10 research outputs found
General structure of the Markov model developed.
<p>It shows all clinically important events and transition paths from one state to another.</p
Cost per patient per year and confidence interval (95%), considering only patients in each phase.
<p>Notes: US = United States Dollar.</p
Average cost and confidence interval (95%) per patient per lifetime according to disease phase, by cost category.
<p>Notes: US = United States Dollar; Dx = Diagnosis; Tx = Treatment.</p
Average effectiveness and confidence interval (95%) per 100,000 blood donors and incremental cost-effectiveness ratio (ICER) according to health institution and coverage scenario.
<p>All costs in 2014 US$.</p
Cost-Effectiveness of Blood Donation Screening for <i>Trypanosoma cruzi</i> in Mexico
<div><p>An estimated 2 million inhabitants are infected with Chagas disease in Mexico, with highest prevalence coinciding with highest demographic density in the southern half of the country. After vector-borne transmission, <i>Trypanosoma cruzi</i> is principally transmitted to humans via blood transfusion. Despite initiation of serological screening of blood donations or donors for <i>T</i>. <i>cruzi</i> since 1990 in most Latin American countries, Mexico only finally included mandatory serological screening nationwide in official Norms in 2012. Most recent regulatory changes and segmented blood services in Mexico may affect compliance of mandatory screening guidelines. The objective of this study was to calculate the incremental cost-effectiveness ratio for total compliance of current guidelines from both Mexican primary healthcare and regular salaried worker health service institutions: the Secretary of Health and the Mexican Institute for Social Security. We developed a bi-modular model to analyze compliance using a decision tree for the most common screening algorithms for each health institution, and a Markov transition model for the natural history of illness and care. The incremental cost effectiveness ratio based on life-years gained is US 463 for the Social Security Institute. The results of the present study suggest that due to incomplete compliance of Mexico’s national legislation during 2013 and 2014, the MoH has failed to confirm 15,162 <i>T</i>. <i>cruzi</i> infections, has not prevented 2,347 avoidable infections, and has lost 333,483 life-years. Although there is a vast difference in <i>T</i>. <i>cruzi</i> prevalence between Bolivia and Mexico, Bolivia established mandatory blood screening for <i>T</i>.<i>cruzi</i> in 1996 and until 2002 detected and discarded 11,489 <i>T</i>. <i>cruzi</i> -infected blood units and prevented 2,879 potential infections with their transfusion blood screening program. In the first two years of Mexico’s mandated program, the two primary institutions failed to prevent due to incomplete compliance more potential infections than those gained from the first five years of Bolivia’s program. Full regulatory compliance should be clearly understood as mandatory for the sake of blood security, and its monitoring and analysis in Mexico should be part of the health authority’s responsibility.</p></div
General structure of the Markov model with all clinically important events and transition pathways, from one state to another.
<p>General structure of the Markov model with all clinically important events and transition pathways, from one state to another.</p
Acceptability curve for the willingness to pay per a year of life gained and per detected case for each alternative.
<p>Acceptability curve for the willingness to pay per a year of life gained and per detected case for each alternative.</p
Scenarios and decision tree model parameters, for each health institution.
<p>Scenarios and decision tree model parameters, for each health institution.</p
Decision trees used to simulate blood screening for MoH and IMSS scenarios.
<p>Decision trees used to simulate blood screening for MoH and IMSS scenarios.</p
Average total cost and confidence interval (95%) for 100,000 blood donations per cost category, health institution, and coverage scenario.
<p>Average total cost and confidence interval (95%) for 100,000 blood donations per cost category, health institution, and coverage scenario.</p