Indices of exhaled breath condensate in children with eosinophilic phenotype of bronchial asthma

The indices of exhaled air condensate have been studied in 160 children with different phenotypes of bronchial asthma. It has been demonstrated that there occur changes in children with the noneosinophilic phenotype of bronchial asthma as compared with the patients with the eosinophilic phenotype of the disease that are indicative of a higher activity of inflammatory processes in the respiratory tracts. The proteolytic activity according to azocasein lysis more than 1,5 ml/h had the highest diagnostic value of detection of noneosinophilic phenotype: spesiphity 84,7 %, the predictable value of a positive result 79,1 %, the odds ratio 7,5, the posttesting probability of positive result 79,1 %

Pharmacogenetic Aspects of Airways’ Obstruction Relief Therapy of Bronchial Asthma Attacks in Schoolchildren

On the base of a complex examination of 215 schoolchildren who suffer bronchial asthma, there have been established that clinical manifestations of severity of bronchial obstructive syndrome during disease exacerbation do not depend on acetylating status. However, a homozygosity on both alleles of the glutathione transferase gene (GSTT1+M1+) has been connected to greater severity of asthma attacks, while a lack of the T-allele in children with slow acetylating phenotype has been associated with more frequent use of systemic corticosteroids and somewhat better results of airways obstruction relief therapy. Occurrence of GSTT1+M1+ genotype in patients with accelerated processes of acetylation significantly increased the risk of the inefficiency of bronchial obstruction relief therapy (odds ratio 12.4, relative risk — 6.4, the absolute risk — 50 %)