Values of integrated density and positive area in epidermis and dermis at 1 hour and 24 hour time points.

<p>* indicates p<0.05 and ** indicates p<0.01.</p

LSCM images of rigin delivery into excised human skin.

<p>Representative rigin (RIG) treated confocal laser scanning microscopy (CLSM) images of viable epidermis and dermis at 1 and 24 hour(s) are shown without and with microneedle (MN) delivery enhancement. Mosaic images of the viable epidermis and dermis (top row and bottom row, respectively) are shown at at 1 and 24 hour(s) after rigin delivery with microneedle enhancement. Each mosiac is 5×5 mm².</p

LSCM images of Pal-KTTKS delivery into excised human skin.

<p>Representative Pal-KTTKS treated confocal laser scanning microscopy (CLSM) images of viable epidermis and dermis at 1 and 24 hour(s) are shown without and with microneedle (MN) delivery enhancement. Mosaic images of the viable epidermis and dermis (top row and bottom row, respectively) are shown at at 1 and 24 hour(s) after Pal-KTTKS delivery with microneedle enhancement. Each mosiac is 5×5 mm².</p

Integrated density and positive area data from rigin treated skin.

<p>Rigin (RIG) delivery characteristics are shown from epidermal (a and c) and dermal (d and d) mosiacs. Both the integrated density (a and b) and positive area (c and d) are shown for each microneedle site (MN). Data are shown for both 1 and 24 hours peptide exposure (1 h and 24 h, respecitvely). * indicates p<0.05. ** indicates p<0.01.</p

LSCM images of melanostatin delivery into excised human skin.

<p>Representative melanostatin (MEL) treated confocal laser scanning microscopy (CLSM) images of viable epidermis and dermis at 1 and 24 hour(s) are shown without and with microneedle (MN) delivery enhancement. Mosaic images of the viable epidermis and dermis (top row and bottom row, respectively) are shown at at 1 and 24 hour(s) after melanstatin delivery with microneedle enhancement. Each mosiac is 5×5 mm².</p

Integrated density and positive area data from melanostatin treated skin.

<p>Melanostatin (MEL) delivery characteristics are shown from epidermal (a and c) and dermal (d and d) mosiacs. Both the integrated density (a and b) and positive area (c and d) are shown for each microneedle site (MN). Data are shown for both 1 and 24 hours peptide exposure (1 h and 24 h, respecitvely). * indicates p<0.05. ** indicates p<0.01.</p