2,037 research outputs found
Synthesis and C−C Coupling Reactivity of a Dinuclear Ni^I−Ni^I Complex Supported by a Terphenyl Diphosphine
Mono- and bimetallic complexes of nickel supported by a terphenyl diphosphine have been synthesized. The reported complexes show diverse metal−arene interactions in the solid state. Reactions of an o,o′-biphenyldiyl dinickel complex with CO and dichloroalkanes lead to fluorene derivatives, indicating the formation of carbon−carbon bonds at a bimetallic moiety
Facilitators and Barriers to Prescribing PreExposure Prophylaxis (PrEP) for the Prevention of HIV
Background:
What is PrEP and who gets it?
PrEP is the use of medication by individuals to prevent HIV contraction, approved in 2012 after demonstrating safety and efficacy in the iPrEx study and Partners PrEP2 trials.
HIV infection risk is 92% lower in patients using PrEP.
Truvada®, a combination of tenofovir and emtricitabine taken orally daily, is the only approved PrEP regimen and is intended to compliment other prevention strategies such as condoms.
HIV negative-individuals at risk for exposure to HIV have been identified as men who have sex with men (MSM), IV drug users, heterosexuals who have unprotected sex with partners of unknown HIV status, and those in serodiscordant relationships.
Barriers to PrEP Implementation
PrEP is effective when patients adhere; however, both the medical community and some high-risk populations have been slow to adopt it as an HIV prevention strategy.
Surveys have shown clinicians perceived barriers to PrEP such as adverse side effects, viral drug resistance, increased high-risk behavior, cost, and training.
HIV in Vermont
New diagnoses of HIV among Vermont residents has remained relatively stable over the last twenty years.
Vermont CARES, a non-profit, offers free and anonymous HIV tests and in-person risk-reduction counseling. Clients are increasingly asking about PrEP as a prevention strategy, but the response from the medical community is difficult to ascertain.https://scholarworks.uvm.edu/comphp_gallery/1235/thumbnail.jp
Overrepresented and Under Discussed: From Conceptual Analysis to Practical Implications for Crossover among Black Girls
Crossover youth are young people who have experiences of maltreatment and exhibit delinquency, which may or may not come to the formal attention of the child welfare and juvenile justice systems. Black youth are overrepresented among the crossover youth population, and evidence suggests that Black girls who experience crossover are particularly in need of specialized attention. Black girls’ experiences within child welfare, juvenile justice, and related systems are unique given the intersection of race and gender in light of issues such as discrimination, disparate treatment, and abuse undergone while in the care of agencies touted to protect them. Guided by a Black Feminism perspective and Critical Race Theory that acknowledge the intersection of race, gender, and additional social identities as well as structural racism and power, this manuscript provides an overview of the aforementioned issues and focuses on practical implications for better serving Black girls who experience crossover and their mental health. The authors offer a strengths-based, community framework to better understand the mental health needs of Black girls who experience maltreatment and exhibit delinquent behavior. In particular, the aim is to recognize the role that systemic racism and gendered experiences and obstacles have on individuals navigating the child welfare and juvenile justice systems. Finally, the authors present tangible implications for individuals and communities that are unique to the intersectional needs of Black system-involved girls
Axon fasciculation in the developing olfactory nerve
Olfactory sensory neuron (OSN) axons exit the olfactory epithelium (OE) and extend toward the olfactory bulb (OB) where they coalesce into glomeruli. Each OSN expresses only 1 of approximately 1,200 odor receptors (ORs). OSNs expressing the same OR are distributed in restricted zones of the OE. However, within a zone, the OSNs expressing a specific OR are not contiguous - distribution appears stochastic. Upon reaching the OB the OSN axons expressing the same OR reproducibly coalesce into two to three glomeruli. While ORs appear necessary for appropriate convergence of axons, a variety of adhesion associated molecules and activity-dependent mechanisms are also implicated. Recent data suggest pre-target OSN axon sorting may influence glomerular convergence. Here, using regional and OR-specific markers, we addressed the spatio-temporal properties associated with the onset of homotypic fasciculation in embryonic mice and assessed the degree to which subpopulations of axons remain segregated as they extend toward the nascent OB. We show that immediately upon crossing the basal lamina, axons uniformly turn sharply, usually at an approximately 90° angle toward the OB. Molecularly defined subpopulations of axons show evidence of spatial segregation within the nascent nerve by embryonic day 12, within 48 hours of the first OSN axons crossing the basal lamina, but at least 72 hours before synapse formation in the developing OB. Homotypic fasciculation of OSN axons expressing the same OR appears to be a hierarchical process. While regional segregation occurs in the mesenchyme, the final convergence of OR-specific subpopulations does not occur until the axons reach the inner nerve layer of the OB
Fluoride occurrence in the lower East African Rift System, Southern Malawi
Countries located on the East African Rift System (EARS) are vulnerable to fluoride in their groundwater; a vulnerability for the developing country of Malawi at the southern rift periphery that is not well characterised. Groundwater fluoride occurrence in Malawi is documented here to better understand and manage fluoride risks posed. Available literature and Gov't of Malawi archive fluoride data spanning some fifty years have been collated and augmented by our own 2016–18 surveys of groundwater quality in Southern Malawi, targeting deep-sourced springs. In total, fluoride data for 1365 borehole, spring and hot spring samples were assembled. Statistically, 83% of samples were below the 1.5 mg/l WHO limit, concentrations in the 1.5–6 mg/l range between former (pre-1993) and current WHO guidelines at 14%, and those with fluoride above the current Malawi (former WHO) 6 mg/l guideline, at 3%. A lower occurrence than in other zones of the EARS, but indicative of a need for a Malawi Gov't management policy revision and associated management strategies endorsed by several documented incidences of dental fluorosis in proximity to high fluoride groundwater. Increased fluoride is related to increased groundwater temperatures signifying the importance of geothermal groundwater provenance. Temperature data may indeed be used as a proxy indicator of fluoride risk; samples with a temperature >32 °C, contained >6 mg/l fluoride. Structural geological controls appear to allow deep geothermal groundwaters to come to the near surface, as evidenced by increased fluoride in springs and boreholes close to faulted areas. Hydrochemical evaluation shows that fluoride concentrations are influenced by fluorite equilibration and sensitivity to calcium and pH. Recommendations are made to further document the occurrence of fluoride and enhance management of risks due to fluoride in drinking water in Malawi. With fluoride as a key indicator within Sustainable Development Goal number 6, the current Malawi standard and waters with concentration between 1.5 and 6 mg/l will come under increased scrutiny and pose a key challenge to assessment and management efforts
Proton transfer and esterification reactions in EMIMOAc-based acidic ionic liquids
Acetate-based ionic liquids (such as 1-ethyl-3-methylimidazolium acetate, EMIMOAc) have potential applications for CO2 absorption and electrochemical reduction, chemical separations and extractions, and Fischer esterification of alcohols, amines, and starch. Both strong and weak organic acids can be dissolved in EMIMOAc and yield interesting proton-rich acidic ionic liquid solutions. We have used GCMS vapor pressure measurements, spectroscopic methods, calorimetry, and viscosity/conductivity measurements to investigate the properties and reactions of various acids dissolved in EMIMOAc. Unique proton transfer and esterification reactions are observed in many of these acidic solutions with carboxylic acids or sulfonic acids as solutes. Some acids react with the acetate anion to produce acetic acid, which provides a measure of acid strength in ionic liquid solvents. In addition, we observed an esterification reaction that might involve the imidazolium cation and the acetate anion to yield methyl acetate
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Chronic Stress in Vocational and Intimate Partner Domains as Predictors of Depressive Symptoms After Breast Cancer Diagnosis.
BackgroundAfter cancer diagnosis, depressive symptoms are elevated on average and decline over time, but substantial variability is apparent. Few studies have examined to what extent chronic stress in distinct life domains affects depressive symptoms.PurposeChronic stress in vocational and intimate partner life domains, and their interaction, were tested as predictors of depressive symptoms after breast cancer diagnosis.MethodsWomen (N = 460) completed validated interviews regarding chronic stress in specific life domains shortly after diagnosis and a measure of depressive symptoms every 6 weeks for 6 months.ResultsIn latent growth curve modeling analyses, greater chronic stress in work (b = 2.90; p < .001) and intimate partner domains (b = 1.38, p = .02) was associated with higher depressive symptoms at study entry (intercept), and greater work stress predicted faster recovery from depressive symptoms over time (b = -0.10; p = .01). The two domains of chronic stress also interacted significantly on depressive symptoms at study entry (b = -1.54; p < .02) and over time (b = 0.14; p < .001). Greater work stress was associated with higher depressive symptoms at study entry regardless of intimate partner stress, but greater intimate partner stress was associated with higher depressive symptoms when work stress was low. The decline over 6 months in initially elevated depressive symptoms predicted by high work stress was significantly steeper when intimate partner stress was low.ConclusionsTargeting interventions to recently diagnosed breast cancer patients living with chronically stressful vocational and intimate partner life circumstances could be worthwhile
Neuroleptanalgesia for acute abdominal pain: a systematic review
Background: Acute abdominal pain (AAP) comprises up to 10% of all emergency department (ED) visits. Current pain management practice is moving toward multi-modal analgesia
regimens that decrease opioid use.
Objective: This project sought to determine whether, in patients with AAP (population), does
administration of butyrophenone antipsychotics (intervention) compared to placebo, usual care,
or opiates alone (comparisons) improve analgesia or decrease opiate consumption (outcomes)?
Methods: A structured search was performed in Cochrane CENTRAL, CINAHL, Database of
Abstracts of Reviews of Effects, Directory of Open Access Journals, Embase, IEEE-Xplorer,
Latin American and Caribbean Health Sciences Literature, Magiran, PubMed, Scientific Information Database, Scopus, TÃœBÄ°TAK ULAKBÄ°M, and Web of Science. Clinical trial registries
(ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform,
and Australian New Zealand Clinical Trials Registry), relevant bibliographies, and conference
proceedings were also searched. Searches were not limited by date, language, or publication
status. Studies eligible for inclusion were prospective randomized clinical trials enrolling
patients (age ≥18 years) with AAP treated in acute care environments (ED, intensive care unit,
postoperative). The butyrophenone must have been administered either intravenously or intramuscularly. Comparison groups included placebo, opiate only, corticosteroids, non-steroidal
anti-inflammatory drugs, or acetaminophen.
Results: We identified 7,217 references. Six studies met inclusion criteria. One study assessed
ED patients with AAP associated with gastroparesis, whereas five studies assessed patients with
postoperative AAP: abdominal hysterectomy (n=4), sleeve gastrectomy (n=1). Three of four studies
found improvements in pain intensity with butyrophenone use. Three of five studies reported no
change in postoperative opiate consumption, while two reported a decrease. One ED study reported
no change in patient satisfaction, while one postoperative study reported improved satisfaction
scores. Both extrapyramidal side effects (n=3) and sedation (n=3) were reported as unchanged.
Conclusion: Based on available evidence, we cannot draw a conclusion on the efficacy or
benefit of neuroleptanalgesia in the management of patients with AAP. However, preliminary
data suggest that it may improve analgesia and decrease opiate consumption
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