Pharmacogenetic aspects of basic anti- inflammatory therapy of bronchial asthma in school-aged children under the deletion polymorphism of genes Gstt1 and Gstm1

Based on a comprehensive survey of 150 school-age children who suffer from bronchial asthma, there has been found that homozygosity for both alleles of the gene of glutathione transferase (GSTT1+ M1+) was associated with more frequent use both inhaled corticosteroids at 3 Step 3 of basic therapy and leukotriene modifiers as well as better asthma control level according to the ACT-test. Under the presence of such genotypes as GSTT1+ M1-, GSTT1-M1+ or GSTT1-M1-, the basic treatment was more likely within 2-nd and 4-th Steps by GINA recommendations, but the level of asthma control was worse in these children

Immunologycal Status of Children with Bronchial Asthma during Febrile Episodes

The aim of the research was to study the diagnostic value of some immunological tests for the verification of bacterial and/or viral infection during febrile episodes of bronchial asthma exacerbations in children. On the base of allergological unit of Chernivtsi Regional Child Hospital by the method of simple random sampling there have been examined 119 child patients with bronchial asthma who were admitted to the hospital due to asthma exacerbation caused by fever. They were divided into two groups of clinical observation. The analysis of clinical and laboratory data in children with bacterial and viral febrile bronchial asthma attacks revealed that such patients more likely had higher level of T-lymchocyte of various subpopulations and indices of NBT test neutrophils