Echocardiographic parameters for the study subjects.

<p>The parameters are referred to as mean ± SD. Abbreviations: LVEDD left ventricular (LV) internal diameter in diastole, LVESD LV internal diameter in systole, LVEF left ventricular ejection fraction, MWT maximum wall thickness, LV Mass left ventricular mass, LAD left atrium diameter, LVOT gradient left ventricular outflow tract gradient, MV E velocity mitral valve E-wave peak velocity, TDI Lateral Sm TDI peak systolic velocity at lateral mitral annulus, TDI Septal Sm TDI peak systolic velocity at septal mitral annulus, TDI Septal Em TDI peak early diastolic velocity at septal mitral annulus, TDI Lateral Em peak early diastolic velocity at lateral mitral annulus. P-values are given as one-way ANOVA. Pairwise comparisons with Bonferroni corrected p-values are labeled:</p><p>^aP<0.05 between G+/LVH+ and control group,</p><p>^bP<0.05 between G+/LVH+ and G+/LVH-,</p><p>^cP<0.05 between G+/LVH- and control group.</p><p>Echocardiographic parameters for the study subjects.</p

Mean metabolite-levels for significant molecular lipids and polar metabolites.

<p>The metabolite-levels are referred to as mean±SD. Abbreviations: PE phosphatidylethanolamine, PC phosphatidylcholine, TG triglyceride. P-values are given as one-way ANOVA. Pairwise comparisons with Tukey’s range test corrected p-values are labeled:</p><p>^aP<0.05 between G+/LVH+ and control group, given as Tukey’s range test.</p><p>^bP<0.05 between G+/LVH+ and G+/LVH-, given as Tukey’s range test.</p><p>*Not significant</p><p>Mean metabolite-levels for significant molecular lipids and polar metabolites.</p

Correlation heatmap and scatterplots.

<p>(a) Heatmap of Spearman product-moment correlation coefficients between metabolites and echocardiographic parameters for pooled G+/LVH- and G+/LVH+ groups. The colors represent the correlation, with red being more positive and blue more negative. Significance is given as *(<i>p</i><0.05), **(<i>p</i><0.01) and ***(<i>p</i><0.001). (b) Scatterplots showing the relationship between lysoPE(18:2) and MWT (left), and PE(40:8e) and MWT (right).</p

Description of metabolite clusters from the lipidomics (LC) and metabolomics (MC) platforms.

<p>Abbreviations: PC phosphatidylcholine, PE phosphatidylethanolamine, TG triglyceride, ChoE cholesteryl ester, SM sphingomyelin, PUFA polyunsaturated fatty acid, lysoPC lysophosphatidylcholine.</p><p>Description of metabolite clusters from the lipidomics (LC) and metabolomics (MC) platforms.</p

Clinical characteristics of the <i>MYBPC3</i>-Q1061X mutation carriers (G+) and control group.

<p>Values are presented as mean ± SD or count and percentage, with p-values for T-test or Fisher’s exact test between groups. NYHA = New York Heart Association functional class, LDL = low-density lipoprotein, HDL = high-density lipoprotein.</p><p>Clinical characteristics of the <i>MYBPC3</i>-Q1061X mutation carriers (G+) and control group.</p