Vizualno ispitivanje stanja motora zrakoplova

U radu je obrađena primjena vizualne metode, preciznije boroskopije, u ispitivanju komponenata turboventilatorskog motora (CFM56-5B), tijekom planiranog pregleda zrakoplova. Boroskopija se primjenjuje u raznim ispitivanjima stanja unutrašnjosti cijevovoda, lopatica rotora, komora za izgaranje, plinskih cilindara, malih spremnika, itd., gdje je teško provesti ispitivanje golim okom ili jednostavnim optičkim pomagalima. Velika prednost boroskopije je kontrola određenog dijela bez potrebe za rastavljanjem cijelog motora ili dijela konstrukcije zrakoplova, što oduzima puno vremena i povećava troškove održavanja. Prikazane su procedure i načini izvođenja boroskopije na svim pozicijama motora, s detaljnijim osvrtom na izvođenje ispitivanja lopatica visokotlačne turbine te analizu dobivenih rezultata (detekcije nepravilnosti u strukturi materijala)

Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia

Recent studies suggest that chronic inflammation is crucial in the development and progression of prostate cancer (CaP). Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in intraprostatic inflammation and thus carcinogenesis. The –174G>C polymorphism of IL-6 gene has been associated with high IL-6 producer pheno- type and an increased risk for CaP . The aim of this study was to evaluate the association between the mentioned IL-6 polymorphism and CaP risk, as well as to compare the genotype frequency between the different tumour grades of CaP , in population of Eastern Croatia. We analyzed the IL-6 polymorphism in 120 CaP patients and 120 controls with benign prostatic hyperplasia (BPH). CaP patients and BPH controls did not statistically differ in studied IL-6 polymorphism. Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p=0.147). Also, no statistically significant difference in IL-6 high and low producer genotype fre- quency was noticed between well, moderately and poorly differentiated tumours. Our results, taken together with other studies on the subject, suggest that IL-6 – 174 single nucleotide polymorphism (SNP) distribution may differ between various ethnic groups and that a single cytokine gene polymorphism has probably just a minor effect on CaP susceptibil- ity. Further studies should be performed to clarify the link between SNPs of different cytokines and the risk for CaP

CYSTINE UROLITHIASIS: RECOMMENDATIONS FOR DIAGNOSIS, TREATMENT AND RECURRENCE PREVENTION

Cistinska litijaza dijagnostički je i terapijski izazov, a u našoj literaturi do sada nije bilo ujedinjenih prikaza kako valja postupati s ovakvim bolesnicima. Ovaj dokument rezultat je rasprava na tom sastanku uz nadogradnju nakon simpozija putem elektroničkih sjednica i ekspertno je mišljenje stručnjaka. Nadamo se da će članak biti od praktične koristi brojnim kolegama koji se susreću s problemom litijaze, a one koji to rjeđe imaju prilike, podsjetit će na ovaj oblik kamenaca mokraćnog sustava. Ovaj dokument namijenjen je primarno urolozima i nefrolozima, ali i svim općim internistima te liječnicima obiteljske medicine jer će svima, vjerujemo, olakšati razmišljanja kada se suoče s takvim bolesnikom.Cystine lithiasis is a diagnostic and therapeutic challenge. This consensus document has outgrown of discussion of experts in nephrology and urology. It is our hope that this document will be of use for all physicians who are facing this disturbing type of urolithiasis. So far, in our national literature there have been no comprehensive documents dealing with this entity and we believe that not only nephrologists and urologists will benefit, but also specialists in internal medicine and general practitioners

Utjecaj skladištenja kontroliranom atmosferom na kvalitetu hrvatskih tradicionalnih sorti jabuke

The aim of this work was to investigate the influence of cold storage at 2 °C for 180 days on water content, total acids, reducing and total sugar, antioxidant activity, polyphenol oxidase activity, and polyphenol profile of three Croatian traditional apple cultivars (‘Kanadska Reneta’, ‘Ilzer Rosenapfel’, ‘Wagener’). A significant variation in polyphenol profile of apple cultivars under investigation was noted. The most represented polyphenols in all apple cultivars were procyanidin B2 followed by chlorogenic acid, epigallocatechin, epicatechin, and phloridzin. After storage, the content of procyanidin B2 and chlorogenic acid was higher, while content of epigallocatechin after storage was lower in all investigated apple cultivars. Water content before storage ranged between 79.17 and 80.76 %, and after storage between 75.62 and 78.56 %. Total acids, polyphenol oxidase activity, and flavonoids had decreased during storage, while reducing and total sugar content was higher after storage. Moreover, after storage, cultivar ‘Kanadska Reneta’ had the highest antioxidant activity measured by both ABTS and DPPH methods, 1.65 and 0.70 mmol trolox kg–1, respectively. A significant variation in polyphenol profile of apple cultivars under investigation was noted. The most represented polyphenols in all apple cultivars were procyanidin B2, followed by chlorogenic acid, epigallocatechin, epicatechin, and phloridzin. After storage, the content of procyanidin B2 and chlorogenic acid was higher, while content of epigallocatechin after storage was lower in all investigated apple cultivars. Overall, it can be concluded that investigated apple cultivars, after storage, preserved most of the antioxidants and functional properties.Cilj ovog rada bio je istražiti utjecaj skladištenja kontroliranom atmosferom na 2 °C tijekom 180 dana na polifenolni profil, sadržaj vode, ukupne kiseline, reducirajuće i ukupne šećere, antioksidacijsku aktivnost i aktivnost polifenol oksidaze triju hrvatskih tradicionalnih sorti jabuke (´Kanadska Reneta’, ‘Ilzer Rosenapfel’, ‘Wagener’). Uočena je značajna varijacija u profilu polifenola ispitivanih sorti jabuke. Najzastupljeniji polifenoli kod svih sorti jabuke bili su procijanidin B2, zatim klorogenska kiselina, epigalokatehin, epikatehin i floridzin. Nakon skladištenja sadržaj procijanidina B2 i klorogenske kiseline bio je veći, dok je sadržaj epigalokatehina nakon skladištenja bio manji kod svih ispitivanih sorti jabuke. Sadržaj vode prije skladištenja kretao se između 79,17 i 80,76 %, a nakon skladištenja između 75,62 i 78,56 %. Tijekom skladištenja došlo je do smanjenja ukupnih kiselina, aktivnosti polifenol oksidaze i udjela flavonoida, dok je sadržaj ukupnih šećera bio veći nakon skladištenja. Štoviše, sorta ‘Kanadska Reneta’ nakon skladištenja imala je najveću antioksidacijsku aktivnost mjerenu ABTS i DPPH metodom, 1,65 odnosno 0,70 mmol trolox/kg–1. Uočena je značajna varijacija u polifenolnom profilu ispitivanih sorti jabuke. Najzastupljeniji polifenoli kod svih sorti jabuke bili su procijanidin B2, zatim klorogenska kiselina, epigalokatehin, epikatehin i floridzin. Nakon skladištenja sadržaj procijanidina B2 i klorogenske kiseline bio je veći, dok je sadržaj epigalokatehina nakon skladištenja bio niži kod svih ispitivanih sorti jabuke. Sveukupno se može zaključiti da su ispitivane sorte jabuka nakon skladištenja sačuvale najveći dio antioksidativnih i funkcionalnih svojstava

Definition of Acetylsalicylic Acid Resistance Using Whole Blood Impedance Aggregometry in Patients Undergoing Coronary Artery Surgery

A beneficial effect of acetylsalicylic acid (ASA) on vein graft patency has been described, but some patients experience adverse cardiac events despite appropriate ASA treatment. Study aim was to define ASA resistance using Multiple elec- trode aggregometry (MEA) preoperatively in group of patients undergoing coronary artery bypass grafting (CABG). Pro- spective observational trial at University Hospital Center Zagreb enrolled 131 patients scheduled for CABG, and divided them into 4 groups with respect to preoperative antiplatelet therapy (APT). Group 1 received 100 mg ASA per day, Group 2 100 mg ASA + 75 mg clopidogrel per day, Group 3 75 mg clopidogrel per day, and Group 4 did not receive any APT. MEA with ASPI test (sensitive to ASA) and ADP test (sensitive to clopidogrel) was performed prior to surgery. In Group 1, patients were characterized as ASA resistant if their ASPI test value exceeded the 75 th percentile distribution. Study en- rolled 131 patients. Significant differences both in the ASPI (p<0.001) and the ADP test (p=0.038) were observed be- tween patients in different APT groups. In Group (1) ASPI test value of 30 AUC presented 75 th percentile of distribution, thus indicating ASA resistance. Group 2 patients had slightly lower ADP test values, but no significant difference oc- curred (mean 60.05 vs. 63.32 AUC, p=0.469). In Group 1 and 2, significant correlations between the ADP test and both, platelet count (r=0.347, p<0.001) and fibrinogen level (r=0.364, p<0.001) were observed. Association between low re- sponse to ASA and post-CABG major adverse ischemic events risk increase has been described thus indicating need for ASA resistant patients detection. In patients with preoperative ASPI test exceeding 30 AUC postoperative, ASA dose ad- justment or clopidogrel addition according to MEA results should be considered

Analiza rešetkastih panela kompozitnih zrakoplovnih konstrukcija

Predmet ovog diplomskog rada je analiza čvrstoće i gubitka stabilnosti kompozitnog rešetkastog panela. Rezultati rešetkastog panela usporedit će se s rezultatima dobivenih iz analiza čvrstoće standardnih panela pri identičnom opterećenju. Također, vrednovat će se mogućnosti i učinkovitost analitičkog programa HyperSizer pri analizi i dimenzioniranju kompozitnog panela. U drugom poglavlju ukratko su navedeni povijest, primjena, prednosti i nedostaci rešetkastih konstrukcija u zrakoplovstvu i svemirskim programima. Treće poglavlje podijeljeno je u četiri dijela. Sadrži općenite informacije o analitičkim izrazima i temeljne relacije na kojima je baziran rad programa HyperSizer. \Na kraju poglavlja opisani su kriteriji popuštanja analizirani u petom poglavlju. U četvrtom poglavlju opisani su modeli na kojima su se vršile analitičke i numeričke analize. Zadana su opterećenja i rubni uvjeti za dva promatrana slučaja. Dane su i glavne karakteristike ortotropnog kompozitnog materijala korištenog u analizi. Peto poglavlje sadrži rezultate analiza, popraćene zapažanjima i komentarima. \Na kraju je dan zaključak s osvrtom na dobivene rezultate provedenih analiza