35,909 research outputs found
Photoemission Evidence for a Remnant Fermi Surface and d-Wave-Like Dispersion in Insulating Ca2CuO2Cl2
An angle resolved photoemission study on Ca2CuO2Cl2, a parent compound of
high Tc superconductors is reported. Analysis of the electron occupation
probability, n(k) from the spectra shows a steep drop in spectral intensity
across a contour that is close to the Fermi surface predicted by the band
calculation. This analysis reveals a Fermi surface remnant even though
Ca2CuO2Cl2 is a Mott insulator. The lowest energy peak exhibits a dispersion
with approximately the |cos(kxa)-cos(kya)| form along this remnant Fermi
surface. Together with the data from Dy doped Bi2Sr2CaCu2O(8 + delta) these
results suggest that this d-wave like dispersion of the insulator is the
underlying reason for the pseudo gap in the underdoped regime.Comment: 9 pages, including 7 figures. Published in Science, one figure
correcte
Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities.
BackgroundThe phosphatidylinositol 3-kinase (PI3K) pathway is frequently altered in cancer. This report describes the landscape of PI3K alterations in solid tumors as well as co-alterations serving as potential resistance/attenuation mechanisms.MethodsConsecutive samples were analyzed in a commercial Clinical Laboratory Improvement Amendment-certified laboratory using comprehensive genomic profiling performed by next-generation sequencing (315 genes). The co-alterations evaluated included the Erb-B2 receptor tyrosine kinase 2 (ERBB2), ERBB3, ERBB4, RAS, MET proto-oncogene tyrosine kinase (MET), and mitogen-activated protein kinase kinase (MAP2K) genes as well as tumor protein 53 (TP53), estrogen receptor 1 (ESR1), and androgen receptor (AR).ResultsAlterations in any of 18 PI3K-pathway associated genes were identified in 44% of 60,991 tumors. Although single base and insertions/deletions (indels) were the most frequent alterations, copy number changes and rearrangements were identified in 11% and 0.9% of patients, respectively. Overall, the most frequently altered genes were PIK3 catalytic subunit α (PIK3CA) (13%), phosphatase and tensin homolog (PTEN) (9%), and serine/threonine kinase 11 (STK11) (5%). Tumor types that frequently harbored at least 1 PI3K alteration were uterine (77%), cervical (62%), anal (59%), and breast (58%) cancers. Alterations also were discerned frequently in tumors with carcinosarcoma (89%) and squamous cell carcinoma (62%) histologies. Tumors with a greater likelihood of co-occurring PI3K pathway and MAPK pathway alterations included colorectal cancers (odds ratio [OR], 1.64; P < .001), mesotheliomas (OR, 2.67; P = .024), anal cancers (OR, 1.98; P = .03), and nonsquamous head and neck cancers (OR, 2.03; P = .019). The co-occurrence of ESR1 and/or AR alterations with PI3K alterations was statistically significant in bladder, colorectal, uterine, prostate, and unknown primary cancers.ConclusionsComprehensive genomic profiling reveals altered PI3K-related genes in 44% of solid malignancies, including rare disease and histology types. The frequency of alterations and the co-occurrence of resistance pathways vary by tumor type, directly affecting opportunities for targeted therapy
Anomalous high energy dispersion in photoemission spectra from insulating cuprates
Angle resolved photoelectron spectroscopic measurements have been performed
on an insulating cuprate Ca_2CuO_2Cl_2. High resolution data taken along the
\Gamma to (pi,pi) cut show an additional dispersive feature that merges with
the known dispersion of the lowest binding energy feature, which follows the
usual strongly renormalized dispersion of ~0.35 eV. This higher energy part
reveals a dispersion that is very close to the unrenormalized band predicted by
band theory. A transfer of spectral weight from the low energy feature to the
high energy feature is observed as the \Gamma point is approached. By comparing
with theoretical calculations the high energy feature observed here
demonstrates that the incoherent portion of the spectral function has
significant structure in momentum space due to the presence of various energy
scales.Comment: 5 pages, 3 figure
Sum Rule Description of Color Transparency
The assumption that a small point-like configuration does not interact with
nucleons leads to a new set of sum rules that are interpreted as models of the
baryon-nucleon interaction. These models are rendered semi-realistic by
requiring consistency with data for cross section fluctuations in proton-proton
diffractive collisions.Comment: 22 pages + 3 postscript figures attache
From Physical to Cyber: Escalating Protection for Personalized Auto Insurance
Nowadays, auto insurance companies set personalized insurance rate based on
data gathered directly from their customers' cars. In this paper, we show such
a personalized insurance mechanism -- wildly adopted by many auto insurance
companies -- is vulnerable to exploit. In particular, we demonstrate that an
adversary can leverage off-the-shelf hardware to manipulate the data to the
device that collects drivers' habits for insurance rate customization and
obtain a fraudulent insurance discount. In response to this type of attack, we
also propose a defense mechanism that escalates the protection for insurers'
data collection. The main idea of this mechanism is to augment the insurer's
data collection device with the ability to gather unforgeable data acquired
from the physical world, and then leverage these data to identify manipulated
data points. Our defense mechanism leveraged a statistical model built on
unmanipulated data and is robust to manipulation methods that are not foreseen
previously. We have implemented this defense mechanism as a proof-of-concept
prototype and tested its effectiveness in the real world. Our evaluation shows
that our defense mechanism exhibits a false positive rate of 0.032 and a false
negative rate of 0.013.Comment: Appeared in Sensys 201
Multiple-Scattering Series For Color Transparency
Color transparency CT depends on the formation of a wavepacket of small
spatial extent. It is useful to interpret experimental searches for CT with a
multiple scattering scattering series based on wavepacket-nucleon scattering
instead of the standard one using nucleon-nucleon scattering. We develop
several new techniques which are valid for differing ranges of energy. These
techniques are applied to verify some early approximations; study new forms of
the wave-packet-nucleon interaction; examine effects of treating wave packets
of non-zero size; and predict the production of 's in electron scattering
experiments.Comment: 26 pages, U.Wa. preprint 40427-23-N9
Spectra of sparse non-Hermitian random matrices: an analytical solution
We present the exact analytical expression for the spectrum of a sparse
non-Hermitian random matrix ensemble, generalizing two classical results in
random-matrix theory: this analytical expression forms a non-Hermitian version
of the Kesten-Mckay law as well as a sparse realization of Girko's elliptic
law. Our exact result opens new perspectives in the study of several physical
problems modelled on sparse random graphs. In this context, we show
analytically that the convergence rate of a transport process on a very sparse
graph depends upon the degree of symmetry of the edges in a non-monotonous way.Comment: 5 pages, 5 figures, 12 pages supplemental materia
On separable Fokker-Planck equations with a constant diagonal diffusion matrix
We classify (1+3)-dimensional Fokker-Planck equations with a constant
diagonal diffusion matrix that are solvable by the method of separation of
variables. As a result, we get possible forms of the drift coefficients
providing separability of the
corresponding Fokker-Planck equations and carry out variable separation in the
latter. It is established, in particular, that the necessary condition for the
Fokker-Planck equation to be separable is that the drift coefficients must be linear. We also find the necessary condition for
R-separability of the Fokker-Planck equation. Furthermore, exact solutions of
the Fokker-Planck equation with separated variables are constructedComment: 20 pages, LaTe
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