ΠΈ Π»Π°ΠΌΠΎΡΡΠΈΠ΄ΠΆΠΈΠ½Π° Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΠΎΠΊΠ°Π»ΡΠ½ΡΡ
ΡΠΎΡΠΌ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ. ΠΠ΅ΡΠΎΠ΄Ρ: ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈΡΡ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΎΠΊΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ. 1 Π³ΡΡΠΏΠΏΠ° Π²ΠΊΠ»ΡΡΠ°Π»Π° 31 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΡΠΎΠΏΠΈΡΠ°ΠΌΠ°ΡΠΎΠΌ Π² Π΄ΠΎΠ·Π°Ρ
ΠΎΡ 56 ΠΌΠ³/ΡΡΡΠΊΠΈ Π΄ΠΎ 500 ΠΌΠ³/ΡΡΡΠΊΠΈ, ΠΎΡ 2,8 ΠΌΠ³/ΠΊΠ³/ΡΡΡΠΊΠΈ Π΄ΠΎ 17 ΠΌΠ³/ΠΊΠ³/ΡΡΡΠΊΠΈ (Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ ΡΠΎΡΡΠ°Π²Π»ΡΡ 6,6 ΠΌΠ³/ΠΊΠ³/ΡΡΡΠΊΠΈ). 2 Π³ΡΡΠΏΠΏΠ° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΊΠ»ΡΡΠ°Π»Π° 31 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π»Π°ΠΌΠΎΡΡΠΈΠ΄ΠΆΠΈΠ½ΠΎΠΌ Π² Π΄ΠΎΠ·Π°Ρ
ΠΎΡ 25 ΠΌΠ³/ΡΡΡΠΊΠΈ Π΄ΠΎ 250 ΠΌΠ³/ΡΡΡΠΊΠΈ, ΠΎΡ 0,5 ΠΌΠ³/ΠΊΠ³/ΡΡΡΠΊΠΈ Π΄ΠΎ 6 ΠΌΠ³/ΠΊΠ³/ΡΡΡΠΊΠΈ (Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ ΡΠΎΡΡΠ°Π²Π»ΡΡ 3,6 ΠΌΠ³/ΠΊΠ³/ΡΡΡΠΊΠΈ). ΠΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΊΠ°ΠΊ Π² ΠΌΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠΌΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ, ΡΠ°ΠΊ ΠΈ Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Ρ Π°Π½ΡΠΈΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ Π΄ΡΡΠ³ΠΈΡ
Π³ΡΡΠΏΠΏ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΠΎΠ»Π½ΠΎΠ΅ ΠΊΡΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈΡΡΡΠΏΠΎΠ² Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΠΎ Ρ 8 ΠΈΠ· 31 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (26%), ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π²ΡΠΈΡ
ΡΠΎΠΏΠΈΡΠ°ΠΌΠ°Ρ ΠΈ Ρ 8 ΠΈΠ· 31 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (26%), ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π²ΡΠΈΡ
Π»Π°ΠΌΠΎΡΡΠΈΠ΄ΠΆΠΈΠ½. ΠΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° Π² Π²ΠΈΠ΄Π΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΡΠ°ΡΡΠΎΡΡ ΠΏΡΠΈΡΡΡΠΏΠΎΠ² Π½Π° 50 % ΠΈ Π±ΠΎΠ»Π΅Π΅ Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ Ρ 19 ΠΈΠ· 31 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (61%), ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π²ΡΠΈΡ
ΡΠΎΠΏΠΈΡΠ°ΠΌΠ°Ρ ΠΈ Ρ 14 ΠΈΠ· 31 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (45%), ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π²ΡΠΈΡ
Π»Π°ΠΌΠΎΡΡΠΈΠ΄ΠΆΠΈΠ½. Π£ 3 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΡΠ°ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈΡΡΡΠΏΠΎΠ² - Π² 3% ΡΠ»ΡΡΠ°Π΅Π² ΠΏΡΠΈ ΠΏΡΠΈΠ΅ΠΌΠ΅ ΡΠΎΠΏΠΈΡΠ°ΠΌΠ°ΡΠ° ΠΈ Π² 6% ΡΠ»ΡΡΠ°Π΅Π² ΠΏΡΠΈ ΠΏΡΠΈΠ΅ΠΌΠ΅ Π»Π°ΠΌΠΎΡΡΠΈΠ΄ΠΆΠΈΠ½Π°. ΠΡΠ²ΠΎΠ΄Ρ: ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ Π²ΡΡΠΎΠΊΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΎΠΏΠΈΡΠ°ΠΌΠ°ΡΠ° ΠΈ Π»Π°ΠΌΠΎΡΡΠΈΠ΄ΠΆΠΈΠ½Π° Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΠΎΠΊΠ°Π»ΡΠ½ΡΡ
ΡΠΎΡΠΌ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ
Rapid inactivation of airborne bacteria using atmospheric pressure dielectric barrier grating discharge
IEEE Transactions on Plasma Science, 35(5): pp. 1501-1510.Dielectric barrier discharge plasma has been known
to inactivate many different microorganisms on surfaces when
treatment times are on the order of seconds or minutes in duration.
In this paper, a unique plasma air cleaning facility was created
which combines a dielectric barrier grating discharge (DBGD)
with a filterless laboratory-scale ventilation system and is used
to treat concentrated bacterial bioaerosol in a moving air stream
at air flow rates of 25 L/s. Results indicate that plasma treatment
times on the order of milliseconds corresponding to one
pass through the DBGD device can achieve 1.5-log reduction in
culturable E. coli immediately after contact with plasma and 5-log
reduction totally following in the minutes after the plasma treatment.
A numerical characterization study was performed to help
predict and understand the mechanism of bacteria inactivation in
the DBD plasma from a variety of plasma factors
Rat visceral yolk sac cells: viability and expression of cell markers during maternal diabetes
Age-dependent response of murine female bone marrow cells to hyperbaric oxygen
Consequences of age on the effects of hyperbaric oxygen (HBO) on bone marrow (BM) derived stem cells and progenitors (SCPs) are largely unknown. We treated 2- and 18-month old C57BL/6 female mice by HBO. Hematopoietic stem cells and progenitors, enumerated as colony-forming units in culture, were doubled only in peripheral leukocytes and BM cells of young mice receiving HBO. In old mice colony-forming unit fibroblast numbers, a measure of mesenchymal stromal cells (MSCs) from BM, were high but unaffected by HBO. To further explore this finding, in BM-MSCs we quantified the transcripts of adipocyte early-differentiation genes peroxisome proliferator-activated receptor-Ξ³, CCAAT/enhancer binding protein-Ξ² and fatty-acid binding protein 4; these transcripts were not affected by age or HBO. However, osteoblast gene transcripts runt-related transcription factor 2, osterix (OSX) and alkaline phosphatase (AP) were twofold to 20-fold more abundant in MSCs from old control mice relative to those of young control mice. HBO affected expression of osteoblast markers only in old MSCs (OSX gene expression was reduced by twofold and AP expression was increased threefold). Our data demonstrate the impact of aging on the response of BM SCPs to HBO and indicate the potentially different age-related benefit of HBO in wound healing and tissue remodeling
Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial
Background: Oral semaglutide is the first oral glucagon-like peptide-1 (GLP-1) receptor agonist for glycaemic control in patients with type 2 diabetes. Type 2 diabetes is commonly associated with renal impairment, restricting treatment options. We aimed to investigate the efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment. Methods: This randomised, double-blind, phase 3a trial was undertaken at 88 sites in eight countries. Patients aged 18 years and older, with type 2 diabetes, an estimated glomerular filtration rate of 30β59 mL/min per 1Β·73 m2, and who had been receiving a stable dose of metformin or sulfonylurea, or both, or basal insulin with or without metformin for the past 90 days were eligible. Participants were randomly assigned (1:1) by use of an interactive web-response system, with stratification by glucose-lowering medication and renal function, to receive oral semaglutide (dose escalated to 14 mg once daily) or matching placebo for 26 weeks, in addition to background medication. Participants and site staff were masked to assignment. Two efficacy-related estimands were defined: treatment policy (regardless of treatment discontinuation or rescue medication) and trial product (on treatment without rescue medication) in all participants randomly assigned. Endpoints were change from baseline to week 26 in HbA1c (primary endpoint) and bodyweight (confirmatory secondary endpoint), assessed in all participants with sufficient data. Safety was assessed in all participants who received at least one dose of study drug. This trial is registered on ClinicalTrials.gov, number NCT02827708, and the European Clinical Trials Registry, number EudraCT 2015-005326-19, and is now complete. Findings: Between Sept 20, 2016, and Sept 29, 2017, of 721 patients screened, 324 were eligible and randomly assigned to oral semaglutide (n=163) or placebo (n=161). Mean age at baseline was 70 years (SD 8), and 168 (52%) of participants were female. 133 (82%) participants in the oral semaglutide group and 141 (88%) in the placebo group completed 26 weeks on treatment. At 26 weeks, oral semaglutide was superior to placebo in decreasing HbA1c (estimated mean change of β1Β·0 percentage point (SE 0Β·1; β11 mmol/mol [SE 0Β·8]) vs β0Β·2 percentage points (SE 0Β·1; β2 mmol/mol [SE 0Β·8]); estimated treatment difference [ETD]: β0Β·8 percentage points, 95% CI β1Β·0 to β0Β·6;
Representation of memory space by verbal collocation in the Russian media
Π ΡΡΠ°ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΡΡΡΡΡ Π³Π»Π°Π³ΠΎΠ»ΡΠ½ΡΠ΅ ΠΊΠΎΠ»Π»ΠΎΠΊΠ°ΡΠΈΠΈ ΠΏΠ°ΠΌΡΡΠΈ, ΡΠ΅Π°Π»ΠΈΠ·ΡΡΡΠΈΠ΅ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠ΄, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡΠΈΠΉ ΡΠΎΠ±ΠΎΠΉ Π½ΠΎΠΌΠΈΠ½Π°ΡΠΈΠΈ, Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠΎΡΠΎΡΡΡ
Π»Π΅ΠΆΠΈΡ ΠΎΡΠΎΠΆΠ΄Π΅ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΠ°ΠΌΡΡΠΈ Ρ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²ΠΎΠΌ, Π²ΠΌΠ΅ΡΡΠΈΠ»ΠΈΡΠ΅ΠΌ, Π³Π΄Π΅ ΠΈΠΌΠ΅Π΅Ρ ΠΌΠ΅ΡΡΠΎ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅, ΠΏΠ΅ΡΠ΅ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈΠ»ΠΈ ΠΏΡΠ΅Π±ΡΠ²Π°Π½ΠΈΠ΅ Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΈ ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΠΏΠ°ΠΌΡΡΠΈ. ΠΠ½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅ΠΌΡΠ΅ ΠΊΠΎΠ»Π»ΠΎΠΊΠ°ΡΠΈΠΈ ΠΏΠ°ΠΌΡΡΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΡΡΡ Π² ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΡ
Π‘ΠΠ ΠΏΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΈ ΡΡΠ°Π½ΡΠ»ΡΡΠΈΠΈ ΠΌΠ°ΡΡΠΎΠ²ΠΎΠΌΡ Π°Π΄ΡΠ΅ΡΠ°ΡΡ ΠΎΠ±ΡΠ°Π·Π° ΠΏΡΠΎΡΠ»ΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ ΠΊ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΠΌ ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ. ΠΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΏΠΎΠ»ΠΈΠ°ΡΠΏΠ΅ΠΊΡΠ½ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
Π΅Π΄ΠΈΠ½ΠΈΡΠ°Ρ
ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΡΠ΅ΠΏΡΠ΅Π·Π΅Π½ΡΠ°ΡΠΈΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ ΠΏΠ°ΠΌΡΡΠΈ Π² ΡΡΡΡΠΊΠΎΠΌ ΡΠ·ΡΠΊΠ΅.The paper presents the study of verbal collocations of the semantic field βMemoryβ, which actualize an identification of memory and some receptacle or space of movement, displacement, quiescence of memory operations object. Analyzed collocations are used in the Russian media to form and to transfer an image of the past to mass recipient, when fragments of collective memory are reproduced. The analysis methods allow to obtain different-type information about relevant units and to determine regularities of memory operations representation in the Russian language
- β¦