810 research outputs found
A New Approach to Background Subtraction in Low-Energy Neutrino Experiments
We discuss a new method to extract neutrino signals in low energy
experiments. In this scheme the symmetric nature of most backgrounds allows for
direct cancellation from data. The application of this technique to the Palo
Verde reactor neutrino oscillation experiment allowed us to reduce the
measurement errors on the anti-neutrino flux from % to %. We
expect this method to substantially improve the data quality in future low
background experiments such as KamLAND and LENS.Comment: 7 pages, 2 figure
Tundra photosynthesis captured by satellite-observed solar-induced chlorophyll fluorescence
Accurately quantifying the timing and magnitude of respiration and photosynthesis by high‐latitude ecosystems is important for understanding how a warming climate influences global carbon cycling. Data‐driven estimates of photosynthesis across Arctic regions often rely on satellite‐derived enhanced vegetation index (EVI); we find that satellite observations of solar‐induced chlorophyll fluorescence (SIF) provide a more direct proxy for photosynthesis. We model Alaskan tundra CO2 cycling (2012–2014) according to temperature and shortwave radiation and alternately input EVI or SIF to prescribe the annual seasonal cycle of photosynthesis. We find that EVI‐based seasonality indicates spring “green‐up” to occur 9 days prior to SIF‐based estimates, and that SIF‐based estimates agree with aircraft and tower measurements of CO2. Adopting SIF, instead of EVI, for modeling the seasonal cycle of tundra photosynthesis can result in more accurate estimates of growing season duration and net carbon uptake by arctic vegetation
Origin of Life
The evolution of life has been a big enigma despite rapid advancements in the
fields of biochemistry, astrobiology, and astrophysics in recent years. The
answer to this puzzle has been as mind-boggling as the riddle relating to
evolution of Universe itself. Despite the fact that panspermia has gained
considerable support as a viable explanation for origin of life on the Earth
and elsewhere in the Universe, the issue remains far from a tangible solution.
This paper examines the various prevailing hypotheses regarding origin of life
like abiogenesis, RNA World, Iron-sulphur World, and panspermia; and concludes
that delivery of life-bearing organic molecules by the comets in the early
epoch of the Earth alone possibly was not responsible for kick-starting the
process of evolution of life on our planet.Comment: 32 pages, 8 figures,invited review article, minor additio
A computational analysis of lower bounds for big bucket production planning problems
In this paper, we analyze a variety of approaches to obtain lower bounds for multi-level production planning problems with big bucket capacities, i.e., problems in which multiple items compete for the same resources. We give an extensive survey of both known and new methods, and also establish relationships between some of these methods that, to our knowledge, have not been presented before. As will be highlighted, understanding the substructures of difficult problems provide crucial insights on why these problems are hard to solve, and this is addressed by a thorough analysis in the paper. We conclude with computational results on a variety of widely used test sets, and a discussion of future research
Donor states in modulation-doped Si/SiGe heterostructures
We present a unified approach for calculating the properties of shallow
donors inside or outside heterostructure quantum wells. The method allows us to
obtain not only the binding energies of all localized states of any symmetry,
but also the energy width of the resonant states which may appear when a
localized state becomes degenerate with the continuous quantum well subbands.
The approach is non-variational, and we are therefore also able to evaluate the
wave functions. This is used to calculate the optical absorption spectrum,
which is strongly non-isotropic due to the selection rules. The results
obtained from calculations for Si/SiGe quantum wells allow us to
present the general behavior of the impurity states, as the donor position is
varied from the center of the well to deep inside the barrier. The influence on
the donor ground state from both the central-cell effect and the strain arising
from the lattice mismatch is carefully considered.Comment: 17 pages, 10 figure
Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability
There are no biological treatments for fetal alcohol spectrum disorders (FASDs), lifelong conditions associated with physical anomalies, brain damage, and neurocognitive abnormalities. In preclinical studies, choline partially ameliorates memory and learning deficits from prenatal alcohol exposure. This phase I pilot study evaluated the feasibility, tolerability, and potential adverse effects of choline supplementation in children with FASD. We hypothesized that choline would be well tolerated with minimal adverse events. The study design was a double-blind, randomized, placebo-controlled trial. Participants included 20 children aged 2.5 to 4.9 years with prenatal alcohol exposure and FASD diagnoses. Participants were randomly assigned to 500 mg choline or placebo daily for 9 months (10 active, 10 placebo). Primary outcome measures included feasibility, tolerability, adverse effects, and serum choline levels. Seventeen participants completed the study. Compliance was 82% to 87%, as evidenced by parent-completed log sheets and dose counts. Periodic 24-hour dietary recalls showed no evidence of dietary confounding. Adverse events were minimal and were equivalent in the active and placebo arms with the exception of fishy body odor, which occurred only in the active group. There were no serious adverse events to research participants. This phase I pilot study demonstrates that choline supplementation at 500 mg/d for 9 months in children aged 2 to 5 years is feasible and has high tolerability. Further examination of the efficacy of choline supplementation in FASD is currently underway
Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder
Background: Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits. FASD is often conceptualized as static and permanent, but interventions that capitalize on brain plasticity and critical developmental windows are emerging. We present a long-term follow-up study evaluating the neurodevelopmental effects of choline supplementation in children with FASD 4 years after an initial efficacy trial. Methods: The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2-5-year-olds with FASD. Participants include 31 children (16 placebo; 15 choline) seen 4 years after trial completion. The mean age at follow-up was 8.6 years. Diagnoses were 12.9% fetal alcohol syndrome (FAS), 41.9% partial FAS, and 45.1% alcohol-related neurodevelopmental disorder. The follow-up included measures of intelligence, memory, executive functioning, and behavior. Results: Children who received choline had higher non-verbal intelligence, higher visual-spatial skill, higher working memory ability, better verbal memory, and fewer behavioral symptoms of attention deficit hyperactivity disorder than the placebo group. No differences were seen for verbal intelligence, visual memory, or other executive functions. Conclusions: These data support choline as a potential neurodevelopmental intervention for FASD and highlight the need for long-term follow-up to capture treatment effects on neurodevelopmental trajectories. Trial registration: ClinicalTrials.Gov #NCT01149538; Registered: June 23, 2010; first enrollment July 2, 2010
Functional and genetic analysis of regulatory regions of coliphage H-19B: location of shiga-like toxin and lysis genes suggest a role for phage functions in toxin release
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74784/1/j.1365-2958.1998.00890.x.pd
Prevalence and in vitro susceptibility of methicillin-resistant Staphylococcus pseudintermedius (MRSP) from skin and nostrils of dogs with superficial pyoderma
- …