CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases:A Genome-wide Association Study Among Patients with Obstructive Uropathies

Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development. Objective: To identify genetic variants associated with kidney injury in patients with obstructive uropathy. Design, setting, and participants: We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase

Estimating Energy Efficiency Impacts Using Climate Wise "Wise Rules"

Climate Wise is an industrial energy efficiency program sponsored by the U.S. EPA, and supported by the U.S. DOE, working in partnership with more than 400 industrial companies, representing approximately than 11 percent of U.S. industrial energy use. Climate Wise provides technical assistance in the form of efficiency check-lists, handbooks, and one-on-one support through a toll-free Wise Line to help partners identify efficiency measures and quantify project impacts. Climate Wise has developed the Wise Rules for Industrial Efficiency (Wise Rules Tool Kit) to provide partners with ''Wise Rules" for estimating potential energy, cost, and greenhouse gas emissions savings from key industrial energy efficiency measures. The Tool Kit includes information on the following end-uses: boilers, steam systems, furnaces, process heating, waste heat recovery, cogeneration, compressed air systems, and process cooling. This paper provides an overview of the Wise Rules Tool Kit and presents excerpts from the document and sample Wise Rules

Climate Wise Boiler and Steam Efficiency Wise Rules

Climate Wise is an industrial energy efficiency program sponsored by the U.S. EPA, and supported by the U.S. DOE, working in partnership with more than 400 industrial companies. Many Climate Wise Partners are evaluating or implementing boiler and steam system efficiency measures and have requested assistance in quickly estimating the impacts of these projects through the Wise Line. Climate Wise has developed the Wise Rules for Industrial Efficiency (Wise Rules Tool Kit) to provide companies with simple rules of thumb, or Wise Rules, for estimating potential energy, cost, and greenhouse gas emissions savings from key industrial energy efficiency measures for a broad range of end uses, including boilers and steam systems. This paper presents excerpts from the Wise Rules Tool Kit on boiler and steam system efficiency measures

Comprehensive Approaches to Industrial Energy Efficiency: Examples from the Climate Wise Program

The Climate Wise Program is a partnership initiative sponsored by the U.S. EPA, with technical support from the U.S. DOE, with industry. It is designed to stimulate the voluntary reduction of greenhouse gas emissions among participating manufacturing companies. Since its inception in 1994, more than 400, companies representing approximately 11 percent of U.S. industrial energy use have joined the program. In doing so, these companies agreed to develop a portfolio of cost-effective and innovative actions and, in turn, receive technical assistance, peer exchange opportunities, and help in identifying financial assistance resources. This paper presents an overview and analysis of the Action Plans received to date and spotlights the comprehensive approaches that several partner companies are taking

Comprehensive Approaches to Industrial Energy Efficiency: Examples from the Climate Wise Program

The Climate Wise Program is a partnership initiative sponsored by the U.S. EPA, with technical support from the U.S. DOE, with industry. It is designed to stimulate the voluntary reduction of greenhouse gas emissions among participating manufacturing companies. Since its inception in 1994, more than 400, companies representing approximately 11 percent of U.S. industrial energy use have joined the program. In doing so, these companies agreed to develop a portfolio of cost-effective and innovative actions and, in turn, receive technical assistance, peer exchange opportunities, and help in identifying financial assistance resources. This paper presents an overview and analysis of the Action Plans received to date and spotlights the comprehensive approaches that several partner companies are taking

Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ. We performed three-dimensional imaging to characterize lymphatic vessel formation in the mammalian embryonic kidney at single-cell resolution. In mouse, we visually and quantitatively assessed the development of kidney lymphatic vessels, remodeling from a ring-like anastomosis under the nascent renal pelvis, a site of VEGF-C expression, to form a patent vascular plexus. We identified a heterogenous population of lymphatic endothelial cell clusters in mouse and human embryonic kidneys. Exogenous VEGF-C expanded the lymphatic population in explanted mouse embryonic kidneys. Finally, we characterized complex kidney lymphatic abnormalities in a genetic mouse model of polycystic kidney disease. Our study provides novel insights into the development of kidney lymphatic vasculature; a system which likely has fundamental roles in renal development, physiology and disease