Principal Component Analysis (47% of the total variance) performed considering mtDNA haplogroup frequencies of the ancient and present-day European and Near East populations.

<p>In green Neolithic populations, in pink Hunter-Gatherer groups (HG), in yellow ancient and present-day Romania groups, present-day European population in blue and present-day Near East population in orange. Interpretation based on the haplogroup frequency has been written on both PC (Absence of haplogroups D, M, C and N on one side of the first component and absence of haplogroup H on the top of the second component). PC1 represents 30% of variance and PC2 represents 17% of variance.</p

Geographic location of ten Romanian sites analyzed in the present study.

<p>(The figure has been provided by M. Rotea and T. Károly).</p

Haplotype (ht) and haplogroup (hg) mtDNA distribution resulting of the analysis of 62 ancient individuals from Romania.

<p>Haplotype (ht) and haplogroup (hg) mtDNA distribution resulting of the analysis of 62 ancient individuals from Romania.</p

Multidimensional Scaling Analysis performed by haplogroup frequencies of the ancient and present-day European and Near East populations.

<p>In green Neolithic populations, in pink hunter-gatherer groups and in yellow ancient and present-day Romanian groups, present-day European population in blue and present-day Near East population in orange. Stress: 0.07553 and RSQ: 0.99071.</p

Prehistoric samples from Romania analysed in the present study: Chronology, Cultural stages (also in Supporting Information S1 Table), Archaeological sites and Sample size (I.D.: Identification name; N analysed: Number of individuals analysed; N rep: number of individuals with reproducibility results).

<p>Prehistoric samples from Romania analysed in the present study: Chronology, Cultural stages (also in Supporting Information <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128810#pone.0128810.s009" target="_blank">S1 Table</a>), Archaeological sites and Sample size (I.D.: Identification name; N analysed: Number of individuals analysed; N rep: number of individuals with reproducibility results).</p

<i>CARD9</i> genetic variants affect abundances of selected chemokines and cytokines in active TB.

<p>Abundances (pg/ml) of selected soluble immune mediators for the three major haplotypes (rs4077515, rs10870077, rs10781499) analyzed. Each point corresponds to a single sample. Horizontal bars show the p-value in post-hoc Tukey Honest Significance Differences test, calculated after an initial ANOVA on log-transformed data.</p

Additional file 2 of Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Additional file 2. Supplementary tables. Supplementary Table 1 shows the results from the differential abundance analysis between patients with severe infections and healthy controls. Supplementary Table 2 shows the results from the differential abundance analysis between the two endotypes

Sputum microbiology and chest X-ray scoring.

<p>Sputum microbiology and chest X-ray scoring.</p

<i>CARD9</i> rs4077515, rs10870077, rs10781499 major haplotypes in active TB patients and healthy controls.

<p><i>CARD9</i> rs4077515, rs10870077, rs10781499 major haplotypes in active TB patients and healthy controls.</p

Additional file 1 of Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Additional file 1. Supplementary figure 1. Correlation plot of the 75 proteins included in the study in healthy controls and patients with severe infections. The correlation matrix was generated using the “psych” package in R and it was plotted using corrplot from the “rstatix” package. The colours represent the degree of pairwise correlation based on Spearman’s rank correlation coefficient. Positive correlations are depicted in red, while negative correlations are in blue. The size of the circles represents the magnitude of the correlation coefficient