1 research outputs found
Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from <i>Edgeworthia chrysantha</i>
Edgeworthianins A–E (1–5) were isolated from Edgeworthia chrysantha as a
class of macrocyclic daphnane orthoesters with an unusual macrocyclic
ring formed from a C14 aliphatic chain. Their structures were elucidated
by extensive physicochemical and spectroscopic analyses. Compounds 2, 4, and 5 exhibited potent anti-HIV
activity against HIV-1 infection of MT4 cells with EC50 values of 29.3, 8.4, and 2.9 nM, respectively. These compounds broaden
the findings of the structure–activity relationship of macrocyclic
daphnane orthoesters for further anti-HIV drug development