Time in years from inclusion to development of CD or UC (based on 6 months postpartum).

<p>Time in years from inclusion to development of CD or UC (based on 6 months postpartum).</p

Time in years from inclusion to development of CD or UC (based on 6 months postpartum).

<p>Time in years from inclusion to development of CD or UC (based on 6 months postpartum).</p

Time from inclusion in the study to the development of CD and UC with no evidence of clustering of cases near the beginning of follow-up.

<p>Time from inclusion in the study to the development of CD and UC with no evidence of clustering of cases near the beginning of follow-up.</p

Cubic spines of BMI versus hazard ratio for the development of Crohn’s disease and ulcerative colitis separately in the under and over 40s at time of diagnosis for pre-pregnancy BMI and BMI 18 months after birth with 95% CIs.

<p>The probability that the splines for the under and over 40 years of age are different pre-pregnancy = 0.0575, and for the 18 months post delivery p = 0.0618. F or UC the respective probabilities were p = 0.4989 and p = 0.3395. The spline age 18-<40 and 95% Cis are shaded and the spline for age 40+ and 95% Cis are unshaded.</p

Hazard ratios (HRs with confidence intervals) of development of CD or UC according to body mass index (BMI; kg/m²) overall and divided into age groups before and after 40 years of age.

<p>Hazard ratios (HRs with confidence intervals) of development of CD or UC according to body mass index (BMI; kg/m²) overall and divided into age groups before and after 40 years of age.</p

Splines for waist: Height ratio 18 months after delivery and hazard ratios for the development of CD and UC with 95% CIs.

<p>For CD spline p = 0.0256 and for UC p = 0152. Test for trend for CD p = 0.9032 and for UC 0.059.</p

Cohort characteristics by BMI group (n = 74,512 pre-pregnancy / 48,262 18 months after delivery).

<p>Cohort characteristics by BMI group (n = 74,512 pre-pregnancy / 48,262 18 months after delivery).</p

Cubic splines of BMI versus hazard ratio for the development of Crohn’s disease and ulcerative colitis in both age groups combined for pre-pregnancy BMI and BMI 18 months after delivery.

<p>For pre-pregnancy BMI for the CD spline p = 0.2777 for UC 0.4146. For 18 months after delivery for CD p = 0.0354 and for UC p = 0.6359. 95% Cis are displayed.</p

CNS infections in Greenland: A nationwide register-based cohort study

<div><p>Background</p><p>Indigenous Arctic people suffer from high rates of infectious diseases. However, the burden of central nervous system (CNS) infections is poorly documented. This study aimed to estimate incidence rates and mortality of CNS infections among Inuits and non-Inuits in Greenland and in Denmark.</p><p>Methods</p><p>We conducted a nationwide cohort study using the populations of Greenland and Denmark 1990–2012. Information on CNS infection hospitalizations and pathogens was retrieved from national registries and laboratories. Incidence rates were estimated as cases per 100,000 person-years. Incidence rate ratios were calculated using log-linear Poisson-regression. Mortality was estimated using Kaplan-Meier curves and Log Rank test.</p><p>Results</p><p>The incidence rate of CNS infections was twice as high in Greenland (35.6 per 100,000 person years) as in Denmark (17.7 per 100,000 person years), but equally high among Inuits in Greenland and Denmark (38.2 and 35.4, respectively). Mortality from CNS infections was 2 fold higher among Inuits (10.5%) than among non-Inuits (4.8%) with a fivefold higher case fatality rate in Inuit toddlers.</p><p>Conclusion</p><p>Overall, Inuits living in Greenland and Denmark suffer from twice the rate of CNS infections compared with non-Inuits, and Inuit toddlers carried the highest risk of mortality. Further studies regarding risk factors such as genetic susceptibility, life style and socioeconomic factors are warranted.</p></div

One-month mortality after CNS infection among Inuits and non-Inuits in Greenland and Denmark, 1990–2012.

<p>The highest mortality was observed the first week after infection. Inuits in Greenland and Denmark carried the highest risk of mortality compared to non-Inuits in the two countries.</p