Field evaluation of Bt cotton crop impact on nontarget pests: cotton aphid and boll weevil.

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Princípios e práticas ecológicas para o manejo de insetos-praga na agricultura.

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SECAGEM DE GRÃOS DE MILHO DO CERRADO EM UM SECADOR COMERCIAL DE FLUXOS MISTOS / DRYING CLOSED CORN GRAIN DRYER FLOW IN A COMMERCIAL MIXED

Objetivou-se avaliar os efeitos da temperatura do ar de secagem (80, 100 e 120 °C) e a redução dos teores de água na qualidade física e físico-química de grãos de milho (Zea mays L.) em um secador de fluxo mistos operando de forma continua. O delineamento experimental foi inteiramente casualizado, em esquema fatorial (7x3) (teores de água x temperaturas de secagem). A redução dos teores de água associados ao aumento da temperatura do ar de secagem reduziu o comprimento, a largura, a espessura, o volume, a esfericidade e a circularidade dos grãos de milho. Os índices de acidez e a porcentagem de cinzas aumentaram com a redução dos teores de água, não havendo diferenças entre as temperaturas do ar de secagem. A diminuição dos teores de água com o aumento da temperatura do ar de secagem aumentou a condutividade elétrica e reduziu a germinação dos grãos, não havendo diferença entre as temperaturas de 100 e 120 °C. Concluiu-se que, o processo de secagem contínua em secadores de fluxo misto de ar e produto na temperatura do ar de até 80 °C, não afetou negativamente a qualidade física e físico-química dos grãos de milho.</p

Avaliação do impacto do cultivo de algodoeiro Bt em campo sobre pragas não-alvo.

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Multifunctional Nanoparticles Based on a Single-Molecule Modification for the Treatment of Drug-Resistant Cancer

Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively explored for the treatment of MDR in cancer because of its ability to inhibit P-glycoprotein. Here, we have established multifunctional nanoparticles (MFNPs) using a single-molecule modification of TPGS, which can deliver a hydrophobic drug, paclitaxel (PTX), and a hydrophilic drug, fluorouracil (5-FU), and overcome MDR in cancer. Our data indicated that, when delivered into a PTX-resistant cell line using MFNPs, the combination of PTX and 5-FU was more cytotoxic than each agent individually

Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk.

BACKGROUND: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. AIMS: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. METHODS: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. RESULTS: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. CONCLUSIONS: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction