Measurement of double polarized asymmetries in quasi-elastic processes 3He⃗(e⃗,e′d){}^3\vec{He}(\vec{e},e' d) and 3He⃗(e⃗,e′p){}^3\vec{He}(\vec{e},e' p)

This thesis is dedicated to a study of a spin-isospin structure of the polarized ${}^3\mathrm{He}$. First, an introduction to the spin structure of ${}^3\mathrm{He}$ is given, followed by a brief overview of past experiments. The main focus of the thesis is the E05-102 experiment at Jefferson Lab, in which the reactions ${}^3\vec{\mathrm{He}}(\vec{\mathrm{e}},\mathrm{e'} \mathrm{d})$ and ${}^3\vec{\mathrm{He}}(\vec{\mathrm{e}},\mathrm{e'} \mathrm{p})$ in the quasi-elastic region were studied. The purpose of this experiment was to better understand the effects of the S'- and D-state contributions to the ${}^3\mathrm{He}$ ground-state wave-functions by a precise measurement of beam-target asymmetries $A_x$ and $A_z$ in the range of recoil momenta from 0 to about $300 \mathrm{MeV}/c$. The experimental equipment utilized in these measurements is described, with special attention devoted to the calibration of the hadron spectrometer, BigBite. Results on the measured asymmetries are presented, together with first attempts at their comparison to the state-of-the art Faddeev calculations. The remaining open problems and challenges for future work are also discussed.Comment: Doctoral thesis, 234 page

Enzymatic Baeyer-Villiger Oxidation of Benzo-Fused Ketones:Formation of Regiocomplementary Lactones

Baeyer-Villiger monooxygenases (BVMOs) are enzymes that are known to catalyse the Baeyer-Villiger oxidation of ketones in aqueous media using O(2) as oxidant. Herein, we describe the oxidation of a set of diverse benzo-fused ketones by three different BVMOs in both aqueous and non-conventional reaction media. Most of the tested ketones, for example, 1-tetralone and 1- and 2-indanone, were converted by one of the employed biocatalysts. The catalytic efficiency could be improved by performing the oxidation reactions at a relatively high pH and by adding organic cosolvents. One striking observation is that absolute and complementary regioselectivities were obtained when oxidizing a range of 1-indanones using two different BVMOs. The conversion of 1-indanone by 4-hydroxyacetophenone monooxygenase (HAPMO) results in the formation of the expected lactone, 3,4-dihydrocoumarin. In contrast, by using a phenylacetone monooxygenase mutein (M-PAMO), conversion of 1-indanone leads to the formation of only the unexpected lactone, 1-isochromanone. This illustrates that by the appropriate choice of BVMO as biocatalyst, the effective and regioselective conversion of a wide range of benzo-fused ketones is feasible. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009

Protección integral de derechos de mujeres y protección integral de derechos de niños y niñas

En la formación profesional del abogado es necesario que el egresado adquiera un idóneo manejo de herramientas jurídicas y de herramientas de perspectiva de género para la comprensión de la realidad en relación con la vinculación entre los derechos de las mujeres y los derechos de los niños y de las niñas. El 9 de junio de 1994 se aprueba, en el ámbito de la Organización de Estados Americanos (OEA) y con la intervención de la Comisión Interamericana de Mujeres (CIM), la Convención Interamericana para Prevenir, Sancionar y Erradicar la Violencia contra la Mujer, conocida como Convención de Belém do Pará. La Convención de Belém do Pará fue incorporada a nuestra legislación en 1996, por la ley Nº 24.632. La incorporación de la Convención sobre la Eliminación de Todas las Formas de Discriminación contra la Mujer (CEDAW) y la Convención de Belém do Pará constituyen la matriz en el ordenamiento normativo local para la protección integral de los derechos de las mujeres. En la Argentina, la Convención sobre la Eliminación de Todas las Formas de Discriminación contra la Mujer (CEDAW) y la Convención de Belém do Pará han sido los antecedentes ineludibles para la sanción de la ley Nº 26.485, “Ley de Protección Integral para Prevenir, Sancionar y Erradicar la Violencia contra las Mujeres en los Ámbitos en que Desarrollen sus Relaciones Interpersonales”, en 2009.Número extraordinario: En conmemoración del Aniversario de la Convención para Prevenir, Sancionar y Erradicar la Violencia contra la Mujer “Convención de Belém do Pará”Facultad de Ciencias Jurídicas y Sociale

Construction of a Xylanase A Variant Capable of Polymerization

The aim of our work is to furnish enzymes with polymerization ability by creating fusion constructs with the polymerizable protein, flagellin, the main component of bacterial flagellar filaments. The D3 domain of flagellin, exposed on the surface of flagellar filaments, is formed by the hypervariable central portion of the polypeptide chain. D3 is not essential for filament formation. The concept in this project is to replace the D3 domain with suitable monomeric enzymes without adversely affecting polymerization ability, and to assemble these chimeric flagellins into tubular nanostructures. To test the feasibility of this approach, xylanase A (XynA) from B. subtilis was chosen as a model enzyme for insertion into the central part of flagellin. With the help of genetic engineering, a fusion construct was created in which the D3 domain was replaced by XynA. The flagellin-XynA chimera exhibited catalytic activity as well as polymerization ability. These results demonstrate that polymerization ability can be introduced into various proteins, and building blocks for rationally designed assembly of filamentous nanostructures can be created

Measurement of Double-Polarization Asymmetries in the Quasielastic ³→He (→e, e\u27 d) Process

We present a precise measurement of double-polarization asymmetries in the ³→He (→e, e\u27 d) reaction. This particular process is a uniquely sensitive probe of hadron dynamics in 3He and the structure of the underlying electromagnetic currents. The measurements have been performed in and around quasielastic kinematics at Q2 = 0.25(GeV/c)2 for missing momenta up to 270 MeV/c. The asymmetries are in fair agreement with the state-of-the-art calculations in terms of their functional dependencies on pm and ω, but are systematically offset. Beyond the region of the quasielastic peak, the discrepancies become even more pronounced. Thus, our measurements have been able to reveal deficiencies in the most sophisticated calculations of the three-body nuclear system, and indicate that further refinement in the treatment of their two-and/or three-body dynamics is required