Comparison of temporal changes in electrolytes and hemoglobin (means ± SEM).

<p>Weekly measurements of electrolytes and hemoglobin levels in pig groups: MAIZE (n = 12), AGE-REF (n = 12). Differences in means *(p<0.05), ** (p<0.01), *** (p<0.001).</p

Body and heart dimensions at the end of the experiment^*.

<p><b>*</b> Differences reported here for all pigs are also seen among the subsample of pigs used in echocardiography.</p><p>Data are (means ± sd).</p><p>^a,b,c Means not sharing a superscript are different (p<0.05).</p><p>Body and heart dimensions at the end of the experiment^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140472#t002fn001" target="_blank">*</a>}.</p

Comparison of temporal changes in plasma proANP, creatinine and urea (means ± SEM).

<p>Weekly measurements from pig groups: MAIZE (n = 12), AGE-REF (n = 12). Differences in means *(p<0.05), ** (p<0.01), *** (p<0.001).</p

Comparison of cardiac Troponin T release.

<p>Weekly measurements of cardiac Troponin T release in individual pigs: MAIZE (n = 12), AGE-REF (n = 12). Blood samples at killing week 7 drawn by cardiac puncturing and not shown.</p

Myocardial Performance Index (MPI) derived by color tissue Doppler echocardiography.

<p><i>Top</i>: Apical left 4-chamber view in end-systole showing the position of M-mode line used for measurement of cardiac intervals. <i>Bottom</i>: Colour diagram of the tissue Doppler imaging M-mode of the anterior mitral leaflet. a = interval from mitral valve closing to opening; b = ejection time. Myocardial performance index = (a—b)/ b = 355 ms– 236 ms/236 ms = 0.50.</p

Macronutrient composition of experimental diets^*.

<p><b>*</b> Diet composition is listed in detail elsewhere [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140472#pone.0140472.ref027" target="_blank">27</a>].</p><p>Macronutrient composition of experimental diets^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140472#t001fn001" target="_blank">*</a>}.</p

Comparison of Myocardial performance index (MPI), Isovolumic relaxation time (IVRT) Isovolumic contraction time (IRCT) and Ejection time (ET) (means ± SEM).

<p>Measurements from individual pigs: MAIZE (n = 8), AGE-REF (n = 8), WEIGHT-REF (n = 8). ^a,b,cMeans not sharing a letter in their superscript are significantly different (p<0.05).</p

Comparison of myocardial Na⁺/K⁺-ATPase density (means ± SEM).

<p>Measurements of Na⁺/K⁺-ATPase density expressed as ouabain-binding sites in myocardial tissue of individual pigs: MAIZE (n = 9), AGE-REF (n = 11), WEIGHT-REF (n = 8).^a,b,cMeans not sharing a letter in their superscript are significantly different (p<0.001). ww = wet weight.</p

Echocardiography results^*.

<p><b>*</b> Data are (means ± sd).</p><p>^a,b,c Means not sharing a superscript are different (p<0.05).</p><p>Echocardiography results^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140472#t003fn001" target="_blank">*</a>}.</p

Body composition after refeeding period of malnourished piglets with CSB+, CSB+/wp or CSB++ or continuously malnourished (REF) for 3 weeks.¹^,³.

<p>Body composition after refeeding period of malnourished piglets with CSB+, CSB+/wp or CSB++ or continuously malnourished (REF) for 3 weeks.<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0170043#t002fn001" target="_blank">¹</a>^,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0170043#t002fn003" target="_blank">³</a>.</p