3 research outputs found

    Basic methods for investigating and proving sickle-cell anemia

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    Π’ΡŠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅: Π‘ΡŠΡ€ΠΏΠΎΠ²ΠΈΠ΄Π½ΠΎ-ΠΊΠ»Π΅Ρ‚ΡŠΡ‡Π½Π°Ρ‚Π° анСмия (БКА) Π΅ Π³Π΅Π½Π΅Ρ‚ΠΈΡ‡Π½ΠΎ Π΄Π΅Ρ‚Π΅Ρ€ΠΌΠΈΠ½ΠΈΡ€Π°Π½ΠΎ заболяванС, прСдставляващо сСриозСн общСствСн Π·Π΄Ρ€Π°Π²Π΅Π½ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ Π½Π΅ само Π·Π° странитС с Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½ΠΎ висока чСстота (Африка, Азия, АмСрика, Π‘Ρ€Π΅Π΄ΠΈΠ·Π΅ΠΌΠ½ΠΎΠΌΠΎΡ€ΠΈΠ΅), Π½ΠΎ ΠΈ Π·Π° мноТСство ΠΎΡ‚ СвропСйскитС страни, ΠΊΡŠΠ΄Π΅Ρ‚ΠΎ сС наблюдава Π½Π΅ΠΏΡ€Π΅ΠΊΡŠΡΠ½Π°Ρ‚ΠΎ нарастванС Π½Π° чСстотата Π½Π° Ρ‚ΠΎΠ²Π° заболяванС. Π¦Π΅Π»: Π”Π° прСдставим ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ, ΠΈΠ·ΠΏΠΎΠ»Π·Π²Π°Π½ΠΈ Π·Π° скриниранС ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π½Π° БКА. Дискусия: ΠœΠ΅Ρ‚ΠΎΠ΄ΠΈΡ‚Π΅, ΠΈΠ·ΠΏΠΎΠ»Π·Π²Π°Π½ΠΈ ΠΏΡ€ΠΈ скриниранС ΠΈ диагностициранС Π½Π° БКА са Π΄Π²Π° основни Ρ‚ΠΈΠΏΠ°: Ρ€ΡƒΡ‚ΠΈΠ½Π½ΠΈ ΠΈ високо спСциализирани Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ. Π ΡƒΡ‚ΠΈΠ½Π½ΠΈΡ‚Π΅ тСстовС Π²ΠΊΠ»ΡŽΡ‡Π²Π°Ρ‚ ПКК, Π±ΠΈΠΎΡ…ΠΈΠΌΠΈΡ‡Π½ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Π·Π° Π΄ΠΎΠΊΠ°Π·Π²Π°Π½Π΅ Π½Π° Ρ…Π΅ΠΌΠΎΠ»ΠΈΠ·Π° in vivo, изслСдванС Π½Π° ΡƒΡ€ΠΈΠ½Π°, ΠΊΠ°ΠΊΡ‚ΠΎ ΠΈ скриниращитС тСстовС Π·Π° Π΄ΠΎΠΊΠ°Π·Π²Π°Π½Π΅ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅Ρ‚ΠΎ Π½Π° HbS - тСстовС Π·Π° разтворимост, тСстовС, ΠΏΡ€Π΅Π΄ΠΈΠ·Π²ΠΈΠΊΠ²Π°Ρ‰ΠΈ промяна във Ρ„ΠΎΡ€ΠΌΠ°Ρ‚Π° Π½Π° Π΅Ρ€ΠΈΡ‚Ρ€ΠΎΡ†ΠΈΡ‚ΠΈΡ‚Π΅ ΠΈ Π΄Ρ€. ΠžΡ‚ ΠΈΠ·ΠΊΠ»ΡŽΡ‡ΠΈΡ‚Π΅Π»Π½ΠΎ Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ Π·Π° ΠΏΠΎΡ‚Π²ΡŠΡ€ΠΆΠ΄Π°Π²Π°Π½Π΅ Π½Π° Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π΅ ΠΈΠ·ΠΏΠΎΠ»Π·Π²Π°Π½Π΅Ρ‚ΠΎ Π½Π° високо спСциализирани Ρ‚Π΅Ρ…Π½ΠΈΠΊΠΈ Π·Π° раздСлянС Π½Π° Π±Π΅Π»Ρ‚ΡŠΡ†ΠΈ ΠΊΠ°Ρ‚ΠΎ Π΅Π»Π΅ΠΊΡ‚Ρ€ΠΎΡ„ΠΎΡ€Π΅Π·Π° ΠΈ високоСфСктивна Ρ‚Π΅Ρ‡Π½Π° хроматография (HPLC), опрСдСлящи Π°Π±Π½ΠΎΡ€ΠΌΠ½ΠΈΡ‚Π΅ Ρ…Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΠΈ Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΈ. Π—Π° Π½ΡƒΠΆΠ΄ΠΈΡ‚Π΅ Π½Π° ΠΏΡ€Π΅Π½Π°Ρ‚Π°Π»Π½Π°Ρ‚Π° диагностика сС ΠΈΠ·ΠΏΠΎΠ»Π·Π²Π° ΠΈ Π”ΠΠš Π°Π½Π°Π»ΠΈΠ· Π·Π° Π΄ΠΎΠΊΠ°Π·Π²Π°Π½Π΅ Π½Π° Ρ‚ΠΎΡ‡ΠΊΠΎΠ²Π° мутация Π² Π³Π΅Π½Π° Π·Π° Π±Π΅Ρ‚Π° Π²Π΅Ρ€ΠΈΠ³Π°Ρ‚Π° Π½Π° Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²Π°Ρ‚Π° ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»Π°. Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅: НСобходимо Π΅ Π΄Π° сС ΠΏΠΎΠ·Π½Π°Π²Π°Ρ‚ Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΈΡ‚Π΅ Π²ΠΈΠ΄ΠΎΠ²Π΅ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ Π·Π° скриниранС ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π½Π° БКА, Π·Π° Π΄Π° Π΅ максимално Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π΅Π½ ΠΈ Π±ΡŠΡ€Π· диагностичният процСс ΠΏΡ€ΠΈ Ρ‚ΠΎΠ²Π° разпространСно ΠΈ Π½Π΅ рядко Ρ‚Π΅ΠΆΠΊΠΎ ΠΏΡ€ΠΎΡ‚ΠΈΡ‡Π°Ρ‰ΠΎ наслСдствСно заболяванС.Introduction: The sickle-cell anaemia (SCA) is a genetically determined disease, that is a major public health issue amongst not only the countries where it is traditionally quite common (Africa, Asia, America and the Mediterranean), but also the majority of European countries, where a significant increase of the frequency of the disease is observed. Aim: To present methods used for screening and diagnose of SCA. Discussion: The methods used for screening and diagnose of SCA can be classified into two main categories - routine ones and highly specialised laboratory methods. The routine tests include complete blood count, biochemical parameters to prove in vivo haemolysis, urine tests and the screening tests for presence of HbS e.g. sickling tests and solubility tests. In order to confirm the diagnosis of SCA the usage of protein separation techniques such as electrophoresis and high-performance liquid chromatography (HPLC) for detection of abnormal hemoglobin variants is of high importance. Concerning prenatal diagnostics DNA analysis is also used for detection of point mutation in the fetus beta gene of globin molecule. Conclusion: In order to ensure with maximum of effectiveness the diagnostic process of this common hereditary disease, a good knowledge of all available screening and diagnostic methods is needed

    The advantages of new technologies in digital healthcare

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    mHealth has rapidly emerged as a powerful application, particularly in developing countries, thanks to the widespread adoption of mobile devices. It has become a crucial tool for expanding access to healthcare and improving the overall quality of health services. In the realm of mHealth, digital technology serves a variety of purposes. It enables greater accessibility to healthcare and health-related information, especially for hard-to-reach populations. It also enhances disease diagnosis and tracking, providing timely and accurate public health information. Furthermore, it offers expanded opportunities for ongoing medical education and training, benefiting healthcare professionals. This report highlights the transformative nature of digital health services and showcases the numerous advantages and benefits they bring to the healthcare sector

    Abstracts Of The Proceedings And The Posters From The Third Scientific Session Of The Medical College Of Varna

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    October 2-3, 201
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