A Case of Severe Hemorrhagic Cystitis Caused by Melphalan with Successful Bladder Preservation by Ligation of Bilateral Internal Iliac Arteries

Hemorrhagic cystitis is a disorder which causes bleeding from diffusely inflammatory bladder mucosa. Here we present a case of severe hemorrhagic cystitis caused by melphalan. A 70-year-old man with multiple myeloma was presented with suddenly commenced massive gross hematuria. During an attempt of transurethral coagulation of bladder mucosa, bladder perforation into peritoneal cavity was suspected, then open laparotomy was indicated. We isolated bilateral internal iliac arteries and ligated them in order to control continued bleeding. After that, bladder bleeding was suddenly diminished. Ligation of internal iliac arteries may be a choice in controlling massive bleeding from bladder with severe hemorrhagic cystitis when laparotomy was inevitable

頭頸部癌細胞におけるレスベラトロールのREG III発現誘導効果と癌の進展抑制・治療向上効果

Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.博士（医学）・甲第682号・平成30年3月15日Copyright © Spandidos Publications 2017. All rights reserved.The Spandidos Publications link is available at " https://doi.org/10.3892/ijo.2016.3664

An Efficiency Degradation Model of Power Amplifier and the Impact against Transmission Power Control for Wireless Sensor Networks

Abstract—To extend an available period of wireless sensor networks, transmission power control is regarded as one of the promising schemes. In most of the previous studies on the transmission power control, it is assumed that a transmitter has power consumption of O(dn), where d and n denote a maximum communication distance and a pass loss factor. This assumption would substantially hold under the condition that the transmission efficiency is always constant at any transmission power (efficiency-fixed model). In practice, however, the trans-mission efficiency degrades as the transmission power is reduced. We analytically verify that an actual power amplifier with the efficiency degradation has a power consumption of O(dr), where n/2.8 ≤ r ≤ n/2 (efficiency-degradation model). The efficiency-degradation model gives the negative impact against the transmission power control. Index Terms—Wireless sensor network, transmission power control, transmission efficiency, pass loss factor. I

Test of High Temperature Superconducting REBCO Coil Assembly for a Multi-Frequency ECR Ion Source

Chong T.H., Fukuda M., Yorita T., et al. Test of High Temperature Superconducting REBCO Coil Assembly for a Multi-Frequency ECR Ion Source. IEEE Transactions on Applied Superconductivity 34, 1 (2024); https://doi.org/10.1109/TASC.2024.3360935.High temperature superconducting REBCO tape has the characteristic of maintaining high critical current density under strong external magnetic field, which makes it an ideal material for the construction of air-core electromagnets of accelerator and electron cyclotron resonance (ECR) ion source. In Research Center for Nuclear Physics, Osaka University, a non-insulated air-cored REBCO coil assembly has been constructed. This coil assebmly consists of three circular REBCO solenoid and six racetrack REBCO coil. This coil assembly will be used as an electromagnet of a multi-frequency ECR ion source, and is also developed as a key technology development of an air-core cyclotron. The magnetic field of this ion source are designed, and 77 K performance tests of the assembly are carried out in order to examine the capability of REBCO coils of inducing magnetic field under external field. In this work, the test results and the magnetic field designed for the ECR ion source will be presented and discussed

Study on Building a Traceability System for Whale Meat

Whale meat has been one of traditional diets in Japan. However whaling is now prohibited except for the purpose of scientific research. Therefore it is important to keep an eye on poaching and to make distribution routes clear to obtain an international credibility. Then it is highly required to build a pilot traceability system and test it immediately. On the basis of this context, we made a study on building a traceability system for whale meat. This study will contribute to clamping down any illegal trades of whale meat, ensuring safety of foods and wining confidence by consumers. This study is composed of following three studies. 1) Development of a technology, which makes it possible consumers to know the whale meat's history from its production through distribution by cellular phone. 2) Development of a technology, which makes it possible to prevent other species or poaching meat from mixing into, or to prevent a weight of whale meat from being manipulated during distribution. We developed these three basic systems by an examination with flatfish. As the next stage, we intend to examine whale meat traceability system in the field this year.Keywords: cellular phone, traceability, distribution, marine products, Fisheries Economics, Fish Processing, Marketing, And Consumptio

Enabling Secured Traceability of Fishery Products Using 2D Code and Digital Encryption

Technologies that enable traceability for fishery products are increasing their demands. Recently proposed technologies are mainly based on disposal RF(IC) tags which are able to record information directly onto them. However, the current systems based on RF tags have problems of expensive price of tags, and weakness of reading information if applied onto surface of products containing much water, which prevents to construct practically feasible systems using the RF tags. To provide a traceability system that uses much inexpensive media and that assures as high security as the RF tags, we propose a system based on a combination of printed 2D codes and internet connection, with security control similar to on-line electronic transactions. The proposed system identifies a fishery product by giving it a unique serial ID, which is issued by a database server, and printed in 2D code onto a paper or a plastic plate, which is directly put on the product. All the trace information sent from client (producer, transporters, and retailer) via internet is associated to the ID and stored to the server. Since 2D code is able to be read by such as mobile phones with built-in camera, a consumer is able to get history of the product with a single scanning operation. For the weakness of printed codes against duplication by copying, we propose a method to identify its validity by digital encryption, along with identification by weight information. The system is assured its usability by a series of experiments conducted for the distribution of cultured flounder in Hakodate, Japan.Keywords: Mobile Phone, Fisheries Economics, Falsification, Brand Fish, 2D Code, Fish Processing, Marketing, And Consumption, TraceabilityKeywords: Mobile Phone, Fisheries Economics, Falsification, Brand Fish, 2D Code, Fish Processing, Marketing, And Consumption, Traceabilit

State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice

Appropriately responding to various sensory signals in the environment is essential for animal survival. Accordingly, animal behaviors are closely related to external and internal states, which include the positive and negative emotional values of sensory signals triggered by environmental factors. While the lateral parabrachial nucleus (LPB) plays a key role in nociception and supports negative valences, it also transmits signals including positive valences. However, the downstream neuronal mechanisms of positive and negative valences have not been fully explored. In the present study, we investigated the ventral tegmental area (VTA) as a projection target for LPB neurons. Optogenetic activation of LPB-VTA terminals in male mice elicits positive reinforcement in an operant task and induces both avoidance and attraction in a place-conditioning task. Inhibition of glutamic acid decarboxylase (GAD) 65-expressing cells in the VTA promotes avoidance behavior induced by photoactivation of the LPB-VTA pathway. These findings indicate that the LPB-VTA pathway is one of the LPB outputs for the transmission of positive and negative valence signals, at least in part, with GABAergic modification in VTA