32 research outputs found
Randomized Trial of a Health Coaching Intervention to Enhance Retention in Care: California Collaborative Treatment Group 594.
Poor linkage, engagement and retention remain significant barriers in achieving HIV treatment goals in the US. HIV-infected persons entering or re-entering care across three Southern California academic HIV clinics, were randomized (1:1) to an Active, Linkage, Engagement, Retention and Treatment (ALERT) specialist for outreach and health coaching, or standard of care (SOC). The primary outcome of time to loss to follow up (LTFU) was compared using Cox proportional hazards regression modeling. No differences in the median time to LTFU (81.7 for ALERT versus 93.6 weeks for SOC; HR 1.27; p = 0.40), or time to ART initiation was observed (N = 116). Although, ALERT participants demonstrated worsening depressive symptomatology from baseline to week 48 compared to SOC (p = 0.02). The ALERT intervention did not improve engagement and retention in HIV care over SOC. Further studies are needed to determine how best to apply resources to improve retention and engagement
Astro2020 Science White Paper: Triggered High-Priority Observations of Dynamic Solar System Phenomena
Unexpected dynamic phenomena have surprised solar system observers in the
past and have led to important discoveries about solar system workings.
Observations at the initial stages of these events provide crucial information
on the physical processes at work. We advocate for long-term/permanent programs
on ground-based and space-based telescopes of all sizes - including Extremely
Large Telescopes (ELTs) - to conduct observations of high-priority dynamic
phenomena, based on a predefined set of triggering conditions. These programs
will ensure that the best initial dataset of the triggering event are taken;
separate additional observing programs will be required to study the temporal
evolution of these phenomena. While not a comprehensive list, the following are
notional examples of phenomena that are rare, that cannot be anticipated, and
that provide high-impact advances to our understandings of planetary processes.
Examples include: new cryovolcanic eruptions or plumes on ocean worlds; impacts
on Jupiter, Saturn, Uranus, or Neptune; extreme eruptions on Io; convective
superstorms on Saturn, Uranus, or Neptune; collisions within the asteroid belt
or other small-body populations; discovery of an interstellar object passing
through our solar system (e.g. 'Oumuamua); and responses of planetary
atmospheres to major solar flares or coronal mass ejections.Comment: Astro2020 white pape
Solar system Deep Time-Surveys of atmospheres, surfaces, and rings
Imaging and resolved spectroscopy reveal varying environmental conditions in
our dynamic solar system. Many key advances have focused on how these
conditions change over time. Observatory-level commitments to conduct annual
observations of solar system bodies would establish a long-term legacy
chronicling the evolution of dynamic planetary atmospheres, surfaces, and
rings. Science investigations will use these temporal datasets to address
potential biosignatures, circulation and evolution of atmospheres from the edge
of the habitable zone to the ice giants, orbital dynamics and planetary
seismology with ring systems, exchange between components in the planetary
system, and the migration and processing of volatiles on icy bodies, including
Ocean Worlds. The common factor among these diverse investigations is the need
for a very long campaign duration, and temporal sampling at an annual cadence.Comment: 10 pages, 4 figures: submitted for Astro2020 White Pape
Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma
<p>Abstract</p> <p>Background</p> <p>We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4<sup>+</sup>CD25<sup>HI</sup>Foxp3<sup>+ </sup>regulatory T cells and expanded melanoma-specific CD8<sup>+ </sup>T cells. The goal of this study was to assess the clinical efficacy of DAB/IL2 in an expanded cohort of stage IV melanoma patients.</p> <p>Methods</p> <p>In a single-center, phase II trial, DAB/IL2 (12 μg/kg; 4 daily doses; 21 day cycles) was administered to 60 unresectable stage IV melanoma patients and response rates were assessed using a combination of 2-[<sup>18 </sup>F]-fluoro-2-deoxy-glucose (FDG)-positron emission tomography (PET) and computed tomography (CT) imaging.</p> <p>Results</p> <p>After DAB/IL2 administration, 16.7% of the 60 patients had partial responses, 5% stable disease and 15% mixed responses. Importantly, 45.5% of the chemo/immuno-naïve sub-population (11/60 patients) experienced partial responses. One year survival was markedly higher in partial responders (80 ± 11.9%) relative to patients with progressive disease (23.7 ± 6.5%; <it>p </it>value < 0.001) and 40 ± 6.2% of the total DAB/IL2-treated population were alive at 1 year.</p> <p>Conclusions</p> <p>These data support the development of multi-center, randomized trials of DAB/IL2 as a monotherapy and in combination with other immunotherapeutic agents for the treatment of stage IV melanoma.</p> <p>Trial registration</p> <p><a href="http://www.clinicaltrials.gov/ct2/show/NCT00299689">NCT00299689</a></p
Emerging Capabilities for Detection and Characterization of Near-Earth Objects (NEOs)
Here we describe the status for the detection and characterization of Near- Earth Objects (NEO) with current and future observatories. A summary of the capabilities, limitations, and obtainable NEO parameters is provided. <p/