4,570 research outputs found
Low loss Ge-on-Si waveguides operating in the 8â14 ”m atmospheric transmission window
Germanium-on-silicon waveguides were modeled, fabricated and characterized at wavelengths ranging from 7.5 to 11 ”m. Measured waveguide losses are below 5 dB/cm for both TE and TM polarization and reach values of ⌠1 dB/cm for ℠10 ”m wavelengths for the TE polarization. This work demonstrates experimentally for the first time that Ge-on-Si is a viable waveguide platform for sensing in the molecular fingerprint spectral region. Detailed modeling and analysis is presented to identify the various loss contributions, showing that with practical techniques losses below 1 dB/cm could be achieved across the full measurement range
The fundamental problem of command : plan and compliance in a partially centralised economy
When a principal gives an order to an agent and advances resources for its implementation, the temptations for the agent to shirk or steal from the principal rather than comply constitute the fundamental problem of command. Historically, partially centralised command economies enforced compliance in various ways, assisted by nesting the fundamental problem of exchange within that of command. The Soviet economy provides some relevant data. The Soviet command system combined several enforcement mechanisms in an equilibrium that shifted as agents learned and each mechanism's comparative costs and benefits changed. When the conditions for an equilibrium disappeared, the system collapsed.Comparative Economic Studies (2005) 47, 296â314. doi:10.1057/palgrave.ces.810011
Fine structure in the gamma-ray sky
The EGRET results for gamma-ray intensities in and near the Galactic Plane
have been analysed in some detail. Attention has been concentrated on energies
above 1 GeV and the individual intensities in a longitude bin have
been determined and compared with the large scale mean found from a nine-degree
polynomial fit.
Comparison has been made of the observed standard deviation for the ratio of
these intensities with that expected from variants of our model. The basic
model adopts cosmic ray origin from supernova remnants, the particles then
diffusing through the Galaxy with our usual 'anomalous diffusion'. The variants
involve the clustering of SN, a frequency distribution for supernova explosion
energies, and 'normal', rather than 'anomalous' diffusion.
It is found that for supernovae of unique energy, and our usual anomalous
diffusion, clustering is necessary, particularly in the Inner Galaxy. An
alternative, and preferred, situation is to adopt the model with a frequency
distribution of supernova energies. The results for the Outer Galaxy are such
that no clustering is required.Comment: 10 pages, 4 figures, 1 table, accepted for publication in J.Phys.G:
Nucl.Part.Phy
Modeling potential responses to smallpox as a bioterrorist weapon.
We constructed a mathematical model to describe the spread of smallpox after a deliberate release of the virus. Assuming 100 persons initially infected and 3 persons infected per infectious person, quarantine alone could stop disease transmission but would require a minimum daily removal rate of 50% of those with overt symptoms. Vaccination would stop the outbreak within 365 days after release only if disease transmission were reduced to <0.85 persons infected per infectious person. A combined vaccination and quarantine campaign could stop an outbreak if a daily quarantine rate of 25% were achieved and vaccination reduced smallpox transmission by > or = 33%. In such a scenario, approximately 4,200 cases would occur and 365 days would be needed to stop the outbreak. Historical data indicate that a median of 2,155 smallpox vaccine doses per case were given to stop outbreaks, implying that a stockpile of 40 million doses should be adequate
A new class of semiclassical wave function uniformizations
We present a new semiclassical technique which relies on replacing
complicated classical manifold structure with simpler manifolds, which are then
evaluated by the usual semiclassical rules. Under circumstances where the
original manifold structure gives poor or useless results semiclassically the
replacement manifolds can yield remarkable accuracy. We give several working
examples to illustrate the theory presented here.Comment: 12 pages (incl. 12 figures
Cloning of a gene encoding an antigen associated with the centrosome in Drosophila
The monoclonal antibody Bx63 recognizes a centrosomal antigen of Drosophila melanogaster by indirect immunofluorescence and identifies two proteins, with apparent molecular weights of 185 x 10³ and 66 x 10³, on Western blots. We have used this antibody to isolate five clones (λcs1, -2, -3, -4 and λj63) from λgt11 expression libraries of Drosophila DNA. Using polyclonal anti-centrosomal sera raised against both immunoaffinity-purified Bx63 antigen and electrophoretically purified fusion protein from clone λcs3, we have demonstrated that the fusion proteins encoded by four of these clones (λcs1-4) share at least two epitopes with the 185 x 10³ M_r centrosomal antigen. This indicates that clones λcs1-4 contain DNA from the gene coding for this protein. The four clones are independent isolates from a single chromosomal site, which we show by in situ hybridization to correspond with salivary gland chromosome region 88E 4-8. A low-abundance transcript of approximately 4.0 x 10³ bases corresponding to the cloned gene is detected in all stages of the Drosophila life-cycle
Cloning of a gene encoding an antigen associated with the centrosome in Drosophila
The monoclonal antibody Bx63 recognizes a centrosomal antigen of Drosophila melanogaster by indirect immunofluorescence and identifies two proteins, with apparent molecular weights of 185 x 10³ and 66 x 10³, on Western blots. We have used this antibody to isolate five clones (λcs1, -2, -3, -4 and λj63) from λgt11 expression libraries of Drosophila DNA. Using polyclonal anti-centrosomal sera raised against both immunoaffinity-purified Bx63 antigen and electrophoretically purified fusion protein from clone λcs3, we have demonstrated that the fusion proteins encoded by four of these clones (λcs1-4) share at least two epitopes with the 185 x 10³ M_r centrosomal antigen. This indicates that clones λcs1-4 contain DNA from the gene coding for this protein. The four clones are independent isolates from a single chromosomal site, which we show by in situ hybridization to correspond with salivary gland chromosome region 88E 4-8. A low-abundance transcript of approximately 4.0 x 10³ bases corresponding to the cloned gene is detected in all stages of the Drosophila life-cycle
Slow-light optical bullets in arrays of nonlinear Bragg-grating waveguides
We demonstrate how to control independently both spatial and temporal
dynamics of slow light. We reveal that specially designed nonlinear waveguide
arrays with phase-shifted Bragg gratings demonstrate the frequency-independent
spatial diffraction near the edge of the photonic bandgap, where the group
velocity of light can be strongly reduced. We show in numerical simulations
that such structures allow a great flexibility in designing and controlling
dispersion characteristics, and open a way for efficient spatiotemporal
self-trapping and the formation of slow-light optical bullets.Comment: 4 pages, 4 figures; available from
http://link.aps.org/abstract/PRL/v97/e23390
Universal Scaling of Optimal Current Distribution in Transportation Networks
Transportation networks are inevitably selected with reference to their
global cost which depends on the strengths and the distribution of the embedded
currents. We prove that optimal current distributions for a uniformly injected
d-dimensional network exhibit robust scale-invariance properties, independently
of the particular cost function considered, as long as it is convex. We find
that, in the limit of large currents, the distribution decays as a power law
with an exponent equal to (2d-1)/(d-1). The current distribution can be exactly
calculated in d=2 for all values of the current. Numerical simulations further
suggest that the scaling properties remain unchanged for both random injections
and by randomizing the convex cost functions.Comment: 5 pages, 5 figure
Genetic Studies of Sulfadiazine-resistant and Methionine-requiring \u3cem\u3eNeisseria\u3c/em\u3e Isolated From Clinical Material
Deoxyribonucleate (DNA) preparations were extracted from Neisseria meningitidis (four isolates from spinal fluid and blood) and N. gonorrhoeae strains, all of which were resistant to sulfadiazine upon primary isolation. These DNA preparations, together with others from in vitro mutants of N. meningitidis and N. perflava, were examined in transformation tests by using as recipient a drug-susceptible strain of N. meningitidis (Ne 15 Sul-s Met+) which was able to grow in a methionine-free defined medium. The sulfadiazine resistance typical of each donor was introduced into the uniform constitution of this recipient. Production of p-aminobenzoic acid was not significantly altered thereby. Transformants elicited by DNA from the N. meningitidis clinical isolates were resistant to at least 200 ÎŒg of sulfadiazine/ml, and did not show a requirement for methionine (Sul-r Met+). DNA from six strains of N. gonorrhoeae, which were isolated during the period of therapeutic use of sulfonamides, conveyed lower degrees of resistance and, invariably, a concurrent methionine requirement (Sul-r/Metâ). The requirement of these transformants, and that of in vitro mutants selected on sulfadiazine-agar, was satisfied by methionine, but not by vitamin B12, homocysteine, cystathionine, homoserine, or cysteine. Sul-r Met+ and Sul-r/Metâ loci could coexist in the same genome, but were segregated during transformation. On the other hand, the dual Sul-r/Metâ properties were not separated by recombination, but were eliminated together. DNA from various Sul-r/Metâ clones tested against recipients having nonidentical Sul-r/Metâ mutant sites yielded Sul-s Met+ transformants. The met locus involved is genetically complex, and will be a valuable tool for studies of genetic fine structure of members of Neisseria, and of genetic homology between species
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