Radiative effects on false vacuum decay in Higgs-Yukawa theory

We derive fermionic Green’s functions in the background of the Euclidean solitons describing false vacuum decay in a prototypal Higgs-Yukawa theory. In combination with appropriate counterterms for the masses, couplings and wave-function normalization, these can be used to calculate radiative corrections to the soliton solutions and transition rates that fully account for the inhomogeneous background provided by the nucleated bubble. We apply this approach to the archetypal example of transitions between the quasidegenerate vacua of a massive scalar field with a quartic self-interaction. The effect of fermion loops is compared with those from additional scalar fields, and the loop effects accounting for the spacetime inhomogeneity of the tunneling configuration are compared with those where gradients are neglected. We find that scalar loops lead to an enhancement of the decay rate, whereas fermion loops lead to a suppression. These effects get relatively amplified by a perturbatively small factor when gradients are accounted for. In addition, we observe that the radiative corrections to the solitonic field profiles are smoother when the gradients are included. The method presented here for computing fermionic radiative corrections should be applicable beyond the archetypal example of vacuum decay. In particular, we work out methods that are suitable for calculations in the thin-wall limit, as well as others that take account of the full spherical symmetry of the solution. For the latter case, we construct the Green’s functions based on spin hyperspherical harmonics, which are eigenfunctions of the appropriate angular momentum operators that commute with the Dirac operator in the solitonic background

Progress in gene therapy for neurological disorders

Diseases of the nervous system have devastating effects and are widely distributed among the population, being especially prevalent in the elderly. These diseases are often caused by inherited genetic mutations that result in abnormal nervous system development, neurodegeneration, or impaired neuronal function. Other causes of neurological diseases include genetic and epigenetic changes induced by environmental insults, injury, disease-related events or inflammatory processes. Standard medical and surgical practice has not proved effective in curing or treating these diseases, and appropriate pharmaceuticals do not exist or are insufficient to slow disease progression. Gene therapy is emerging as a powerful approach with potential to treat and even cure some of the most common diseases of the nervous system. Gene therapy for neurological diseases has been made possible through progress in understanding the underlying disease mechanisms, particularly those involving sensory neurons, and also by improvement of gene vector design, therapeutic gene selection, and methods of delivery. Progress in the field has renewed our optimism for gene therapy as a treatment modality that can be used by neurologists, ophthalmologists and neurosurgeons. In this Review, we describe the promising gene therapy strategies that have the potential to treat patients with neurological diseases and discuss prospects for future development of gene therapy

A conceptual framework for outsourcing of materials handling activities in automotive:differentiation and implementation

This article discusses the outsourcing of materials handling activities and investigates different options for its implementation. The article uses descriptive case studies found in literature from the Western European automotive industry to map out differences in current practice and to evaluate frameworks found in the literature. These frameworks appear to be limited to decision making at a strategic level. In addition, they only allow decisions relating to the outsourcing of the logistics function in general, not of materials handling in particular. Based on this study and other descriptions of materials handling practice in the literature, a new conceptual framework for outsourcing of materials handling is proposed, which facilitates decision making at a tactical/operational level. The functionality of the framework is tested in a series of cases at a major production and logistics facility of Scania