13 research outputs found
Inverted Sinonasal Papilloma ā A Report of 31 Cases and Review of the Literature
Inverted papilloma is an epithelial neoplasm of the lateral nasal wall and adjacent
sinuses characterized by a marked propensity for recurrence and a significant association
with carcinoma In this retrospective study we present 31 cases treated by our departments
between 1982 and 1999. The aim was to compare our results to those of other
authors especially regarding surgical management. The male to female ratio of these
patients was 2:1 and most patients were in the 6th and 7th decades of life. Conservative
surgery was used in most cases as the initial treatment. The overall recurrence rate was
low and there were 3 cases associated with carcinoma. We conclude that the results of
conservative surgery in selected cases are comparable to those using radical methods. A
review of the literature is presented and particular attention is dedicated to the literature
concerning analysis of p53 expression, HPV and Epstein-Barr infection and apoptosis
in inverted papilloma
Possible Prognostic Significance of P53 and Ki 67 in Inverted Sinonasal Papilloma
The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma
of the lateral nasal wall and adjacent sinuses regarding their malignant potential and recurrence. 49 biopsies of the lateral
nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically
demonstrated p53 and Ki67 expression was measured and statistically valuated. p53 immunoreactivity
was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated
stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal
papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and,
in case of high Ki67, a hint toward possible recurrence
Possible Prognostic Significance of P53 and Ki 67 in Inverted Sinonasal Papilloma
The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma
of the lateral nasal wall and adjacent sinuses regarding their malignant potential and recurrence. 49 biopsies of the lateral
nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically
demonstrated p53 and Ki67 expression was measured and statistically valuated. p53 immunoreactivity
was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated
stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal
papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and,
in case of high Ki67, a hint toward possible recurrence
CLINICAL RECOMMENDATIONS FOR DIAGNOSIS, TREATMENT AND MONITORING OF PATIENTS WITH CANCER OF UNKNOWN PRIMARY SITE
Rak nepoznata primarnog podrijetla obuhvaÄa vrlo heterogenu skupinu razliÄitih malignih tumora koji se prezentiraju u metastatskoj fazi bolesti. Dijagnoza se postavlja na temelju patohistoloÅ”ke potvrde maligne bolesti uz nemoguÄnost dokaza postojanja primarnog tumora nijednom dostupnom dijagnostiÄkom metodom. Iako je opÄenito loÅ”e prognoze, prepoznati su prognostiÄki povoljni kliniÄki entiteti koji Äine temeljnu skupinu bolesnika za aktivno onkoloÅ”ko lijeÄenje. U tekstu koji slijedi sadržane su kliniÄke upute s ciljem standardizacije dijagnostiÄkih postupaka, lijeÄenja i praÄenja bolesnika s nepoznatim primarnim rakom u Republici Hrvatskoj.Cancer of unknown primary (CUP) site comprises very heterogeneous group of various malignant tumors presented in metastatic phase of the disease. Diagnosis is set when primary site remains unidentified after a thorough diagnostic evaluation in patients with histologically proven malignant metastatic disease. Despite poor prognosis in most patients, favorable prognostic clinical entities have been recognized constituting the most important group of patients for oncological treatment. The following text presents the clinical guidelines in order to standardize the diagnosis, treatment and follow-up of patients with cancer of unknown primary site in the Republic of Croatia
CLINICAL RECOMMENDATIONS FOR DIAGNOSIS, TREATMENT AND MONITORING OF PATIENTS WITH CANCER OF UNKNOWN PRIMARY SITE
Rak nepoznata primarnog podrijetla obuhvaÄa vrlo heterogenu skupinu razliÄitih malignih tumora koji se prezentiraju u metastatskoj fazi bolesti. Dijagnoza se postavlja na temelju patohistoloÅ”ke potvrde maligne bolesti uz nemoguÄnost dokaza postojanja primarnog tumora nijednom dostupnom dijagnostiÄkom metodom. Iako je opÄenito loÅ”e prognoze, prepoznati su prognostiÄki povoljni kliniÄki entiteti koji Äine temeljnu skupinu bolesnika za aktivno onkoloÅ”ko lijeÄenje. U tekstu koji slijedi sadržane su kliniÄke upute s ciljem standardizacije dijagnostiÄkih postupaka, lijeÄenja i praÄenja bolesnika s nepoznatim primarnim rakom u Republici Hrvatskoj.Cancer of unknown primary (CUP) site comprises very heterogeneous group of various malignant tumors presented in metastatic phase of the disease. Diagnosis is set when primary site remains unidentified after a thorough diagnostic evaluation in patients with histologically proven malignant metastatic disease. Despite poor prognosis in most patients, favorable prognostic clinical entities have been recognized constituting the most important group of patients for oncological treatment. The following text presents the clinical guidelines in order to standardize the diagnosis, treatment and follow-up of patients with cancer of unknown primary site in the Republic of Croatia
KliniÄke preporuke za dijagnozu, lijeÄenje i praÄenje bolesnika oboljelih od raka nepoznata primarnog podrijetla [Clinical recommendations for diagnosis, treatment and monitoring of patients with cancer of unknown primary site]
Cancer of unknown primary (CUP) site comprises very heterogeneous group of various malignant tumors presented in metastatic phase of the disease. Diagnosis is set when primary site remains unidentified after a thorough diagnostic evaluation in patients with histologically proven malignant metastatic disease. Despite poor prognosis in most patients, favorable prognostic clinical entities have been recognized constituting the most important group of patients for oncological treatment. The following text presents the clinical guidelines in order to standardize the diagnosis, treatment and follow-up of patients with cancer of unknown primary site in the Republic of Croatia
KliniÄke preporuke za dijagnozu, lijeÄenje i praÄenje bolesnika oboljelih od raka nepoznata primarnog podrijetla [Clinical recommendations for diagnosis, treatment and monitoring of patients with cancer of unknown primary site]
Cancer of unknown primary (CUP) site comprises very heterogeneous group of various malignant tumors presented in metastatic phase of the disease. Diagnosis is set when primary site remains unidentified after a thorough diagnostic evaluation in patients with histologically proven malignant metastatic disease. Despite poor prognosis in most patients, favorable prognostic clinical entities have been recognized constituting the most important group of patients for oncological treatment. The following text presents the clinical guidelines in order to standardize the diagnosis, treatment and follow-up of patients with cancer of unknown primary site in the Republic of Croatia
Spontaneous Resolution of Fourth Branchial Fistula Following Thyroid Surgery: Case Report
Fourth branchial pouch anomalies represent one of the rarest types of all branchial apparatus anomalies. They appear in the first lifedecade in a form of recurrent left-sided neck masses which demands surgical treatment. Accidental finding, appearance later in life and spontaneous resolving are really rare. We present a case of a 43-year-old man with accidental finding of asymptomatic fourth pouch cyst and fistula following follicular thyroid cancer surgery. The day after the surgery, suction bottle was filled with little white crumbs and the wound started to suppurate. Barium swallow revealed the presence of a fistulous canal that arose from the left pyriform sinus. Meanwhile, the pathologist confirmed the presence of a lateral neck cyst within this thyroid lobe. The patient was operated on but fistulous canal was not visualized. In the meantime, wound discharge ceased spontaneously. At 1-year follow up, the patient was still well and free from any symptoms. These anomalies may manifest not only in childhood but may stay asymptomatic for a long time. It seems that the fistula can resolve spontaneously and that conservative approach is an alternative to multiple surgical procedures
Inverted Sinonasal Papilloma ā A Report of 31 Cases and Review of the Literature
Inverted papilloma is an epithelial neoplasm of the lateral nasal wall and adjacent
sinuses characterized by a marked propensity for recurrence and a significant association
with carcinoma In this retrospective study we present 31 cases treated by our departments
between 1982 and 1999. The aim was to compare our results to those of other
authors especially regarding surgical management. The male to female ratio of these
patients was 2:1 and most patients were in the 6th and 7th decades of life. Conservative
surgery was used in most cases as the initial treatment. The overall recurrence rate was
low and there were 3 cases associated with carcinoma. We conclude that the results of
conservative surgery in selected cases are comparable to those using radical methods. A
review of the literature is presented and particular attention is dedicated to the literature
concerning analysis of p53 expression, HPV and Epstein-Barr infection and apoptosis
in inverted papilloma