Multivariate regression analysis considering grade 2 breast cancers regarding the CIN4 score and clinicopathological variables.

<p>Multiple variables tested in separate runs when CIN4 was included (1–3a) or excluded (1–3b) from the comparison.</p

Clinicopathological data of the 185 breast cancer patients included in the analysis.

<p>Clinicopathological data of the 185 breast cancer patients included in the analysis.</p

CIN4 expression correlates with ploidy.

<p>A) Regression curve showing relation of CIN4 expression signature and DNA index (p = 0.036). B) Bar graph showing numbers of diploid and aneuploid cases grouped according to histological grade: grade 3 tumors are relatively enriched in aneuploid cancers.</p

CIN4 and ploidy and their relation to pathological variables.

<p>Relation of CIN4 and DNA index to A) and B) mitotic index, C) and D) Ki67 expression, E) and F) Nottingham Prognostic Index and G) and H) tumor size displayed with regression curves (coefficients and p-values on graphs).</p